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Phio Pharmaceuticals to Present at the H.C. Wainwright 27 th Annual Global Investment Conference Clinical trial advances to anticipated final cohort for INSTASYL siRNA lead product candidate PH-762 5th cohort patients no

Key Takeaway: Phio Pharmaceuticals is progressing with its Phase 1b clinical trial for the siRNA product candidate PH-762, aimed at treating skin cancers. The company will present its findings at the H.C. Wainwright 27th Annual Global Investment Conference scheduled for September 8-10, 2025. CEO Robert Bitterman plans to discuss the development strategy for PH-762 as the trial approaches its final cohort. The treatment could potentially offer a non-surgical option for skin cancer patients. Forward-looking statements about the product's success and funding challenges highlight inherent risks in the ongoing clinical development.
Price reaction · baseline $2.12 (2025-09-02 close) · hit after-hours · 1 other PHIO headline(s) in the window, move may be shared
day 0 close
-1.9%

Market Sentiment Analysis

POSITIVE FACTORS

  • Advances to the final cohort in the PH-762 clinical trial.
  • PH-762 is a potential non-surgical treatment for several skin cancers.
  • Company to present at a major investment conference, indicating interest and confidence.

CONCERNS & RISKS

  • Risks associated with the uncertainty of clinical trial outcomes.
  • Dependence on future financing and market conditions for development.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Cash runway
~9 mo
Medium dilution risk
Lead asset
DP CD8 TIL
Phase 1 · HNSCC

Full Press Release Details

Phio Pharmaceuticals to Present at the H.C.
27th Annual Global Investment Conference
Clinical trial advances to anticipated final cohort for INSTASYL
siRNA lead product candidate PH-762
5th cohort patients now being treated in
on-going clinical study
KING OF PRUSSIA, PA-(Newsfile Corp.- September 3, 2025) - Phio
Pharmaceuticals Corp. (NASDAQ: PHIO) is a clinical-stage biopharmaceutical company developing therapeutics using its proprietary INTASYL
siRNA gene silencing technology to eliminate cancer. Phio today announced that Phio Pharmaceuticals is a presenting company at the H.C.
Wainwright 27th Annual Global Investment Conference to be held September 8 - 10, 2025.
Mr. Robert Bitterman, President and CEO of Phio Pharmaceuticals will
deliver an update on its on-going Phase 1b clinical trial for skin cancer. He will also be discussing strategy and anticipated next steps
in the PH-762 development program upon completion of the treatment phase of the study.
Presentation Details: September 10, 2025 at 1:30-2 PM EST
Location: 27th Annual H.C. Wainwright Global Investment Conference, Lotte New York Plaza Hotel, New York City, NY
Bitterman will also be available for one-on-one investor meetings throughout the conference September 8 - 10, 2025. Investors interested
in scheduling a meeting with the Phio Pharmaceuticals management team should contact their H.C. Wainwright representative or email meetings@hcwco.com.
About Phio Pharmaceuticals Corp.
Phio Pharmaceuticals Corp. (NASDAQ: PHIO) is a clinical-stage siRNA
biopharmaceutical company advancing its INTASYL gene silencing technology focused on immuno-oncology therapeutics. Phio's
INTASYL compounds are designed to enhance the body's immune cells to more effectively kill cancer cells. Phio's lead clinical
program is an INTASYL compound, PH-762, that silences the PD-1 gene implicated in various forms of skin cancer. The on-going Phase 1b
trial (NCT# 06014086) is evaluating PH-762 for the treatment of cutaneous squamous cell carcinoma, melanoma, and Merkel cell carcinoma.
PH-762 is a potential non-surgical treatment for skin cancers.
For additional information, visit the Company's website, www.phiopharma.com.
Forward Looking Statements
This press release contains forward-looking statements within the
meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by words such as "intends,"
"believes," "anticipates," "indicates," "plans," "expects," "suggests," "may,"
"would," "should," "potential," "designed to," "will," "ongoing," "estimate,"
"forecast," "target," "predict," "could" and similar references, although not all forward-looking
statements contain these words. Examples of forward-looking statements contained in this press release include, among others, the possibility
that our INTASYL siRNA gene silencing technology will make the body's immune cells more effective in killing cancer cells,
the potential for PH-762 to present a viable non-surgical alternative for skin cancer, expectations regarding timing of enrollment, the
expectations that we have sufficient capital to complete the treatment phase of our ongoing Phase 1b clinical trial, and statements regarding
our clinical strategy, development plans and timelines and other future events.
These statements are based only on our current beliefs, expectations
and assumptions and are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict and many of
which are outside of our control. Our actual results may differ materially from those indicated in the forward-looking statements
as a result of a number of important factors, including, but not limited to, results from our preclinical and clinical activities, our
ability to execute on business strategies, the timing or likelihood of regulatory filings and approvals, our ability to manufacture and
supply our product candidates for clinical activities, and for commercial use if approved, the scope of protection we are able to establish
and maintain for intellectual property rights covering our technology platform, our ability to obtain future financing, market and other
conditions and those identified in our Annual Report on Form 10-K and subsequent Quarterly Reports on Form 10-Q under the caption "Risk
Factors" and in other filings the Company periodically makes with the SEC. Readers are urged to review these risk factors and to
not act in reliance on any forward-looking statements, as actual results may differ from those contemplated by our forward-looking statements.
Phio does not undertake to update forward-looking statements to reflect a change in its views, events or circumstances that occur after
the date of this release, except as required by law.
Phio Pharmaceuticals Corp.

Frequently Asked Questions

What event will Phio Pharmaceuticals present at?

Phio Pharmaceuticals will present at the H.C. Wainwright 27th Annual Global Investment Conference.

What is Phio's lead product candidate?

Phio's lead product candidate is PH-762, designed for treating skin cancer.

When will the presentation take place?

The presentation is scheduled for September 10, 2025, from 1:30-2 PM EST.

What type of trial is PH-762 undergoing?

PH-762 is currently in an ongoing Phase 1b clinical trial for skin cancer.

How can investors schedule meetings with Phio?

Investors can contact H.C. Wainwright representatives or email meetings@hcwco.com.

Last updated: Sep 3, 2025