Precigen Company Update Helen Sabzevari, PhD President, Precigen 7 January 2019 Forward-looking statements Precigen, Inc. is a subsidiary of Intrexon Corporation (Nasdaq: XON). Some of the statements made in this present

Precigen Company Update Helen Sabzevari, PhD President, Precigen 7 January 2019

Forward-looking statements Precigen, Inc. is a subsidiary of Intrexon Corporation (Nasdaq: XON). Some of the

statements made in this presentation are forward-looking statements that involve a number of risks and uncertainties and are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. These forward-looking

statements are based upon Intrexon s and Precigen s current expectations and projections about future events and generally relate to plans, objectives and expectations for the development of Precigen s business, including the timing

and progress of preclinical and clinical trials and discovery programs and Precigen s planned manufacturing facility. Although management believes that the plans and objectives reflected in or suggested by these forward-looking statements are

reasonable, all forward-looking statements involve risks and uncertainties and actual future results may be materially different from the plans, objectives and expectations expressed in this presentation. These risks and uncertainties include, but

are not limited to, (i) Precigen s strategy and overall approach to its business model, including its ability to successfully enter into optimal strategic relationships with its subsidiaries and operating companies that Intrexon may form in the

future; (ii) the ability to successfully enter new markets or develop additional products, whether with its collaborators or independently; (iii) actual or anticipated variations in operating results; (iv) actual or anticipated fluctuations in

competitors or collaborators operating results or changes in their respective growth rates; (v) cash position; (vi) market conditions in Intrexon s and Precigen s industry; (vii) the volatility of Intrexon s stock price;

(viii) the ability, and the ability of collaborators, to protect intellectual property and other proprietary rights and technologies; (ix) the ability, and the ability of collaborators, to adapt to changes in laws or regulations and policies; (x)

the outcomes of pending or future litigation; (xi) the rate and degree of market acceptance of any products developed; (xii) the ability to retain and recruit key personnel; (xiii) expectations related to the use of proceeds from financing efforts;

and (xiv) estimates regarding expenses, future revenue, capital requirements and needs for additional financing. For a discussion of other risks and uncertainties, and other important factors, any of which could cause actual results to differ from

those contained in the forward-looking statements, see the section entitled Risk Factors in Intrexon s Annual Report on Form 10-K, as well as discussions of potential risks, uncertainties, and other important factors in

Intrexon s subsequent filings with the Securities and Exchange Commission. All information in this presentation is as of the date its cover page, and Intrexon undertakes no duty to update this information unless required by law. 2019

Today s agenda o Company overview o Technology platforms o Therapeutic platform: UltraCAR-TTM o

Preclinical and clinical portfolio o Therapeutic areas o Immuno-oncology o Infectious diseases o Autoimmune disorders o Summary o Q&A 3

Company overview o Company highlights o Precigen s evolution o State-of-the-art infrastructure

Company highlights Precigen is a clinical stage company with a growing portfolio of first-in-class

therapies Precigen is a biopharmaceutical company advancing the next generation of gene and cellular therapies using precision technology to target immuno-oncology, autoimmune disorders, and infectious diseases Diverse IP portfolio First-in-class

therapies Operational readiness Seasoned leadership Construct: UltraVector ; Three first-in-class products Experienced Established R&D and mbIL15 rapidly progressing towards management team to development

infrastructure clinic drive discovery and Deliver: Sleeping Beauty State-of-the-art facilities development system; AttSite PRGN-3006 UltraCAR-T recombinases; for AML, MDS-IND cleared 95+ clinicians, scientists

and AdenoVerse Dec 18 operational employees as of Dec 18 Control: RheoSwitch ; Kill PRGN-3005 UltraCAR-T switches; tissue specific for solid tumors promoters PRGN-2009 AdenoVerse vaccine for

Since our founding, Precigen has been evolving setting the stage for rapid advancement of clinical

programs Transition from ECC to Ziopharm agreement in-house model Merck KGaA agreement Focus on three core Oncology/Immuno-oncology therapeutic areas Autoimmune Disorders Infectious Diseases Build discovery and World class R&D facility

development engine All R&D functions in-house External PIs Build world-class bench Internal clinicians and scientists 6

