Insulet Reports Full Year 2022 Revenue Increase of 19% (22% constant currency 1 ) and Fourth Quarter 2022 Revenue Increase of 20% Year-Over-Year (24% constant currency) Represents 7th Consecutive Year of 20% or More Cons

Insulet Reports Full Year 2022 Revenue Increase of 19% (22% constant currency1)

and Fourth Quarter 2022 Revenue Increase of 20% Year-Over-Year (24% constant currency)

Represents 7th Consecutive Year of 20% or More Constant Currency Revenue Growth

ACTON, Mass. - February 23, 2023 - Insulet Corporation (NASDAQ PODD) (Insulet or the Company), the global leader in tubeless insulin pump technology with its Omnipod brand of products, today announced financial results for the three months and full year ended December 31, 2022.

Full Year Financial Highlights

Full year 2022 revenue of $1.3 billion, up 18.8%, or 22.5% in constant currency, compared to $1.1 billion in the prior year, exceeds the guidance range of 18% to 19% in constant currency

Total Omnipod revenue of $1.2 billion, an increase of 23.4%, or 27.4% in constant currency

U.S. Omnipod revenue of $884.8 million, an increase of 35.8%

International Omnipod revenue of $363.0 million, an increase of 0.9%, or 12.1% in constant currency

Drug Delivery revenue of $57.5 million, a decrease of 34.2%

Gross margin of 61.7%, down 670 basis points. Adjusted gross margin1 of 66.2% excludes a charge of $57.9 million associated with the voluntary medical device correction (MDC) notices issued to replace Omnipod DASH Personal Diabetes Managers (PDMs) and Omnipod 5 Automated Insulin Delivery system (Omnipod 5) Controllers

Operating income of $37.6 million, or 2.9% of revenue, compared to $126.0 million, or 11.5% of revenue, in the prior year. Adjusted operating income1 of $124.1 million, or 9.5% of revenue, excludes the $57.9 million charge noted above, as well as $25.2 million of certain legal costs and $3.4 million of CEO transition costs

Net income of $4.6 million, or $0.07 per diluted share, compared to net income of $16.8 million, or $0.24 per diluted share, in the prior year. Adjusted net income1 of $91.1 million, or $1.30 per diluted share excludes charges of $57.9 million, $25.2 million and $3.4 million noted above. Prior year adjusted net income of $59.2 million, or $0.86 per diluted share, excludes a loss on extinguishment of debt of $42.4 million

Adjusted EBITDA1 of $224.8 million, or 17.2% of revenue, compared to $215.9 million, or 19.6% of revenue, in the prior year

Fourth Quarter Financial Highlights

Fourth quarter 2022 revenue of $369.7 million, up 20.1%, or 23.7% in constant currency, compared to $307.7 million in the prior year, exceeds the guidance range of 11% to 14% in constant currency

Total Omnipod revenue of $366.4 million, an increase of 32.8%, or 36.8% in constant currency

U.S. Omnipod revenue of $276.2 million, an increase of 45.0%

International Omnipod revenue of $90.2 million, an increase of 5.7%, or 18.6% in constant currency

Drug Delivery revenue of $3.3 million, a decrease of 89.7%

Gross margin of 58.8%, down 1,050 basis points. Adjusted gross margin of 64.5% excludes a net charge of $21.1 million associated with the voluntary MDC notices noted above

1 See description of non-GAAP financial measures contained in this release.

Operating income of $23.5 million, or 6.4% of revenue, compared to operating income of $49.7 million, or 16.2% of revenue, in the prior year. Adjusted operating income of $42.5 million, or 11.5% of revenue, excludes the $21.1 million charge noted above, as well as income of $2.1 million related to an adjustment to a legal settlement charge

Net income of $17.0 million, or $0.24 per diluted share, compared to net income of $29.2 million, or $0.42 per diluted share, in the prior year. Adjusted net income of $36.0 million, or $0.52 per diluted share, excludes the $21.1 million charge and $2.1 million of income noted above. Prior year adjusted net income of $30.0 million, or $0.43 per diluted share, excludes a loss on extinguishment of debt of $0.8 million

Adjusted EBITDA of $71.4 million, or 19.3% of revenue, compared to $72.8 million, or 23.7% of revenue, in the prior year

Recent Strategic Highlights

Delivered seventh consecutive year of 20% or more constant currency revenue growth

Submitted to the FDA a 510(k) for a new basal-only Pod for individuals with type 2 diabetes

Achieved record quarterly U.S. and Total Omnipod new customer starts

Recently achieved milestones of 360,000 estimated active global customers using the Omnipod System, including over 100,000 U.S. customers using Omnipod 5

