Intrexon Announces Fourth Quarter and Full Year 2015 Financial Results Quarterly revenues of $41.5 million and GAAP net loss of $32.7 million including non-cash charges of $19.4 million FY2015 Adjusted EBITDA of $53.4 mi

Intrexon Announces Fourth Quarter and Full Year 2015 Financial Results

Quarterly revenues of $41.5 million and GAAP net loss of $32.7 million

including non-cash charges of $19.4 million

FY2015 Adjusted EBITDA of $53.4 million

YTD consideration received for technology access fees, reimbursement of R&D services and product

and service revenues covered 133% of consolidated cash operating expenses

GERMANTOWN, MD, February 29, 2016 Intrexon Corporation (NYSE: XON), a leader in synthetic biology, today announced its fourth

quarter and full year results for 2015.

Business Highlights and Recent Developments:

Fourth Quarter Financial Highlights:

Full Year Financial Highlights:

Our essential strategy is accomplished when our team executes well, and in 2015 our team executed beautifully its mission to advance its leadership

position in the rapidly emergent field of engineered biology, commented Randal J. Kirk, Chairman and Chief Executive Officer of Intrexon. Our model has as its chief objective the attainment of a large portfolio of significant economic

interests in products across multiple industries while maintaining the discipline of living within our means, those being provided chiefly from our partners with whom we are working to develop world-changing products.

Mr. Kirk concluded, We are well positioned and excited as we look forward to the remainder of 2016, a year in which we intend to make progress along

three principal axes. First, extending the trend that we showed in 2015 over 2014, we expect to continue our financial growth trajectory. Second, we expect to deliver to the world in this year several examples of projects that were initiated within

our company, and these may include specimens from our methanotrophic bioconversion platform and clinical stage therapeutic candidates. Finally, we expect to partner some of our mature stage assets with companies that add real value toward their

maximized commercial realizations.

Fourth Quarter 2015 Financial Results Compared to Prior Year Period

Total revenues were $41.5 million for the quarter ended December 31, 2015 compared to $31.1 million for the quarter ended December 31, 2014, an

increase of $10.4 million, or 34%. Collaboration and licensing revenues increased $8.2 million over the three months ended December 31, 2014 due to (i) the recognition of deferred revenue for upfront payments received from the

Company s license and collaboration agreement with the biopharmaceutical business of Merck KGaA, which became effective in May 2015, and from other collaborations signed by Intrexon in 2015 and (ii) increased research and development

services for both new collaborations and for the expansion or addition of new programs with previously existing collaborators, including ZIOPHARM Oncology, Inc. (ZIOPHARM) and Intrexon s joint venture with Intrexon Energy Partners, LLC

(Intrexon Energy Partners). Product revenues were $9.2 million for the three months ended December 31, 2015 compared to $7.4 million for the three months ended December 31, 2014, an increase of $1.8 million, or 25%. The increase in product

revenues during the three months ended December 31, 2015 primarily relates to an increase in the quantity of pregnant cows and weaned calves sold due to higher customer demand. Gross margin on product revenues declined for the period due to a

decline in the average sales price and gross margins for sales of livestock previously used in production. Service revenues and gross margins remained consistent period over period.

Total operating expenses were $75.9 million for the quarter ended December 31, 2015 compared to $50.1 million for the quarter ended December 31,

2014, an increase of $25.8 million, or 51%. Research and development expenses were $26.2 million for the three months ended December 31, 2015 compared to $17.6 million for the three months ended December 31, 2014, an increase of $8.6

million, or 49 percent. Salaries, benefits and other personnel costs increased $3.6 million due to (i) an increase in research and development employees necessary to support new and expanded collaborations, (ii) the additional costs of

stock options and performance-based bonus awards for all research and development employees and (iii) the cost of new employees assumed as a result of Intrexon s various acquisitions. Lab supplies and contract research organizations

expenses increased $2.7 million as a result of (i) the progression of programs into the preclinical phase with certain of Intrexon s collaborators; (ii) the increased level of research and development services provided to the

Company s collaborators; and (iii) costs incurred as a result of the Company s various acquisitions. Depreciation and amortization increased $1.8 million primarily from the acquisition of property and equipment and intangible assets

assumed as a result of Intrexon s various acquisitions. Selling, general and administrative expenses were $34.7 million for the three months ended December 31, 2015 compared to $19.8 million for the three months ended December 31,

2014, an increase of $14.9 million, or 75 percent. Salaries, benefits and other personnel costs increased $10.5 million due to (i) an increase in selling, general and administrative employees necessary to support Intrexon s expanding

operations, (ii) the additional costs of stock

options and performance-based bonus awards, including those paid under the 2015 annual executive bonus plan, for all selling, general and administrative employees; (iii) the cost of new

employees assumed as a result of the Company s various acquisitions. Legal and professional expenses increased $2.9 million primarily due to (i) incremental legal and professional fees related to the ongoing operations of acquired

subsidiaries; and (ii) increased professional and business development expenses related to certain collaborations entered into during the three months ended December 31, 2015.