Precigen infrastructure includes state-of-the-art facilities, growing manufacturing capabilities and in-house

R&D functions Infrastructure State-of-the-art R&D facility in Germantown, MD Building GMP manufacturing facility. Inauguration in 2019 All R&D functions established in-house Research Vivarium CMC Regulatory Clinical operations Program

Technology platforms o Technology platform advantages: CONSTRUCT, DELIVER, and CONTROL o UltraVector o

Sleeping Beauty system and AttSiteTM recombinases o AdenoVerseTM o RheoSwitch o Kill switches and tissue specific promoters

Precigen s technology platforms CONSTRUCT powerful gene UltraVector mbIL15 programs to drive efficacy

DELIVER Sleeping Beauty AttSiteTM gene programs via viral AdenoVerseTM and non-viral based system recombinases approaches to drive lower costs CONTROL Tissue specific gene expression and RheoSwitch Kill switches regulation to drives safety

UltraVector enables construction of powerful gene programs UltraVector enabled matrices facilitate

rapid Significant improvement in identification of components and configurations for gene expression optimal expression of multiple genes Optimized 250 gene expression CONSTRUCT PF P 5 ORF(s) 3 PF 200 Units 150 Relative 100 50 0 wt mature protein wt

3 REG CONTROL mock wt signal peptide wt 5 REG controls optimization constructs Industrialized assembly and screening of multigenic vectors DELIVER Optimized expression of multiple effector genes for precision medicine Viral and non-viral

(DNA, RNA and proteins) 10

Sleeping Beauty system is the most clinically advanced non-viral delivery method for stable gene expression

Non-viral Sleeping Beauty system offers a promising High efficiency of gene transfer alternative to expensive viral vectors for cell therapy CONSTRUCT(%) Expression Transposase Transgene(s) Transposon DELIVER Transposon CAR only UltraCAR-T

Multigenic -viral gene delivery platform Random integration with no insertion bias towards potentially dangerous loci CONTROL Continuous improvements to Sleeping Beauty system using UltraVector platform for optimized multigene delivery 11

AttSite recombinases enable non-viral delivery for stable gene expression for variety of cell types

AttSite recombinases unidirectionally target genes to AttSite recombinases facilitate integration at low CONSTRUCT predictable pseudosites in a host cell genome copy number into a finite number of pseudo AttSites AttSite Recombinase

Random DELIVER Integrants Precigen s next generation non-viral gene delivery platform Large payload capacity CONTROL Highly site specific integration at finite number of sites in a genome 12

AdenoVerse platform provides superior performance characteristics over Ad5 and other rare human and

non-human primate adenovirus A library of adenoviral vectors with diverse and unique Durable neutralizing antibody response CONSTRUCT DELIVER Large payload capacity Robust antigen specific T cell response Multigenic expression Control

of gene expression Superior performance of Gorilla adenovectors Low to no seroprevalence in the human population Ability for repeat administration CONTROL High-level and durable antigen-specific immune responses 13

Control of gene expression in vivo with RheoSwitch CONSTRUCT Switch OFF Switch ON (+activator ligand)

RheoSwitch contolled cytokine expression DELIVER by UltraCAR-T cells Turn in vivo using Highly controllable, oral ligand dose dependent gene expression CONTROL Clinically evaluated with excellent safety profile -2 -1 012

Log [Veledimex] (nM) 14

Kill switches and tissue specific promoters improve safety profile Kill switches Tissue specific promoters

CONSTRUCT 1 0 0 7 5 y t i c i x o t o 5 0 t y C % 2 5 0 Kill Switch Activator N e g a t i v e C o n t r o l tional local expression of effector genes 15

Therapeutic platform: UltraCAR-T

UltraCAR-T platform advantages: enhanced potency, safety, and scalability POTENCY SAFETY SCALABILITY

Multigenic expression Kill switch Rapid manufacturing Optimized CAR design Controlled gene Quick turnaround for expression with patients Long-term persistence RheoSwitch No ex vivo expansion Preferred/less Non-viral gene delivery differentiated