On track to begin Omnipod 5 international launch mid-year

More than doubled intellectual property portfolio over the last year through record patent filings and a recent strategic asset acquisition

Presented first release of real-world evidence for Omnipod 5 at the ATTD International Diabetes Congress for over 31,000 users demonstrating glycemic results similar to those observed in the pivotal trials and reinforcing the benefits of the customizable Target Glucose setting

Omnipod 5 feasibility study data for individuals with type 2 diabetes published in Diabetes Care2

Omnipod DASH real-world evidence on clinical outcomes in over 4,700 individuals with type 1 diabetes published in Diabetes Therapy3

Recognized by Newsweek as one of America's most responsible companies4

"2022 was another successful year for Insulet as we delivered strong revenue growth and advanced our strategic priorities," said Jim Hollingshead, President and Chief Executive Officer. "We entered 2023 with significant momentum and expect to further strengthen our foundation for long-term sustainable growth. We are excited about the commercial launch of Omnipod 5, which is a transformative technology offering users award-winning innovation and improved outcomes and quality of life. We are proud of all we have accomplished and the entire Insulet team is focused on building on our success and furthering our mission to improve the lives of people with diabetes."

Revenue Guidance (in constant currency)

For the year ending December 31, 2023, the Company expects revenue growth in the range of 14% to 19%. Revenue growth ranges by product line are

Total Omnipod of 17% to 22%

U.S. Omnipod of 21% to 26%

2 https pubmed.ncbi.nlm.nih.gov 36787903 .

3 https pubmed.ncbi.nlm.nih.gov 36763329 .

4 https www.newsweek.com rankings americas-most-responsible-companies-2023.

International Omnipod of 6% to 10%

Drug Delivery of (55)% to (45)%

For the quarter ending March 31, 2023, the Company expects revenue growth of 11% to 14%. Revenue growth ranges by product line are

Total Omnipod of 22% to 25%

U.S. Omnipod of 33% to 36%

International Omnipod of 4% to 7%

Drug Delivery of (100)% to (95)%

Gross Margin and Operating Margin Guidance

For the year ending December 31, 2023, the Company expects gross margin of 65% to 66%.

For the year ending December 31, 2023, the Company expects operating margin of high-single digits.

Insulet will host a conference call at 4 30 p.m. (Eastern Time) on February 23, 2023 to discuss the financial results and outlook. The link to the live call will be available on the Investor Relations section of the Company's website at investors.insulet.com, "Events and Presentations," and will be archived for future reference. The live call may also be accessed by dialing (888) 770-7129 for domestic callers or (929) 203-2109 for international callers, passcode 5904836.

About Insulet Corporation

Insulet Corporation (NASDAQ PODD), headquartered in Massachusetts, is an innovative medical device company dedicated to simplifying life for people with diabetes and other conditions through its Omnipod product platform. The Omnipod Insulin Management System provides a unique alternative to traditional insulin delivery methods. With its simple, wearable design, the disposable Pod provides up to three days of non-stop insulin delivery, without the need to see or handle a needle. Insulet's latest innovation, the Omnipod 5 Automated Insulin Delivery System, is a tubeless automated insulin delivery system, integrated with a continuous glucose monitor to manage blood sugar with no multiple daily injections, zero fingersticks, and is fully controlled by a compatible personal smartphone. Insulet also leverages the unique design of its Pod by tailoring its Omnipod technology platform for the delivery of non-insulin subcutaneous drugs across other therapeutic areas. For more information, please visit insulet.com and omnipod.com.

The Company uses the following non-GAAP financial measures

Constant currency revenue growth, which represents the change in revenue between current and prior year periods using the exchange rate in effect during the applicable prior year period. Insulet presents constant currency revenue growth because management believes it provides meaningful information regarding the Company's results on a consistent and comparable basis. Management uses this non-GAAP financial measure, in addition to financial measures in accordance with generally accepted accounting principles in the United States (GAAP), to evaluate the Company's

operating results. It is also one of the performance metrics that determines management incentive compensation.

Adjusted gross margin, adjusted gross margin as a percentage of revenue, adjusted operating income, adjusted operating income as a percentage of revenue, adjusted net income, and adjusted diluted earnings per share, all of which exclude the impact of certain significant transactions or events, such as legal settlements, medical device corrections and loss on extinguishment of debt, that affect the period-to-period comparability of our operating performance, as applicable.

