Full Press Release Details
Pfizer Reports Solid Full-Year 2025 Results And Reaffirms 2026 Guidance
Focused Execution Drives Strong Full-Year 2025 EPS Performance
Enters 2026 with Clear Strategic Priorities and Growing Late Stage Pipeline
Advanced 11 Key Pivotal Study Starts in 2025 and 20 Key Pivotal Study Starts Planned for 2026
NEW YORK, Tuesday, February 3, 2026 - Pfizer Inc. (NYSE PFE) reported financial results for fourth-quarter and full-year 2025 and reaffirmed its full-year 2026 financial guidance(1) provided on December 16, 2025.
EXECUTIVE COMMENTARY
Dr. Albert Bourla, Chairman and CEO of Pfizer
"With excellent execution in 2025, we delivered a solid financial performance and strengthened Pfizer's foundation for future growth. Looking ahead, 2026 will be an important year rich in key catalysts, including our expectation for approximately 20 key pivotal study starts, and continued strategic investment to maximize our opportunities for industry-leading growth at the end of the decade."
David Denton, CFO and EVP of Pfizer
"I'm pleased with our solid financial results in 2025. With focused commercial execution, we delivered full-year operational revenue growth of 6% for our non-COVID portfolio, and our continued financial discipline drove strong EPS performance. Today, we are reaffirming our full-year 2026 financial guidance."
Full-Year 2025 Revenues of $62.6 Billion, Reflecting a 2% Year-over-Year Operational Decline
-Excluding Contributions from Paxlovid and Comirnaty, Revenues Grew 6% Operationally
Full-Year 2025 Reported(2) Diluted EPS of $1.36 and Adjusted(3) Diluted EPS of $3.22
Fourth-Quarter 2025 Revenues of $17.6 Billion, Representing a 3% Year-over-Year Operational Decline
-Excluding Contributions from Paxlovid and Comirnaty, Revenues Grew 9% Operationally
Fourth-Quarter 2025 Reported(2) Diluted Loss Per Share (LPS) of $(0.29) and Adjusted(3) Diluted EPS of $0.66
Reaffirms All Components of Full-Year 2026 Financial Guidance(1), including Revenues in a Range of $59.5 to $62.5 Billion and Adjusted(3) Diluted EPS in a Range of $2.80 to $3.00
Some amounts in this press release may not add due to rounding. All percentages have been calculated using unrounded amounts. References to operational variances pertain to period-over-period changes that exclude the impact of foreign exchange rates(4).
Results for the fourth quarter and full year of 2025 and 2024(5) are summarized below.
| ($ in millions, except per share amounts) | Fourth-Quarter | Full-Year | |||||||||
| 2025 | 2024 | % Change | 2025 | 2024 | % Change | ||||||
| Revenues | $ 17,557 | $ 17,763 | (1%) | $ 62,579 | $ 63,627 | (2%) | |||||
| Reported (2) Net Income (Loss) | (1,648) | 410 | * | 7,771 | 8,031 | (3%) | |||||
| Reported (2) Diluted EPS (LPS) | (0.29) | 0.07 | * | 1.36 | 1.41 | (3%) | |||||
| Adjusted (3) Income | 3,786 | 3,592 | 5% | 18,406 | 17,716 | 4% | |||||
| Adjusted (3) Diluted EPS | 0.66 | 0.63 | 5% | 3.22 | 3.11 | 4% | |||||
| * Indicates calculation not meaningful or results are greater than 100%. |
| ($ in millions) | Fourth-Quarter | Full-Year | |||||||||||
| 2025 | 2024 | % Change | 2025 | 2024 | % Change | ||||||||
| Total | Oper. | Total | Oper. | ||||||||||
| Global Biopharmaceuticals Business (Biopharma) | $ 17,144 | $ 17,413 | (2%) | (3%) | $ 61,199 | $ 62,400 | (2%) | (2%) | |||||
| Pfizer CentreOne (PC1) | 409 | 325 | 26% | 22% | 1,338 | 1,146 | 17% | 15% | |||||
| Pfizer Ignite | 4 | 26 | (83%) | (83%) | 41 | 82 | (50%) | (50%) | |||||
| TOTAL REVENUES | $ 17,557 | $ 17,763 | (1%) | (3%) | $ 62,579 | $ 63,627 | (2%) | (2%) |
2026 FINANCIAL GUIDANCE(1)
Reaffirms full-year 2026 Revenue guidance in a range of $59.5 to $62.5 billion and Adjusted(3) diluted EPS guidance(1) in a range of $2.80 to $3.00.
