Kitov Signs Marketing and Distribution Agreement for its Lead Product Consensi in the U.S. with Coeptis Pharmaceuticals - Kitov to receive $3.5M milestone payments and 40% - 60% of net profit on sales of Consensi - Coept

Signs Marketing and Distribution Agreement for its Lead Product Consensi in the U.S. with Coeptis Pharmaceuticals

Kitov to receive $3.5M milestone payments and 40% - 60% of net profit on sales of Consensi

Coeptis to cover all CMC, sales, and marketing expenses

AVIV, Israel, January 3, 2019- Kitov Pharma (NASDAQ/TASE: KTOV), an innovative

pharmaceutical company, today announced it has signed an exclusive marketing and distribution agreement with Coeptis

Pharmaceuticals for the U.S. market. Coeptis will commercialize Kitov's combination drug, Consensi , intended to

simultaneously treat osteoarthritis pain and hypertension.

agreement provides for total milestone payments from Coeptis to Kitov of $3.5 million, of which Kitov has already received the

initial milestone upon execution of the agreement, and additional milestone payments are due upon completion of an agreed Chemistry,

Manufacturing, Contol (CMC) plan and upon first commercial sales in the U.S. In addition, Kitov will be paid 40%-60% of Coeptis'

net profit on Consensi sales. The agreement is for a term of fifteen years and may be extended for additional two-year

terms and includes customary provisions, as well as certain residual rights and obligations of the parties following termination.

under patent protection in the U.S. until 2030, is expected to be launched during 2019, and will be the only NSAID whose labeling

indicates a reduction of blood pressure and consequent risk reduction of heart attack, stroke and death. For patients, Consensi

treats two conditions simultaneously, thereby increasing convenience (one pill instead of two) and may offer lower co-pays. The

therapy may contribute to improved patient compliance and improved patient health, thereby lowering overall health care costs.

agreement with Coeptis is Kitov's third licensing and distribution agreement as part of its worldwide commercialization

plans for Consensi . Kitov has previously signed licensing and distribution agreements for the drug in China and South Korea,

and Kitov is currently evaluating additional commercialization agreements in major markets worldwide.

commercialization structure for Consensi is one that we believe optimizes Kitov's near and long-term cash flows,

enabling us to continue to develop and deliver additional innovative pharmaceuticals, while maximizing ROI for our shareholders.

We are very pleased by the opportunity to work with Coeptis and its outstanding team of executives with strong track records in

the pharmaceutical industry and look forward to Consensi creating better patient compliance and improved treatment for

people living with osteoarthritis pain and hypertension," Kitov's CEO, Isaac Israel stated. "In the U.S., an

estimated 44% of adults have both hypertension and osteoarthritis. Currently, these patients are not well served. We believe that

successful commercialization of Consensi in the U.S. will be a transformational value-creating event for Kitov."

Mehalick, CEO of Coeptis, said, "Consensi will substantially improve treatment for patients living with two highly

prevalent chronic conditions, delivering improved clinical outcomes and enhanced economics for healthcare providers. We anticipate

launching Consensi in the second half of 2019 and expect to have it widely available to the millions of Americans who can

benefit from this combination treatment."

US Prescribing Information, including BOXED WARNING and Medication Guide is available at: www.consensi.com.

is a combination of amlodipine besylate, a calcium channel blocker, and celecoxib, a nonsteroidal anti-inflammatory drug (NSAID),

indicated for patients for whom treatment with amlodipine for hypertension and celecoxib for osteoarthritis are appropriate. Lowering

blood pressure reduces the risk of fatal and nonfatal CV events, primarily strokes and myocardial infarctions.

is only available in a celecoxib strength of 200 mg and is only to be taken once daily.

Safety Information (ISI) for Consensi

following ISI is based on the Highlights section of the U.S. Prescribing Information for Consensi . Please consult the full

Prescribing Information for all of the labelled safety information for Consensi .

anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular (CV) thrombotic events, including myocardial

infarction and stroke, which can be fatal. This risk may occur early in the treatment and may increase with duration of use.

contraindicated in the setting of coronary artery bypass graft (CABG) surgery.

cause an increased risk of serious gastrointestinal (GI) adverse events, including bleeding, ulceration and perforation of the

stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly

patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events.

is contraindicated in patients with a known hypersensitivity to amlodipine, celecoxib or any of its inactive ingredients.