T cell Decentralized phenotype manufacturing 17

UltraCAR-T advantage: scalable manufacturing process with rapid turnaround time for patients mbIL15

improves potency of UltraCAR-T Memory like phenotype of UltraCAR-T mbIL15 Improved expansion and persistence of T cells Less differentiated, memory like T cell population Preferred phenotype Improved engraftment potential for

CAR-T cell generation Allows for elimination of ex vivo expansion manufacturing step 18

Disrupting the market: Precigen s transformative UltraCAR-T platform advancements TPrecigen s

-UltraCAR UltraCAR-T Platform enables patient reinfusion within two days following non-viral gene transfer 1 Leukapheresis 2 Electroporation 3 UltraCAR-T Infusion Less than two days Electroporatio Unmodified Sleeping Beauty UltraCAR-T cells T-cell

Plasmid DNA Leukapheresis and T cell isolation Electroporation of non-viral Sleeping Beauty for UltraCAR-T cells from patient expression of CAR, mbIL15 and kill switch expand in patients UltraCAR-T advancements UltraCAR-T Advantages : Potency +

Safety + Scalability 19

Preclinical and clinical portfolio o Portfolio designed for novel combinations o Current preclinical and

clinical portfolio by phase

Precigen s portfolio is designed to specifically deliver novel combinations 21

Precigen s pipeline offers rapid value creation and potential for novel combinations 22 TA Product

Platform Indication Discovery Preclinical Phase I PRGN-3006 UltraCAR-T AML, MDS INXN-3004 Viral CAR-T AML PRGN-3005 UltraCAR-T

Solid Tumors PRGN-3007 UltraCAR-T Undisclosed PRGN-3008 UltraCAR-T Undisclosed PRGN-2009 AdenoVerse Vaccine Solid Tumors PRGN-2010 AdenoVerse Vaccine Solid Tumors

PRGN-5001 Multifunctional Therapeutic Solid Tumors PRGN-2011 AdenoVerse Cytokine Therapy Solid Tumors PRGN-5002 Multifunctional Therapeutic Solid Tumors PRGN-2012 AdenoVerse Vaccine Undisclosed PRGN-2013 AdenoVerse Vaccine Undisclosed PRGN-3009

Undisclosed Undisclosed PRGN-3010 Undisclosed Undisclosed Immunooncology Infectious disease Autoimmune disorders Precigen pipeline as of January 2019

Precigen s portfolio is designed to deliver novel combinations in immunooncology 23 Multifunctional

Therapeutic Cytokine Therapeutic UltraCAR-T AdenoVerse Cancer Vaccine PRGN-3005 PRGN-3006 PRGN-3007 PRGN-3008 PRGN-2009 PRGN-2010 PRGN-5001 PRGN-5002 PRGN-2011 Novel combinations using

Precigen s portfolio programs Therapeutic Platforms Portfolio Programs UltraCAR-T UltraCAR-T UltraCAR-T

AdenoVerse Cancer Vaccine AdenoVerse Cancer Vaccine AdenoVerse Cancer Vaccine Multifunctional Therapeutic Multifunctional Therapeutic Cytokine Therapeutic Cytokine Therapeutic Cytokine Therapeutic Multifunctional Therapeutic

Immuno-oncology therapeutic area o Current immunotherapy landscape o Control of immuno-oncology technologies o

Asset highlight: PRGN-3006 UltraCAR-TTM o Asset highlight: PRGN-3005 UltraCAR-TTM o Asset highlight: AdenoVerseTM cancer vaccine o Asset highlight: Multifunctional

Current immunotherapy landscape has promise, but many drawbacks Despite the success, only a minority of

patients respond; in some indications there is no response Relapse rates are high among responders to checkpoint inhibitors Combination trials with checkpoint inhibitors have yielded only incremental advances at high cost Checkpoint Inhibitors

