Full Press Release Details
Boosts Ownership in TyrNovo and Oncology Platform Through Exchange of Shares for Stock
AVIV, Israel, October 6, 2017 /PRNewswire/ --
Pharmaceuticals Holdings Ltd. (NASDAQ: KTOV, TASE: KTOV), ("Kitov" or "the Company") an innovative biopharmaceutical
company, announced today the acquisition of an additional 27% stake in TyrNovo Ltd., a privately- held developer of novel small
molecules in the oncology therapeutic field, from unaffiliated minority shareholders. As announced on January 13, 2017, Kitov
had acquired a controlling interest, which is now approximately 65% of TyrNovo. After the closing of this transaction, Kitov will
hold approximately 92% of TyrNovo's issued and outstanding ordinary shares.
negotiations with a group of unaffiliated minority shareholders who collectively hold approximately 27%, of TyrNovo, the Company
has entered into an agreement to acquire their shares based on an agreed upon TyrNovo valuation of $7 million. In exchange for
these TyrNovo shares, Kitov will issue 13,169,689 new shares (equivalent to 658,484 American Depositary Shares or ADSs) of Kitov,
at an agreed upon price, in excess of prevailing market prices, of $2.50 per ADS.
early 2017, NT219 demonstrated impressive efficacy results including in combination with Keytruda , where it converted non-responding
tumors to responders and blocked tumor progression in an immuno-oncology preclinical model. We are pleased to have negotiated
the opportunity for Kitov to increase its stake in TyrNovo. We are committed to the development of NT219, which we believe is
a highly attractive asset for Kitov's shareholders in the growing field of oncology" stated Mr. Isaac Israel, Chief
Executive Officer. "We believe that expanding our ownership in TyrNovo provides a significant opportunity for further growth
of Kitov and added value to our shareholders."
on the pre-clinical results generated to date, we are receiving solid preliminary interest from potential strategic partners for
NT219, which presents a novel, first-in-class mechanism of action in the oncology field."
is a small molecule that presents a new concept in cancer therapy by promoting the degradation and the phosphorylation of two
oncology-related checkpoints, Insulin Receptor Substrates (IRS) 1 and signal transducer and activator of transcription 3 (STAT3),
respectively. While targeted anti-cancer drugs inhibit the "ON" signal, NT219 activates the "OFF" switch,
extensively blocking major oncogenic pathways. In pre-clinical trials, NT219, in combination with several approved cancer drugs,
displayed potent anti-tumor effects and increased survival in various cancers by preventing the tumors from developing -drug resistance
and reversing resistance after it has been acquired. In combination with various approved oncology drugs, NT219 demonstrated potent
anti-tumor effects and increased survival in various cancer models including sarcoma, melanoma, pancreatic, lung, ovarian, head
& neck, prostate and colon cancers, through the prevention of acquired resistance and regression of resistant tumors.
is developing NT219, a small molecule originally developed by Dr. Hadas Reuveni and Prof. Alexander Levitzki at the Hebrew University,
and exclusively licensed from Yissum, the Hebrew University Research Development Company. TyrNovo demonstrated the potential of
NT219 to overcome resistance to multiple anti-cancer drugs, by using the Patient-Derived Xenograft (PDX) models, in collaboration
with Prof. Izhak Haviv from the Bar-Ilan University and Prof. M. Stemmer from Clalit HMO.
Kitov Pharmaceuticals
Pharmaceuticals (NASDAQ: KTOV, TASE: KTOV) is an innovative biopharmaceutical drug development company. Leveraging deep regulatory
and clinical-trial expertise, Kitov's veteran team of healthcare professionals maintains a proven track record in streamlined
end-to-end drug development and approval. Kitov's flagship combination drug, KIT-302, intended to treat osteoarthritis pain and
hypertension simultaneously, achieved the primary efficacy endpoint for its Phase III clinical trial. Kitov's newest drug, NT219,
which is developed by its majority-owned subsidiary, TyrNovo Ltd., is a small molecule that presents a new concept in cancer therapy,
and in combination with various approved oncology drugs, demonstrated potent anti-tumor effects and increased survival in various
cancer models. By lowering development risk and cost through fast-track regulatory approval of novel therapeutics, Kitov plans
to deliver rapid ROI and long-term potential to investors, while making a meaningful impact on people's lives. For more information
on Kitov, the content of which is not part of this press release, please visit http://www.kitovpharma.com.
Statements and Kitov's Safe Harbor Statement
statements in this press release are forward-looking statements within the meaning of the safe harbor provisions of the Private
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comparable words or by the fact that these statements do not relate strictly to historical matters. You should not place undue
reliance on these forward-looking statements, which are not guarantees of future performance. Forward-looking statements reflect
our current views, expectations, beliefs or intentions with respect to future events, and are subject to a number of assumptions,
involve known and unknown risks, many of which are beyond our control, as well as uncertainties and other factors that may
cause our actual results, performance or achievements to be significantly different from any future results, performance or achievements
expressed or implied by the forward-looking statements. Important factors that could cause or contribute to such differences include,
among others, risks relating to: the fact that drug development and commercialization involves a lengthy and expensive process
with uncertain outcomes; our ability to successfully develop and commercialize our pharmaceutical products; the expense, length,
progress and results of any clinical trials; the lack of sufficient funding to finance the clinical trials; the impact of any
changes in regulation and legislation that could affect the pharmaceutical industry; the difficulty in receiving the regulatory
approvals necessary in order to commercialize our products; the difficulty of predicting actions of the U.S. Food and Drug Administration
or any other applicable regulator of pharmaceutical products; the regulatory environment and changes in the health policies and
regimes in the countries in which we operate; the uncertainty surrounding the actual market reception to our pharmaceutical products
once cleared for marketing in a particular market; the introduction of competing products; patents attained by competitors; dependence
on the effectiveness of our patents and other protections for innovative products; our ability to obtain, maintain and defend
issued patents with protective claims; the commencement of any patent interference or infringement action; our ability to prevail,
obtain a favorable decision or recover damages in any such action; and the exposure to litigation, including patent litigation,
and/or regulatory actions; the uncertainty surrounding an investigation by the Israel Securities Authority into our historical
public disclosures and the potential impact of such investigation on the trading of our securities or on our clinical, commercial
and other business relationships, or on receiving the regulatory approvals necessary in order to commercialize our products, and
other factors that are discussed in our in our Annual Report on Form 20-F for the year ended December 31, 2016 and in our other
filings with the SEC, including our cautionary discussion of risks and uncertainties under "Risk Factors" in our Registration
Statements and Annual Reports. These are factors that we believe could cause our actual results to differ materially from expected
results. Other factors besides those we have listed could also adversely affect us. Any forward-looking statement in this press
release speaks only as of the date which it is made. We disclaim any intention or obligation to publicly update or revise any
forward-looking statement, or other information contained herein, whether as a result of new information, future events or otherwise,
except as required by applicable law. You are advised, however, to consult any additional disclosures we make in our reports to
the SEC, which are available on the SEC's website, http://www.sec.gov.
Chief Financial Officer
+972-3-9333121 ext. #105
LifeSci Advisors, LLC