Schönfeld, D., Matschiner, G., Chatwel,l L., Trentmann, S., Gille, H., Hülsmeyer, M., Brown, N., Kaye, P.M., Schlehuber, S., Hohlbaum, A.M., Skerra, A. (2009) An engineered lipocalin specific for CTLA-4 reveals a combining site with structural and conformational features similar to antibodies. PNAS 19;106(20):8198-203.
Monday, June 23, 2025 BiopharmaWatch Research 1 min read
Key Takeaway: The article presents a study on an engineered lipocalin specific for CTLA-4, highlighting its structural and conformational similarities to antibodies. The research was published in PNAS and contributes to understanding CTLA-4 interactions. However, the article lacks specific details or implications of the findings.
Price reaction · baseline $22.05 (2025-06-20 close) · hit pre-market · 2 other PVLA headline(s) in the window, move may be shared
day 0 close · peak
+2.2%
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Best trade, last catalyst
+106%
120-day peak, hindsight
Typical move
8.9%
average across 5 past catalysts
Cash runway
~58 mo
Minimal dilution risk
Lead asset
PTX-022
Phase 3 · Pachyonychia Congenita
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