Full Press Release Details
PharmaCyte Biotech Issues Follow-Up Response
to Iroquois Capital's Second Letter on June 9 and Reiterates Commitment to Increasing Shareholder Value
LAS VEGAS, NV, June 15, 2022, PharmaCyte Biotech, Inc. (NASDAQ: PMCB)
(PharmaCyte), a biotechnology company focused on developing cellular therapies for cancer, diabetes and malignant ascites using its signature
live-cell encapsulation technology, Cell-in-a-Box , today issued the following statement in response to the second
letter issued by Iroquois Capital (Iroquois) on June 9, 2022:
We Take Issue with Iroquois' Unfounded Statements
On June 7, 2022, we issued a detailed letter to our shareholders outlining
our growth strategy and additional steps being taken to enhance long-term shareholder value, and we have received positive responses from
many shareholders. We have always encouraged feedback from shareholders, which is how our relationship with Iroquois began. However, we
find Iroquois' decision to continue to publicly issue unfounded statements that misrepresent our actions troubling and potentially
detrimental to long-term shareholder value.
Board and Management Refuse to be Distracted
We remain focused on what matters most - the development of our
cellulose-based live-cell encapsulation technology, which we believe holds tremendous promise for treating various diseases that have
often been addressed unsuccessfully, including cancer, diabetes and malignant ascites. As we have stated, we are making substantial
progress toward a Phase 2b clinical trial for a promising therapy for pancreatic cancer. We have accelerated preparations for the
clinical trial for this therapy so that we will be ready to enroll our first patient and begin the clinical trial almost immediately upon
the FDA lifting the clinical hold. We believe this accelerated approach will save approximately six months or more of time from what was
originally estimated. We are confident that our previously stated strategy will deliver exponentially higher shareholder value over
time and that Iroquois' persistence in raising issues that are already being addressed is an unnecessary distraction that does not
benefit shareholders.
Our Diverse Board Brings Extraordinary Experience in Our Target
Markets and We Are Actively Looking to Add Additional Capital Markets Experience
We strongly disagree with Iroquois' mischaracterization of our
Board as "dysfunctional." To the contrary, our Board brings considerable relevant experience and has played a vital role in
helping to advance our operating strategy - working with management through the complexities associated with getting the FDA hold
lifted and preparing for the Phase 2b trial.
It has always been important, and remains critical, for our Board to
have a strong background and focus on the science that drives our leading product candidates. If the science fails, nothing else matters.
Most recently, we further strengthened the Board with our announcement in a press release dated April 5, 2022, of the addition of Dr.
Matthias L hr, a person whose life's work and passion are specifically in the areas of the therapies PharmaCyte is developing.
Our Board, which Iroquois calls "dysfunctional," oversaw
our successful uplisting to Nasdaq and two capital raises totaling almost $90 million. This large cash position has proven to be a critical
strategic advantage for a small cap research and development stage company like PharmaCyte, enabling us to remain focused on our longer-term
growth strategy in a very difficult financial environment. However, it is not lost on us that given the growth opportunities in front
of our company, that deeper and broader capital markets experience is now needed on our Board. We are in the process of reviewing and
thoroughly vetting candidates with that experience. What Iroquois failed to mention in its two letters is that we have, on multiple
occasions, offered to review candidates that Iroquois wishes to put forward. Iroquois has yet to recommend a single candidate.
New Executive Compensation Agreements Better Align Management with
Iroquois also insinuated that we are somehow being less than forthright
and engaging in poor corporate governance by not setting forth our entire executive compensation program in a Form 8-K. Consistent with
common practice, we will provide additional details as part of our Form 10-K for our fiscal year end which we plan to file in mid-July.
The new long-term Executive Compensation Agreements better align the compensation of our executive management with corporate performance
and include cash and equity bonuses tied to achievement of specified corporate goals. These goals are consistent with the strategy that
we have laid out and continue to reinforce with investors, including Iroquois.
Well before Iroquois began publicly expressing its grievances, our
Board and management were planning many of the initiatives for which Iroquois is conveniently trying to take credit. We share in the frustration
with the current share price, and we are actively taking steps to address this as specified in our June 7 letter to our shareholders.
The most important thing we can do is continue to dedicate the majority of our time and resources to advancing through the clinic our
ground-breaking technology. We have heard and given thoughtful consideration and response to the opinions Iroquois has put forward. However,
we will not let one shareholder distract us from our ultimate mission - the continued development of and successful clinical trials
for our groundbreaking therapies - to the detriment of all other shareholders.
Thank you for your continued support. We look forward to communicating
with you in the coming days on our progress in developing our leading product candidates.
About PharmaCyte Biotech
PharmaCyte Biotech, Inc. is a biotechnology company developing cellular
therapies for cancer, diabetes and malignant ascites based upon a proprietary cellulose-based live-cell encapsulation technology known
as "Cell-in-a-Box ." This technology is being used as a platform upon which therapies for several types of
cancer, diabetes and malignant ascites are being developed.
PharmaCyte's therapy for cancer involves encapsulating genetically
engineered human cells that convert an inactive chemotherapy drug into its active or "cancer-killing" form. For pancreatic
cancer, these encapsulated cells are implanted in the blood supply to the patient's tumor as close as possible to the site of the
tumor. Once implanted, a chemotherapy drug that is normally activated in the liver (ifosfamide) is given intravenously at one-third the
normal dose. The ifosfamide is carried by the circulatory system to where the encapsulated cells have been implanted. When the ifosfamide
flows through pores in the capsules, the live cells inside act as a "bio-artificial liver" and activate the chemotherapy drug
at the site of the cancer. This "targeted chemotherapy" has proven effective and safe to use in past clinical trials and we
believe results in little to no treatment related side effects.
PharmaCyte's candidate therapy for Type 1 diabetes and insulin-dependent
Type 2 diabetes involves encapsulating a human cell line that has been genetically engineered to produce and release insulin in response
to the levels of blood sugar in the human body. The encapsulation of the cell line will be done using the Cell-in-a-Box
technology. Once the encapsulated cells are implanted in a diabetic patient, we anticipate that they will function as a "bio-artificial
pancreas" for purposes of insulin production.
PharmaCyte's therapy for malignant ascites involves using the
same encapsulated cells PharmaCyte employs for pancreatic cancer but placing the encapsulated cells in the peritoneal cavity of a patient
and administering ifosfamide intravenously.
This press release may contain forward-looking statements within the
meaning of the Private Securities Litigation Reform Act of 1995 that express the current beliefs and expectations of PharmaCyte's
management and Board of Directors. Any statements contained in this press release which do not describe historical facts are forward-looking
statements subject to risks and uncertainties that could cause actual results, performance and achievements to differ materially from
those discussed in such forward-looking statements. Factors that could affect our actual results include our ability to satisfactorily
address the issues raised by the FDA in order to have the clinical hold on our IND removed, as well as such other factors that are included
in the periodic reports on Form 10-K and Form 10-Q that we file with the U.S. Securities and Exchange Commission. These forward-looking
statements are made only as of the date hereof, and we undertake no obligation to update or revise the forward-looking statements, except
as otherwise required by law, whether as a result of new information, future events or otherwise.
More information about PharmaCyte Biotech can be found at https://www.PharmaCyte.com. Information
may also be obtained by contacting PharmaCyte's Investor Relations Department.
PharmaCyte Biotech, Inc.
Telephone: 917.595.2856
Attn: Dr. Gerald W. Crabtree