Cortexyme Announces Agreement to Acquire Novosteo Expanding pipeline with addition of targeted therapeutics to treat rare skeletal diseases, bone cancer and injury Strengthening leadership team with appointment of Novost

Cortexyme Announces Agreement to Acquire Novosteo

Expanding pipeline with addition of targeted therapeutics to treat rare skeletal diseases, bone cancer and injury

Strengthening leadership team with appointment of Novosteo executives Dr. Dirk Thye as CEO and

Dr. Karen Smith as CMO of combined company

Planning corporate name change to Quince Therapeutics to reflect broadening of therapeutic pipeline

SOUTH SAN FRANCISCO, Calif. May 10, 2022 Cortexyme, Inc. (Nasdaq: CRTX), a clinical-stage biopharmaceutical

company dedicated to improving the lives of patients diagnosed with degenerative diseases, today announced that it entered into an agreement under which the company plans to acquire Novosteo, a privately-held biotech company focused on targeted

therapeutics to treat rare skeletal diseases, bone cancer and injury. Upon completion of the transaction, Novosteo stockholders will own approximately 15.5% of the combined company. The transaction, which has been approved by the Boards of Directors

of both companies, is expected to close within the next 30 days.

David Lamond, chairman of Cortexyme s Board of Directors, said, The

acquisition of Novosteo adds a highly promising set of assets and meaningfully expands the breadth of our management team. We continue to review additional strategic actions that may opportunistically build upon our growing rare and degenerative

disease focus. On behalf of Cortexyme s Board, I would like to thank Chris Lowe for his leadership as interim CEO and guiding us through this acquisition.

Dr. Dirk Thye, chief executive officer of Novosteo, commented, We have assembled a highly experienced and impressive team to aggressively pursue

the company s next stage of growth. We intend to capitalize on the combined assets of Novosteo and Cortexyme by driving our therapeutic candidates through development, expanding our targeted drug discovery platform, and pursuing new business

development opportunities.

Pipeline Expansion with NOV004, a Precision Bone Growth Molecule for Rare Disease

The acquisition of Novosteo expands Cortexyme s drug development pipeline into rare disease indications with the addition of NOV004, a bone targeting

molecule designed to accelerate fracture repair, including in patients with osteogenesis imperfecta. Key highlights of the compound include:

Upon completion of the transaction, the company

will have capital resources of approximately $120 million in cash, cash equivalents and investments as of March 31, 2022, on a proforma basis with which to fund its combined operating requirements.

Leadership and Governance

Upon the close of the

acquisition, the company will appoint Novosteo executives Dr. Dirk Thye as chief executive officer, and Dr. Karen Smith as chief medical officer of Cortexyme, adding experienced leadership to support its next stage of growth. Dr. Dirk

Thye and Philip Low, PhD, a current director of Novosteo, will also join the company s Board of Directors upon close of the transaction.

also plans to operate under a new name Quince Therapeutics, Inc. and begin trading under the ticker symbol QNCX in the coming months. At that time, the company will present an overview of its pipeline development plans,

clinical activity updates, and anticipated milestones.

The acquisition of Novosteo reflects the strategic expansion of our pipeline, which remains

focused on bringing innovative therapeutics to diseases with high unmet clinical needs, said Chris Lowe, Cortexyme s interim chief executive officer. We are excited about the addition of Novosteo s targeted therapy platform and

extensive preclinical data to our expanding therapeutic pipeline. I believe the appointments of Dr. Dirk Thye as CEO and Dr. Karen Smith as CMO will bring exceptional expertise to lead the company.

Cooley LLP acted as legal advisor to Cortexyme

and Wilson Sonsini Goodrich & Rosati acted as legal advisor to Novosteo.

Cortexyme, Inc. (Nasdaq: CRTX) is a clinical stage biopharmaceutical company dedicated to improving the lives of patients diagnosed with rare and degenerative

diseases. The company s innovative pipeline includes a precision bone growth molecule and drug-targeting platform to treat rare skeletal diseases, bone cancer and injury, in addition to small molecule therapeutics targeting the infectious

pathogen P. gingivalis role in degenerative disease progression, including for indications such as periodontal disease, oral potentially malignant disorders, and Alzheimer s disease, among others. To learn more about Cortexyme,

visit www.cortexyme.com or follow @Cortexyme on Twitter.

Forward-Looking Statements

Statements in this news release contain forward-looking statements that are subject to substantial risks and uncertainties. Forward-looking

statements contained in this news release may be identified by the use of words such as believe, expect, intend, potential, will or other similar words. Examples of forward-looking statements

include, among others, the ability of the parties to consummate the proposed merger transaction, satisfaction of closing conditions precedent to the consummation of the proposed merger transaction, potential delays in consummating the merger and the

ability of Cortexyme to timely and successfully achieve the anticipated benefits of the merger transaction, cash sufficiency forecast, the strategic development path for atuzaginstat and NOV004; its business plans, internal and external development

of the pipeline, strategy, planned FDA submissions and clinical trials and timeline, prospects, and milestone expectations; the timing and success of the company s clinical trials and related data, including plans and the ability to initiate,

conduct and/or complete current and additional studies; the timing of announcements and updates relating to its clinical trials and related data; the potential therapeutic benefits, safety and efficacy of the combined company s product

candidate or library of compounds; and statements about its ability to obtain, and the timing relating to, further development of its clinical candidates and other programs or indications, regulatory submissions and interactions with regulators.

Forward-looking statements are based on Cortexyme s current expectations and are subject to inherent uncertainties, risks, and assumptions that are difficult to predict and could cause actual results to differ materially from what the company

expects. Further, certain forward-looking statements are based on assumptions as to future events that may not prove to be accurate. Factors that could cause actual results to differ include, but are not limited to, the risks and uncertainties

described in the section titled Risk Factors in Cortexyme s Annual Report on Form 10-K filed with the Securities and Exchange Commission (SEC) on March 1, 2022, and other reports as filed

with the SEC. Forward-looking statements contained in this news release are made as of this date, and Cortexyme undertakes no duty to update such information except as required under applicable law.

Vice President, Corporate

Communications & Investor Relations