is contraindicated in patients with a known history of asthma, urticaria or other allergic-type reactions after taking aspirin

or other NSAIDs and in the setting of CABG surgery.

is contraindicated in patients with known demonstrated allergic-type reactions to sulfonamides.

warnings and precautions related to Consensi include the following:

should be warned about the potential signs and symptoms of hepatotoxicity and hepatic failure. Physicians should discontinue

Consensi if abnormal liver tests persist or worsen, or if clinical signs and symptoms of liver disease develop.

taking some antihypertensive medications may have impaired response to these therapies when taking NSAIDs. Physicians should carefully

monitor blood pressure.

hypotension is possible, particularly in patients with severe aortic stenosis.

angina and acute myocardial infarction, particularly in patients with severe obstructive coronary artery disease, is possible.

should avoid use of Consensi in patients with severe heart failure.

should monitor renal function in patients with renal or hepatic impairment, heart failure, dehydration, or hypovolemia, and avoid

the use of Consensi in patients with advanced renal disease.

should seek emergency help if an anaphylactic reaction occurs.

is contraindicated in patients with aspirin-sensitive asthma. Monitor patients with preexisting asthma (without aspirin sensitivity).

should discontinue Consensi at the first appearance of skin rash or other signs of hypersensitivity.

such as Consensi can cause premature Closure of Fetal Ductus Arteriosus.

use in pregnant women starting at 30 weeks of gestation.

should monitor hemoglobin or hematocrit in patients with any signs or symptoms of anemia.

is not recommended in patients with moderate or severe hepatic impairment or severe renal insufficiency.

is not recommended in Poor Metabolizers of CYP2C9 Substrates.

report SUSPECTED ADVERSE REACTIONS, contact Kitov Pharma at 1-800-651-6606 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch

Coeptis Pharmaceuticals

Pharmaceuticals, Inc. is a privately held biopharmaceutical company engaged in the acquisition, development and commercialization

of branded and generic pharmaceutical products. The company owns an expansive portfolio of biotechnology assets encompassing a

wide array of treatments including advanced innovations for cellular therapies such as CAR-T and CAR-NK with a focus

on cancer, and various small molecule therapies for neurological based indications. Headquartered near Pittsburgh, PA, the

company holds a robust pipeline of products in various stages of development and commercialization. http://www.coeptispharma.com

(Information provided by Coeptis.)

Pharma (Kitov Pharma Ltd.; NASDAQ/TASE: KTOV) is an innovative pharmaceutical drug development company. Leveraging deep regulatory

and clinical-trial expertise, Kitov's veteran team of healthcare and business professionals maintains a proven track record in

streamlined end-to-end drug development and approval. Kitov's flagship combination drug, Consensi , intended to treat osteoarthritis

pain and hypertension simultaneously, was approved by the FDA for marketing in the U.S. In addition, Kitov's NT219, is a

novel patented small molecule designed to overcome cancer drug resistance that is currently in pre-clinical development. By lowering

development risk and cost through fast-track regulatory approval of novel late-stage therapeutics, Kitov plans to deliver rapid

ROI and long-term potential to investors, while making a meaningful impact on people's lives. For more information on Kitov, the

content of which is not part of this press release, please visit http://www.kitovpharma.com.

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comparable words or by the fact that these statements do not relate strictly to historical matters. You should not place undue

reliance on these forward-looking statements, which are not guarantees of future performance. Forward-looking statements reflect

our current views, expectations, beliefs or intentions with respect to future events, and are subject to a number of assumptions,

involve known and unknown risks, many of which are beyond our control, as well as uncertainties and other factors that may cause

our actual results, performance or achievements to be significantly different from any future results, performance or achievements

expressed or implied by the forward-looking statements. Important factors that could cause or contribute to such differences include,

among others, risks relating to: the fact that drug development and commercialization involves a lengthy and expensive process

with uncertain outcomes; our ability to successfully develop and commercialize our pharmaceutical products; the expense, length,

progress and results of any clinical trials; the lack of sufficient funding to finance the clinical trials; the impact of any

changes in regulation and legislation that could affect the pharmaceutical industry; the difficulty in receiving the regulatory

approvals necessary in order to commercialize our products; the difficulty of predicting actions of the U.S. Food and Drug Administration

or any other applicable regulator of pharmaceutical products; the regulatory environment and changes in the health policies and