The reaffirmed 2026 Revenue guidance reflects the expectation of approximately $5 billion in revenues from our COVID-19 products and an expected year-over-year negative revenue impact of approximately $1.5 billion due to certain products experiencing loss of exclusivity (LOE)(1).
2026 Adjusted(3) diluted EPS guidance primarily reflects our expected revenues, anticipated stable gross and operating margins versus full-year 2025, and an anticipated higher tax rate on Adjusted(3) income versus full-year 2025. Additionally, our guidance reflects our expectation for a continued focus on prioritization in key therapeutic areas as well as our plan to start approximately 20 key pivotal trials in 2026, including ten pivotal trials for ultra-long-acting obesity assets acquired from Metsera and four pivotal trials for PF-08634404 (a PD-1 x VEGF bispecific antibody in-licensed from 3SBio).
The company's guidance reflects the anticipated unfavorable impact of Most-Favored-Nation drug pricing and TrumpRx.
The company's guidance includes the anticipated impact of currently imposed tariffs.
| Revenues | $59.5 to $62.5 billion | ||
| Adjusted (3) SI A Expenses | $12.5 to $13.5 billion | ||
| Adjusted (3) R D Expenses | $10.5 to $11.5 billion | ||
| Effective Tax Rate on Adjusted (3) Income | Approximately 15.0% | ||
| Adjusted (3) Diluted EPS | $2.80 to $3.00 |
In 2025, Pfizer deployed its capital in a variety of ways, which primarily included
Reinvesting capital into initiatives intended to enhance the future growth prospects of the company, including
$10.4 billion invested in internal research and development projects, and
Approximately $8.8 billion invested in business development transactions, primarily reflecting the Metsera acquisition and the 3SBio in-licensing deal.
Returning capital directly to shareholders through $9.8 billion of cash dividends, or $1.72 per share of common stock.
Our capital allocation framework is designed to enhance long-term shareholder value, and is based on three core pillars (i) maintaining and, over the long term, growing our dividend, (ii) reinvesting in the business, including maintaining the flexibility to deploy capital towards potential value-creating business development transactions, and (iii) in the future, the potential to resume the return of capital to shareholders through value-enhancing share repurchases. The company expects to continue to de-lever over the longer term in a prudent manner in order to maintain a balanced capital allocation strategy.
No share repurchases were completed in 2025. As of February 3, 2026, Pfizer's remaining share repurchase authorization is $3.3 billion. Current financial guidance does not anticipate any share repurchases in 2026.
For the fourth quarter of 2025, basic weighted-average shares outstanding of 5,686 million were used to calculate Reported(2) LPS and diluted weighted-average shares outstanding of 5,722 million were used to calculate Adjusted(3) diluted EPS.
QUARTERLY FINANCIAL HIGHLIGHTS (Fourth-Quarter 2025 vs. Fourth-Quarter 2024)
Fourth-quarter 2025 revenues totaled $17.6 billion, a decrease of $206 million, or 1%, compared to the prior-year quarter, reflecting an operational decrease of $484 million, or 3%, and a favorable impact of foreign exchange of $278 million. The operational decrease was primarily driven by a year-over-year decline in COVID-19 product revenues, partially offset by an increase in revenues for Abrysvo, Oncology biosimilars, Eliquis, the Prevnar family, the Vyndaqel family, and several other products across categories. Excluding contributions from Comirnaty and Paxlovid, revenues for the fourth quarter grew 9% operationally.
Fourth-quarter 2025 operational revenue reflected higher revenues primarily for
Abrysvo globally, up 136% (or up $270 million) operationally, driven primarily by launch uptake for both the adult and maternal indications in certain international markets, as well as favorable net price and market share for the adult indication in the U.S. partially offset by lower vaccination rates for the older adult indication in the U.S. following an updated recommendation by the Advisory Committee on Immunization Practices
Oncology biosimilars globally, up 76% operationally, driven primarily by favorable net price in the U.S.
