Full Press Release Details
Kitov to Present Data on NT219
in Combination with Keytruda and Erbitux at AACR International Cancer Immunotherapy Conference
Treatment with NT219 in combination with Keytruda
or Erbitux converted non-responding tumors to responders
TEL AVIV, Israel, Sept. 26, 2018 (GLOBE NEWSWIRE) -- Kitov
Pharma (NASDAQ/TASE: KTOV), an innovative biopharmaceutical company, today announced that Hadas Reuveni, Ph.D., Chief Technology
Officer at Kitov's subsidiary, TyrNovo Ltd., will present pre-clinical data on NT219, an anti-tumor resistance drug
candidate, in a poster session at the Fourth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating
Science into Survival, to be held September 30 - October 3, 2018, in New York.
"We are pleased to have been chosen to present an abstract
at the upcoming AACR meeting. These very exciting data, which we had also presented at a cancer conference earlier this year,
hold great promise for mobilizing the patient's immune system against tumors," Dr. Reuveni commented. "In the
future, tumors in patients who have functional immune systems may respond to NT219 both by blocking feedback pathways, overcoming
drug resistance, and by removing the protective shield' from the tumor, allowing anti-tumor immune attack."
The poster demonstrates NT219's efficacy in synergy with immuno-oncology
therapies, which are widely used today, but to which unfortunately most patients still do not respond. In double autologous PDX
models, dosing with NT219 converted tumors that were resistant to pembrolizumab (Keytruda ) into responsive tumors. The models
also demonstrated the efficacy of NT219 in enhancing the immunotherapeutic potential of cetuximab (Erbitux ).
Abstract Title: NT219, A Novel Dual Inhibitor of STAT3 and IRS1/2, Converts Immuno-Oncology Resistant Tumors to Responders
Session Date: Tuesday, October 2, 2018
Session Time: 12.45 p.m. - 3.15 p.m. EDT
Session Location: Poster Session B, New York Marriott Marquis, Westside Ballroom
NT219 is a small molecule that presents a new concept in cancer
therapy by promoting the degradation and inhibiting the phosphorylation of two oncology-related checkpoints, Insulin Receptor
Substrates (IRS) 1/2 and signal transducer and activator of transcription 3 (STAT3), respectively. While targeted anti-cancer
drugs inhibit the "ON" signal, NT219 activates the "OFF" switch, extensively blocking major oncogenic pathways.
In pre-clinical trials, NT219, in combination with several approved cancer drugs, displayed potent anti-tumor effects and increased
survival in various cancers, including sarcoma, melanoma, pancreatic, lung, head & neck, prostate and colon cancers, by preventing
the tumors from developing drug resistance and reversing resistance after it had been acquired. NT219 is developed by TyrNovo
Ltd., a Kitov Pharma company. For more information on TyrNovo please visit http://www.tyrnovopharma.com.
Kitov Pharma (Kitov Pharma Ltd.; NASDAQ/TASE: KTOV) is an innovative
biopharmaceutical drug development company. Leveraging deep regulatory and clinical-trial expertise, Kitov's veteran
team of healthcare and business professionals maintains a proven track record in streamlined end-to-end drug development and approval.
Kitov's flagship combination drug, Consensi achieved the primary efficacy endpoints for its Phase III and Phase III/IV
clinical trials, and was approved by the FDA for patients suffering from osteoarthritis pain and hypertension. NT219, which is
developed by its majority-owned subsidiary, TyrNovo Ltd., is a novel patented small molecule designed to overcome cancer drug
resistance that is currently in pre-clinical development. By lowering development risk and cost through fast-track regulatory
approval of innovative therapeutic candidates, Kitov is committed to delivering rapid ROI and long-term potential to investors,
while making a meaningful impact on people's lives. For more information on Kitov, the content of which is not part of
this press release, please visit http://www.kitovpharma.com.
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to be significantly different from any future results, performance or achievements expressed or implied by the forward-looking
statements. Important factors that could cause or contribute to such differences include, among others, risks relating to: risks
and uncertainties associated with completing the proposed settlement of the two U.S. shareholder class-action lawsuits, the number
of plaintiffs who may opt-out of the proposed settlement, and whether any proposed settlement is appealed; the fact that drug
development and commercialization involves a lengthy and expensive process with uncertain outcomes; our ability to successfully
develop and commercialize our pharmaceutical products; the expense, length, progress and results of any clinical trials; the lack
of sufficient funding to finance the clinical trials; the impact of any changes in regulation and legislation that could affect
the pharmaceutical industry; the difficulty in receiving the regulatory approvals necessary in order to commercialize our products;
the difficulty of predicting actions of the U.S. Food and Drug Administration or any other applicable regulator of pharmaceutical
products; the regulatory environment and changes in the health policies and regimes in the countries in which we operate; the
uncertainty surrounding the actual market reception to our pharmaceutical products once cleared for marketing in a particular
market; the introduction of competing products; patents attained by competitors; dependence on the effectiveness of our patents
and other protections for innovative products; our ability to obtain, maintain and defend issued patents with protective claims;
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damages in any such action; and the exposure to litigation, including patent litigation, and/or regulatory actions; the continued
uncertainty surrounding an investigation by the Israel Securities Authority into our historical public disclosures and the potential
impact of such investigation on the trading of our securities or on our clinical, commercial and other business relationships;
or on receiving the regulatory approvals necessary in order to commercialize our products; the uncertainty of the impact of such
investigation and/or the proposed settlement of the two U.S. shareholder class-action lawsuits on the Israeli class action civil
litigation in connection with the investigation which is still continuing, and other factors that are discussed in our in our
Annual Report on Form 20-F for the year ended December 31, 2017 and in our other filings with the SEC, including our cautionary
discussion of risks and uncertainties under Risk Factors' in our Registration Statements, Prospectuses and Annual Reports. These
are factors that we believe could cause our actual results to differ materially from expected results. Other factors besides those
we have listed could also adversely affect us. Any forward-looking statement in this press release speaks only as of the date
which it is made. We disclaim any intention or obligation to publicly update or revise any forward-looking statement, or other
information contained herein, whether as a result of new information, future events or otherwise, except as required by applicable
law. You are advised, however, to consult any additional disclosures we make in our reports to the SEC, which are available on
the SEC's website, http://www.sec.gov
For further information, contact:
Chief Financial Officer of Kitov
+972-3-933-3121 ext. #105