Total other income, net, was $3.7 million for the quarter ended December 31, 2015 compared to $38.5 million for the quarter ended December 31, 2014,

a decrease of $34.8 million, or 90%. This decrease was primarily related to the changes in the value of Intrexon s securities portfolio.

Year 2015 Financial Results Compared to Prior Year Period

Total revenues were $173.6 million for the year ended December 31, 2015 compared to

$71.9 million for the year ended December 31, 2014, an increase of $101.7 million, or 141%. For the year ended December 31, 2015, total product revenues of $41.9 million were derived primarily from the sale of pregnant cows, live calves

and livestock used in production and service revenues of $42.9 million were derived primarily from the provision of in vitro fertilization and embryo transfer services. For the year ended December 31, 2014, product and service revenues

were $11.5 million and $14.8 million, respectively. The increases relate primarily to the inclusion of a full year of results for Trans Ova in 2015 versus approximately five months of results for 2014. Collaboration and licensing revenues increased

$42.6 million over the year ended December 31, 2014 due to (i) the recognition of deferred revenue for upfront payments received from Intrexon s license and collaboration agreement with the biopharmaceutical business of Merck KGaA,

which became effective in May 2015, and from other collaborations signed by the Company in 2015; (ii) increased research and development services performed for both for new collaborations and for the expansion or addition of new programs with

previously existing collaborators, including primarily ZIOPHARM, Fibrocell Science, Inc., Genopaver, LLC, and Intrexon Energy Partners and (iii) the recognition of previously deferred revenue related to collaboration agreements for which

Intrexon satisfied all of its obligations or which were terminated during in 2015.

Total operating expenses were $320.5 million for the year ended

December 31, 2015 compared to $141.9 million for the year ended December 31, 2014, an increase of $178.6 million, or 126%. Research and development expenses were $147.5 million for the year ended December 31, 2015 compared to $59.0

million for the year ended December 31, 2014, an increase of $88.5 million, or 150%. In January 2015, Intrexon paid $59.6 million in common stock for an exclusive license to certain technologies owned by the University of Texas MD Anderson

Cancer Center, or MD Anderson. Salaries, benefits and other personnel costs increased $12.5 million due to (i) an increase in research and development employees necessary to support new and expanded collaborations, (ii) the additional

costs of stock options and performance-based bonus awards for all research and development employees; and (iii) the cost of new employees assumed as a result of Intrexon s various acquisitions. Lab supplies and contract research

organization expenses increased $8.2 million as a result of (i) the progression of programs into the preclinical phase with certain of Intrexon s collaborators; (ii) the increased level of research and development services provided to

the Company s collaborators; and (iii) costs incurred as a result of the Company s various acquisitions. Depreciation and amortization increased $4.0 million primarily from the acquisition of property and equipment and intangible

assets assumed as a result of Intrexon s various acquisitions. Selling, general and administrative expenses were $109.1 million for the year ended December 31, 2015 compared to $63.6 million for the year ended December 31, 2014, an

increase of $45.5 million, or 72%. Salaries, benefits and other personnel costs increased $28.0 million due to (i) the inclusion of selling, general and administrative employees of Trans Ova for a full year in 2015 compared to approximately

five months in 2014; (ii) an increase in selling, general and administrative employees necessary to support Intrexon s expanding operations, (iii) the additional costs of stock options and performance-based bonus awards, including

those paid under the 2015 annual executive bonus plan, for all selling, general and administrative employees; and (iv) the cost of new employees assumed as a result of the Company s various acquisitions. Legal and professional expenses

increased $7.0 million primarily due to costs associated with Intrexon s various 2015 acquisitions, the license agreement with MD Anderson, a full year of legal and professional costs for Trans Ova, Intrexon s 2015

public offerings, and other business development activity. Other selling, general and administrative expenses, including rent, utilities and depreciation and amortization, have increased in 2015

as a result of (i) the expansion of Intrexon s operations, including through the Company s various acquisitions, and (ii) a full year of Trans Ova expenses compared to approximately five months in 2014. Total operating expenses

for the year ended December 31, 2015 also include $63.9 million of products and services costs which primarily consist of employee compensation costs, livestock, feed, drug supplies, recipient costs and facility charges related to the

production of such products and services; this amount was $19.3 million for the year ended December 31, 2014. The increase relates primarily the inclusion of a full year of results for Trans Ova in 2015 versus five months of results for 2014.