Eliquis globally, up 8% operationally, driven primarily by higher demand globally and, as anticipated, favorable net price in the U.S. as a result of the year-over-year impact of the elimination of the coverage gap as part of the IRA Medicare Part D Redesign partially offset by a reduction in sales due to lower inventory in the U.S. distribution channel related to year-end buying patterns, as well as generic entry and price erosion in certain international markets
Prevnar family globally, up 8% operationally, driven primarily by strong uptake of the adult indication in certain international markets, coupled with continued uptake of the adult indication in the U.S. as a result of strong demand following the U.S. Centers for Disease Control and Prevention (CDC) recommendation for
ages 50-64 partially offset by lower market share in the U.S. and timing of shipments in certain international markets
Vyndaqel family (Vyndaqel, Vyndamax, Vynmac) globally, up 7% operationally, driven largely by strong demand with continuing uptake in patient diagnosis primarily in the U.S. and certain international developed markets, as well as improved patient affordability in the U.S. partially offset by lower net price in the U.S. due to the impact of higher manufacturer discounts resulting from the IRA Medicare Part D Redesign and, to a lesser extent, new payer contracts with reduced pricing
Lorbrena globally, up 45% operationally, driven primarily by increased patient share in the first-line ALK-positive metastatic non-small cell lung cancer (ALK+ mNSCLC) treatment setting in the U.S., China, and certain other international markets, partially offset by lower net price in the U.S. mainly due to the impact of higher manufacturer discounts resulting from the IRA Medicare Part D redesign and
Padcev globally, up 15% operationally, driven primarily by increased market share in first-line locally advanced or metastatic urothelial cancer (la mUC)
more than offset primarily by lower revenues for
Comirnaty globally, down 35% operationally, driven primarily by a decline in international markets from both lower contractual deliveries and lower vaccination rates in commercial markets, as well as lower utilization in the U.S. resulting from a narrower recommendation for vaccination and
Paxlovid globally, down 70% operationally, driven primarily by lower COVID-19 infections across U.S. and international markets and lower international government purchases partially offset by higher net price in the U.S. following transition from the U.S. government agreement.
GAAP Reported(2) Statement of Operations Highlights
SELECTED REPORTED(2) COSTS AND EXPENSES
| ($ in millions) | Fourth-Quarter | Full-Year | ||||||||||||
| 2025 | 2024 | % Change | 2025 | 2024 | % Change | |||||||||
| Total | Oper. | Total | Oper. | |||||||||||
| Cost of Sales (2) | $ 5,272 | $ 5,909 | (11%) | (14%) | $ 16,067 | $ 17,851 | (10%) | (12%) | ||||||
| Percent of Revenues | 30.0 | % | 33.3 | % | N A | N A | 25.7 | % | 28.1 | % | N A | N A | ||
| SI A Expenses (2) | 4,162 | 4,274 | (3%) | (3%) | 13,794 | 14,730 | (6%) | (7%) | ||||||
| R D Expenses (2) | 3,206 | 3,035 | 6% | 5% | 10,437 | 10,822 | (4%) | (4%) | ||||||
| Acquired IPR D Expenses (2) | 212 | 88 | * | * | 1,613 | 108 | * | * | ||||||
| Other (Income) Deductions-net (2) | 4,514 | 2,358 | 91% | 94% | 6,724 | 4,388 | 53% | 55% | ||||||
| Effective Tax Rate on Reported (2) Income (Loss) | 0.1 | % | * | (3.5 | %) | (0.4%) | ||||||||
| * Indicates calculation not meaningful or results are greater than 100%. |
Fourth-quarter 2025 Cost of Sales(2) as a percentage of revenues decreased by 3.2 percentage points compared to the prior-year quarter, primarily driven by (i) a favorable change in sales mix including lower sales of Comirnaty, and (ii) lower amortization from the step-up of acquired inventory partially offset by (iii) an unfavorable impact of foreign exchange and (iv) a lower favorable revision of our estimate of accrued royalties in the fourth quarter of 2025 compared to the prior-year quarter.