Immunotherapy with checkpoint inhibitors has revolutionized cancer treatment in recent years Viral-Based CAR-T Autologous Unparalleled clinical efficacy using anti CD19-CAR-T cells for treatment of refractory B-cell malignancies Reliance on viral vectors: complexity of manufacturing; potential safety concerns More differentiated

less desired T-cell phenotype Lengthy cell product manufacturing process Long delays for patients Major challenges in solid tumor treatments using current approaches Allogeneic Available on-demand Limited persistence / rejection of allogeneic CAR-T by host Short treatment window may limit effectiveness for solid tumors 25

Focus on immuno-oncology with full control of technologies Full developmental control across targets Royalty

bearing license to Ziopharm for CD19 and right to negotiate for second undisclosed target Exclusive rights to non-viral Sleeping Beauty system UltraCAR-T platform CAR-T cells Full developmental control across targets RheoSwitch Therapeutic System AdenoVerse platform Cancer vaccines Novel multi-effector therapeutics approach Multifunctional therapeutics Target

multiple pathways for improvement over existing checkpoint inhibitors Full developmental control across molecules Royalty bearing license to Ziopharm for controlled IL-12 viral therapy AdenoVerse

platform and RheoSwitch Therapeutic System Cytokine therapy Full developmental control across public antigen targets AttSite recombinases and viral gene delivery mbIL15 TCR T cells 26

Immuno-oncology therapeutic area Asset highlight: PRGN-3006

PRGN-3006 UltraCAR-T , a first-in-class therapy in AML, received FDA clearance for IND to initiate Phase 1/1b study 28 Autologous T cell investigational therapy Rapid manufacturing No ex vivo propagation step Infusion within 2 days

after gene transfer Next generation Sleeping Beauty design for optimized multigenic expression Highlights and Differentiation Relapsed or refractory acute myeloid leukemia (AML) Higher risk myelodysplastic syndrome (MDS) FDA IND clearance in Dec

18 Phase 1/1b study to evaluate safety and maximal tolerated dose expected to initiate in 1H 19 Study in collaboration with Moffitt Cancer Center Status Patient Population Non-viral Sleeping Beauty

system to coexpress CAR, mbIL15 and kill switch

PRGN-3006 UltraCAR-T exhibits enhanced functional activity and safety in vitro Enhanced cytotoxicity

Enhanced antigen specific 6 0 expansion y t i c 4 0 i N e g a t i v e C o n t r o l C A R - T x n o n e g o n e g t C A R - T ( m b I L 1 5 ) i C A R - T ( m b I L 1 5 ) o s t P R G N - 3 0 0 6 n P R G N - 3 0 0 6 y a C 2 0 p x % E 0 + + T a r g e t

n e g T a r g e t A M L T a r g e t A M L 0 5 1 0 1 5 2 0 C e l l L i n e 1 C e l l L i n e 2 C e l l L i n e T i m e ( D a y s ) No bystander activation Kill switch functionality 1 0 0 6 0 0 3 - 8 0 N Kill Switch Activator G Negative Control R P f

6 0 O y t i c i 4 0 x o t o t y C 2 0 % 0 P R G N - 3 0 0 6 29

PRGN-3006 UltraCAR-T cells eliminated tumor burden and improved

survival in an in vivo model of AML 30 Treatment Median OS (days) Saline 17 Negative Control CAR-T 17 CAR-T (mbIL15neg) 26 PRGN-3006 53 Anti-tumor activity Overall

survival (OS) PRGN-3006 UltraCAR-T cells administered in less than 2 days post gene transfer effectively eliminated AML tumor in dose dependent manner mbIL15 expression necessary for elimination of

aggressive AML tumor in mice Deceased Animal

mbIL15 improves expansion and persistence of PRGN-3006 UltraCAR-T

cells Superior in vivo expansion and persistence of PRGN-3006 UltraCAR-T cells in tumor bearing mice Expression of mbIL15 supports survival and promotes extended persistence in absence of cytokines 31

Enhanced survival In vivo AML model In vitro Enhanced expansion

Immuno-oncology therapeutic area Asset highlight: PRGN-3005

PRGN-3005 UltraCAR-T , a first-in-class therapy in solid tumors 33 Highlights and Differentiation Non-viral Sleeping Beauty system to coexpress CAR, mbIL15 and kill switch Autologous T cell