Total other income, net, was $68.8 million for the year ended December 31, 2015 compared to total other expense, net, of $10.5 million for the year

ended December 31, 2014, an increase of $79.3 million. This increase was primarily related to the $81.4 million realized gain recognized upon the special stock dividend of all of Intrexon s shares of ZIOPHARM to Intrexon s

shareholders in June 2015.

Conference Call and Webcast

The Company will host a conference call on Monday, February 29th, at 5:30 PM EST to discuss the

fourth quarter and full year 2015 financial results and provide a general business update. The conference call may be accessed by dialing 1-888-317-6003 (Domestic US) and 1-412-317-6061 (International) and providing the Elite Entry

number 1917410 to join the Intrexon Corporation Call. Participants may also access the live webcast through Intrexon s website in the Investors section at http://investors.dna.com/events.

About Intrexon Corporation

Intrexon Corporation (NYSE:

XON) is Powering the Bioindustrial Revolution with Better DNA to create biologically-based products that improve the quality of life and the health of the planet. Intrexon s integrated technology suite provides its partners across diverse

markets with industrial-scale design and development of complex biological systems delivering unprecedented control, quality, function, and performance of living cells. We call our synthetic biology approach Better DNA , and we invite you to discover more at www.dna.com.

Non-GAAP Financial Measures

This press release presents Adjusted EBITDA and Adjusted EBITDA per share, which are non-GAAP financial measures within the meaning of applicable

rules and regulations of the Securities and Exchange Commission (SEC). For a reconciliation of these measures to the most directly comparable financial measure calculated in accordance with generally accepted accounting principles and for a

discussion of the reasons why the company believes that these non-GAAP financial measures provide information that is useful to investors see the tables below under Reconciliation of GAAP to Non-GAAP Measures. Such information is

provided as additional information, not as an alternative to Intrexon s consolidated financial statements presented in accordance with GAAP, and is intended to enhance an overall understanding of the Intrexon s current financial

Intrexon, ActoBiotics,

Powering the Bioindustrial Revolution with Better DNA, and Better DNA are trademarks of Intrexon and/or its affiliates. Other names may be trademarks of their respective owners.

Safe Harbor Statement

Some of the statements made in

this press release are forward-looking statements that involve a number of risks and uncertainties and are made pursuant to the Safe harbor Provisions of the Private Securities Litigation Reform Act of 1995. These forward-looking statements are

based upon Intrexon s current expectations and projections about future events and generally relate to Intrexon s plans, objectives and expectations for the development of Intrexon s business. Although management believes that

the plans and objectives reflected in or suggested by these forward-looking statements are reasonable, all forward-looking statements involve risks

and uncertainties and actual future results may be materially different from the plans, objectives and expectations expressed in this press release. These risks and uncertainties include, but are

not limited to, (i) Intrexon s current and future ECCs and joint ventures; (ii) Intrexon s ability to successfully enter new markets or develop additional products, whether with its collaborators or independently;

(iii) actual or anticipated variations in Intrexon s operating results; (iv) actual or anticipated fluctuations in Intrexon s competitors or its collaborators operating results or changes in their respective growth

rates; (v) Intrexon s cash position; (vi) market conditions in Intrexon s industry; (vii) Intrexon s ability, and the ability of its collaborators, to protect Intrexon s intellectual property and other proprietary

rights and technologies; (viii) Intrexon s ability, and the ability of its collaborators, to adapt to changes in laws or regulations and policies; (ix) the rate and degree of market acceptance of any products developed by a

collaborator under an ECC or through a joint venture; (x) Intrexon s ability to retain and recruit key personnel; (xi) Intrexon s expectations related to the use of proceeds from its public offerings and other financing efforts;

(xii) Intrexon s estimates regarding expenses, future revenue, capital requirements and needs for additional financing; and (xiii) Intrexon s expectations relating to its subsidiaries and other affiliates. For a discussion of

other risks and uncertainties, and other important factors, any of which could cause Intrexon s actual results to differ from those contained in the forward-looking statements, see the section entitled Risk Factors in

Intrexon s Annual Report on Form 10-K, its Quarterly Report on Form 10-Q for the period ended September 30, 2015, as well as discussions of potential risks, uncertainties, and other important factors in Intrexon s subsequent filings

with the Securities and Exchange Commission. All information in this press release is as of the date of the release, and Intrexon undertakes no duty to update this information unless required by law.

For more information regarding Intrexon

Corporation, contact: