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A Phase 2 Safety and Efficacy Study of PRT3789 in Combination With Pembrolizumab in Patients With Advanced or Metastatic Solid Tumors and a SMARCA4 Mutation

Key Takeaway: The article discusses a Phase 2 study evaluating the safety and efficacy of PRT3789 in combination with pembrolizumab for patients with advanced or metastatic solid tumors harboring a SMARCA4 mutation. This study aims to explore new treatment avenues for this specific group of cancer patients. The trial is led by a team of experienced oncologists and researchers.
Price reaction · baseline $0.8859 (2025-05-30 close) · 1 other PRLD headline(s) in the window, move may be shared
day 0 close · peak
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Market Sentiment Analysis

POSITIVE FACTORS

  • Study focuses on a novel combination therapy for advanced tumors.
  • Involves a targeted approach for patients with specific genetic mutations.
  • Potential to improve treatment outcomes for a challenging patient population.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Best trade, last catalyst
+217%
120-day peak, hindsight
Typical move
8.2%
average across 4 past catalysts
Cash runway
~29 mo
Minimal dilution risk
Lead asset
PRT1419
Phase 1 · Multiple Myeloma

Full Press Release Details

Timothy A. Yap, MD, PhD; Martin E. Gutierrez, MD; Wade T. Iams, MD; Victor Moreno, MD, PhD; Tatiana Hernández Guerrero, MD, PhD; Guzmán Alonso, MD; Carlos A. Gomez‑Roca, MD; Sophie Postel‑Vinay, MD, PhD; Fabian Acker, MD; Anna R. Minchom, MB BCh, FRCP, MD(res); Natasha B. Leighl, MD, MMSc, FRCPC, FASCO; William F. Novotny, MD; Chris Tankersley, MSc; Megan Henry, BSN, RN; Sunhee Ro, PhD; Michael J. Chisamore, PhD; John Bridgewater, MRCP, PhD, FRCP

Frequently Asked Questions

What is the focus of the Phase 2 study?

The study focuses on the safety and efficacy of PRT3789 combined with pembrolizumab.

Who are the patients targeted in this study?

Patients with advanced or metastatic solid tumors and a SMARCA4 mutation are targeted.

What is the significance of the SMARCA4 mutation?

The SMARCA4 mutation is linked to specific types of cancer, making targeted therapies crucial.

Who is leading the study?

The study is led by a team of experienced oncologists and researchers.

Last updated: May 31, 2025