Full Press Release Details
Opening and Strategic Overview Patrick NJ Schnegelsberg, CEO
Technology and Product Pipeline Matt Schuster, COO
Operational Strategy and Manufacturing Initiatives Matt Schuster, COO
Financial Overview Bernard Skaggs, CFO
Experience with the SynCardia TAH Amy Fiedler, MD Associate Professor of Surgery, Surgical Director of Heart Transplantation and Mechanical Circulatory Support, UCSF
Amy G. Fiedler, MD Associate Professor of Cardiac Surgery Surgical Director of Heart Transplantation and Mechanical Circulatory Support Total Artificial Heart A Cardiac Surgeons Perspective
35 Objectives Overview of our heart failure program at UCSF Describe our path to TAH and subsequent growth Review patient selection (key for success) Surgical technique Discuss our institutional outcomes to date Next steps for future growth and collaboration
36 AHFCCC - UCSF Advanced Heart Failure Comprehensive Care Center Top 8 heart transplant program in the US Largest VA ECMO program in the West 5 th largest LVAD HM3 center in the West
37 Our journey to TAH It takes a team Busy LVAD center Busy transplant center Fantastic coordinators + nurses Innovative leadership Surgeons with experience
38 Patient Selection Biventricular failure Age Status of end organs Multi - disciplinary evaluation Potential transplant candidacy in the future Rehabilitation potential
39 Patient Selection
40 Surgical Technique - Tips and Tricks Minimize any unnecessary dissection Sew the aorta and PA grafts on first Double layer 3 - 0 MH prolene on sewing cuffs Loops around SVC, IVC, aorta Goretex + close pericardium Delayed chest closure until exquisitely dry
41 Institutional Outcomes to Date Program began November 2024 5 TAH implants - 2 with successful OHT - 1 awaiting discharge - 2 expired
44 Next Steps for Growth / Collaboration SynCardia x UCSF UCSF to become a destination center for TAH Collaborative outreach events across the country promoting TAH x UCSF Partnering to publish outcomes, best practices, and practice changing techniques Discuss possibility of cross - collaboration to identify RV failure after LVAD and selecting those patients for TAH support
Patient Perspective Former SynCardia Patient
Future of Mechanical Circulatory Support Innovation Zain Khalpey, MD, PhD, FACS Chief Medical Artificial Intelligence Officer, Network Director for the Artificial Heart Program, HonorHealth, Phoenix
Closing Remarks with Q&A Patrick NJ Schnegelsberg, CEO