Adjusted EBITDA, which represents net income (loss) plus net interest expense, income tax expense (benefit), depreciation and amortization, stock-based compensation expense and other significant transactions or events, such as legal settlements, medical device corrections and loss on extinguishment of debt, that affect the period-to-period comparability of our operating performance, as applicable, and adjusted EBITDA as a percentage of revenue.

Insulet presents the above non-GAAP financial measures because management uses them as supplemental measures in assessing the Company's operating performance, and the Company believes they are helpful to investors, and other interested parties as measures of comparative operating performance from period to period. They also are commonly used measures in determining business value and the Company uses them internally to report results.

These non-GAAP financial measures should be considered supplemental to, and not a substitute for, the Company's reported financial results prepared in accordance with GAAP. Furthermore, the Company's definition of these non-GAAP measures may differ from similarly titled measures used by others. Because non-GAAP financial measures exclude the effect of items that will increase or decrease the Company's reported results of operations, Insulet strongly encourages investors to review the Company's consolidated financial statements and publicly filed reports in their entirety.

Forward-Looking Statement

This press release contains forward-looking statements regarding, among other things, future operating and financial performance, product success and efficacy, the outcome of studies and trials and the approval of products by regulatory bodies. These forward-looking statements are based on management's current beliefs, assumptions and estimates and are not intended to be a guarantee of future events or performance. If management's underlying assumptions turn out to be incorrect, or if certain risks or uncertainties materialize, actual results could vary materially from the expectations and projections expressed or implied by the forward-looking statements.

Risks and uncertainties include, but are not limited to adverse changes in general economic conditions as well as risks associated with public health crises and pandemics, such as the COVID-19 global pandemic, government actions and restrictive measures implemented in response, supply chain disruptions, delays in clinical trials, and other impacts to the business, our customers, suppliers, and employees dependence on a principal product platform ability to maintain and grow our customer base ability to scale the business to support revenue growth maintenance of an effective sales force and expansion of distribution network ability to secure and retain adequate coverage or reimbursement from third-party payors impact of healthcare reform laws impact of competitive products, technological change and product innovation ability to design, develop, manufacture and commercialize future products inability to maintain or enter into new license or other agreements with respect to continuous glucose monitors, data management systems or other rights necessary to sell our current product and or commercialize future products

challenges to the future development of our non-insulin drug delivery product line international business risks, including regulatory, commercial and logistics risks supply problems or price fluctuations with sole source or third-party suppliers on which we are dependent failure to retain key suppliers ability to protect our intellectual property and other proprietary rights and potential conflicts with the intellectual property of third parties extensive government regulation applicable to medical devices as well as complex and evolving privacy and data protection laws adverse regulatory or legal actions relating to the Omnipod System or future products failure of our contract manufacturer or component suppliers to comply with the U.S. Food and Drug Administration's quality system regulations potential adverse impacts resulting from a recall, or discovery of serious safety issues, or product liability lawsuits relating to off-label use the potential violation of anti-bribery anti-corruption laws breaches or failures of our product or information technology systems, including by cyberattack unfavorable results of clinical studies, including issues with third parties conducting any studies, or future publication of articles or announcement of positions by diabetes associations or other organizations that are unfavorable the concentration of manufacturing operations and storage of inventory in a limited number of locations loss of employees or inability to identify and recruit new employees ability to generate sufficient cash to service our indebtedness or raise additional funds on acceptable terms or at all the volatility of the trading price of our common stock risks related to the conversion of outstanding Convertible Senior Notes and potential limitations on our ability to use net operating loss carryforwards.

For a further list and description of these and other important risks and uncertainties that may affect our future operations, see Part I, Item 1A - Risk Factors in our most recent Annual Report on Form 10-K filed with the Securities and Exchange Commission, which we may update in Part II, Item 1A - Risk Factors in Quarterly Reports on Form 10-Q we have filed or will file hereafter. Any forward-looking statement made in this release speaks only as of the date of this release. Insulet does not undertake to update any forward-looking statement, other than as required by law.

2023 Insulet Corporation. Omnipod, Omnipod DASH and Omnipod 5 are registered trademarks of Insulet Corporation.

Vice President, Investor Relations

Angela Geryak Wiczek

Senior Director, Corporate Communications

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (UNAUDITED)

CONDENSED CONSOLIDATED BALANCE SHEETS (UNAUDITED)

NON-GAAP RECONCILIATIONS (UNAUDITED)

CONSTANT CURRENCY REVENUE GROWTH

NON-GAAP RECONCILIATIONS CONTINUED (UNAUDITED)

ADJUSTED GROSS MARGIN, OPERATING MARGIN, NET INCOME AND DILUTED EPS

REVENUE GUIDANCE RECONCILIATIONS (UNAUDITED)