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Pharvaris Announces Data Highlighting Deucrictibant for the Treatment of HAE to be Presented at the 2024 HAEi Global Leadership Workshop

Key Takeaway: Pharvaris has announced the acceptance of six abstracts for presentation at the 2024 HAEi Global Leadership Workshop in Copenhagen. These abstracts will highlight the safety and efficacy of deucrictibant, a bradykinin B2 receptor antagonist aimed at preventing and treating hereditary angioedema (HAE) attacks. The sessions will feature both oral and poster presentations, scheduled for October 4-5, 2024. In addition to showcasing clinical data, Pharvaris plans to donate to the Marcus Maurer Fellowship Program in memory of a key figure in the field.
Price reaction · baseline $18.32 (2024-10-02 close) · hit after-hours · clean, no other PHVS news in the window
day 0 close · peak
-2.3%

Market Sentiment Analysis

POSITIVE FACTORS

  • Acceptance of six abstracts highlighting the safety and efficacy of deucrictibant.
  • Promising results from trials support the development of deucrictibant for HAE.
  • Pharvaris plans to initiate pivotal Phase 3 studies, indicating progression in research.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Best trade, last catalyst
+50%
120-day peak, hindsight
Typical move
8.8%
average across 6 past catalysts
Lead asset
Deucrictibant
Phase 3 · Hereditary Angioedema (HAE)

Full Press Release Details

ZUG, Switzerland, Oct. 03, 2024 (GLOBE NEWSWIRE) -- Pharvaris (Nasdaq: PHVS), a late-stage biopharmaceutical company developing novel, oral bradykinin B2 receptor antagonists to prevent and treat hereditary angioedema (HAE) attacks, today announced the acceptance of six abstracts, two for oral presentation and four for poster presentation, at the 2024 Global Angioedema Forum – HAEi Global Leadership Workshop, taking place in Copenhagen, Denmark, from Oct. 4-5, 2024. Details are as follows:
Title: Long-Term Safety and Efficacy of Oral Deucrictibant, a Bradykinin B2 Receptor Antagonist, for Prophylaxis in Hereditary Angioedema: Results of the CHAPTER-1 Open-Label Extension Study
Presenter: Marc A. Reidel, M.D., M.S.
Format: Oral and Poster
Date, time: Oral: Saturday, Oct. 5, Session 5, 9:59 CEST (3:59 a.m. EDT) | Poster: Friday, Oct. 4, 18:00-18:30 CEST (12:00-12:30 p.m. EDT), Poster Walk 1
Title: Long-Term Efficacy and Safety of Oral Deucrictibant, a Bradykinin B2 Receptor Antagonist, in Treatment of Hereditary Angioedema Attacks: Results of the RAPIDe-2 Extension Study
Presenter: Anna Valerieva, M.D., Ph.D.
Format: Oral and Poster
Date, time: Oral: Saturday, Oct. 5, Session 5, 10:08 CEST (4:08 a.m. EDT) | Friday, Oct. 4, 18:30-19:00 CEST (12:30-1:00 p.m. EDT), Poster Walk 4
Title: Efficacy and Safety of Oral Deucrictibant, a Bradykinin B2 Receptor Antagonist, in Prophylaxis of Hereditary Angioedema Attacks: Results of CHAPTER-1 Phase 2 Trial
Presenter: Emel Aygören-Pursun, M.D.
Date, time: Friday, Oct. 4, 18:00-18:30 CEST (12:00-12:30 p.m. EDT), Poster Walk 3
Title: Prophylactic Treatment With Oral Deucrictibant Improves Health-Related Quality of Life of Patients with Hereditary Angioedema
Presenter: Andrea Zanichelli, M.D., Ph.D.
Date, time: Friday, Oct. 4, 18:30-19:00 CEST (12:30-1:00 p.m. EDT), Poster Walk 2
Title: Propensity Score-Matched Comparison of Outcomes for Deucrictibant vs. Standard of Care in People Living with Hereditary Angioedema
Presenter: Danny M. Cohn, M.D., Ph.D.
Date, time: Friday, Oct. 4, 18:30-19:00 CEST (12:30-1:00 p.m. EDT), Poster Walk 2
Title: Design of RAPIDe-3 Phase 3 Trial: Efficacy and Safety of the Oral Bradykinin B2 Receptor Antagonist Deucrictibant Immediate-Release Capsule in Treatment of Hereditary Angioedema Attacks
Presenter: Phillip H. Li, MBBS, FRCP
Date, time: Friday, Oct. 4, 18:00-19:00 CEST (12:00-1:00 p.m. EDT), Poster Walk 1
The presentation slides and posters will be available on the Investors section of the Pharvaris website at: https://ir.pharvaris.com/news-events/events-presentations.
In memory of Prof. Marcus Maurer, Professor of Dermatology and Allergy, Executive Director of the Institute of Allergology at the Charité – Universitätsmedizin Berlin, and Co-Director of Allergology and Immunology at the Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Pharvaris will make a donation to the Marcus Maurer Fellowship Program through GA2LEN, the Global Allergy and Asthma Excellence Network.
Pharvaris is a late-stage biopharmaceutical company developing novel, oral bradykinin B2 receptor antagonists to prevent and treat HAE attacks. By directly pursuing this clinically proven therapeutic target with novel small molecules, the Pharvaris team aspires to offer people with all types of bradykinin-mediated angioedema effective, well-tolerated, and easy-to-administer alternatives to treat attacks, both prophylactically and on-demand. With positive data in both Phase 2 prophylaxis and on-demand studies in HAE, Pharvaris is encouraged to further develop deucrictibant. Pharvaris is currently enrolling a pivotal Phase 3 study for the on-demand treatment of HAE attacks and plans to initiate a pivotal Phase 3 study of deucrictibant for the prevention of HAE attacks in the coming months. For more information, visit https://pharvaris.com/.

Frequently Asked Questions

What is Pharvaris developing for hereditary angioedema?

Pharvaris is developing novel oral bradykinin B2 receptor antagonists to prevent and treat HAE attacks.

Where will Pharvaris present its research?

Pharvaris will present research at the 2024 Global Angioedema Forum in Copenhagen.

Who is presenting on long-term efficacy of Deucrictibant?

Marc A. Reidel, M.D., M.S., will present on the long-term efficacy of Deucrictibant.

When is the RAPIDe-2 Extension Study presentation?

The RAPIDe-2 Extension Study will be presented on Saturday, Oct. 5.

What is Pharvaris's goal with Deucrictibant?

Pharvaris aims to provide effective alternatives for treating bradykinin-mediated angioedema.

Last updated: Oct 3, 2024