Fourth-quarter 2025 SI A Expenses(2) decreased 3% operationally compared to the prior-year quarter, primarily reflecting focused investments and ongoing productivity improvements that drove a decrease in marketing and promotional spend for various products and lower spending in corporate enabling functions, partially offset by an increase in liabilities payable to participants of our supplemental savings plan.
Fourth-quarter 2025 R D Expenses(2) increased 5% operationally compared to the prior-year quarter, driven primarily by an increase in spending in oncology and obesity product candidates, partially offset by a net decrease in spending due to pipeline focus and optimization including the expansion of our digital capabilities.
Fourth-quarter 2025 Acquired In-Process R D Expenses(2) increased $124 million compared to the prior-year quarter, driven primarily by a $150 million charge related to an in-licensing agreement with YaoPharma.
The unfavorable period-over-period change in Other (income) deductions-net(2) of $2.2 billion for the fourth quarter of 2025, compared to the prior-year quarter, was driven primarily by (i) higher intangible asset impairment charges in the fourth quarter of 2025, (ii) lower net gains on equity securities and (iii) the non-recurrence of gains on the partial sale of our previous investment in Haleon plc (Haleon) equity in the fourth quarter of 2024 partially offset by (iv) net periodic benefit credits associated with pension and postretirement plans incurred in the fourth quarter of 2025 versus net periodic benefit costs incurred in the fourth quarter of 2024. Included in Other (income) deductions-net(2) are total non-cash intangible asset impairment charges of $4.4 billion that were taken in the fourth quarter of 2025 due to changes in development plans and updated long-range commercial forecasts.
Pfizer's effective tax rate on Reported(2) loss for the fourth quarter of 2025 reflects the jurisdictional mix of earnings as well as resolutions with tax authorities.
Adjusted(3) Statement of Operations Highlights
SELECTED ADJUSTED(3) COSTS AND EXPENSES
| ($ in millions) | Fourth-Quarter | Full-Year | ||||||||||||
| 2025 | 2024 | % Change | 2025 | 2024 | % Change | |||||||||
| Total | Oper. | Total | Oper. | |||||||||||
| Adjusted (3) Cost of Sales | $ 5,066 | $ 5,742 | (12%) | (15%) | $ 15,141 | $ 16,420 | (8%) | (9%) | ||||||
| Percent of Revenues | 28.9 | % | 32.3 | % | N A | N A | 24.2 | % | 25.8 | % | N A | N A | ||
| Adjusted (3) SI A Expenses | 4,080 | 4,275 | (5%) | (5%) | 13,642 | 14,617 | (7%) | (7%) | ||||||
| Adjusted (3) R D Expenses | 3,116 | 2,986 | 4% | 4% | 10,212 | 10,694 | (5%) | (5%) | ||||||
| Acquired IPR D Expenses (3) | 212 | 88 | * | * | 1,613 | 108 | * | * | ||||||
| Adjusted (3) Other (Income) Deductions-net | 139 | 234 | (41%) | (16%) | 827 | 1,031 | (20%) | (11%) | ||||||
| Effective Tax Rate on Adjusted (3) Income | 23.3% | 18.9 | % | 12.7 | % | 14.5 | % | |||||||
| * Indicates calculation not meaningful or results are greater than 100%. |
See the reconciliations of certain Reported(2) to non-GAAP Adjusted(3) financial measures and associated footnotes in the financial tables section of this press release.
FULL-YEAR REVENUE SUMMARY (Full-Year 2025 vs. Full-Year 2024)
Full-year 2025 revenues totaled $62.6 billion, a decrease of $1.0 billion, or 2%, compared to full-year 2024, reflecting an operational decrease of $1.3 billion, or 2%, partially offset by a favorable impact of foreign exchange of $247 million. Excluding contributions from Comirnaty and Paxlovid, revenues for the full-year grew 6% operationally.
The operational decrease was primarily driven by a year-over-year decline in COVID-19 product revenues largely due to lower infection rates impacting Paxlovid demand as well as a narrower vaccine recommendation for COVID-19 in the U.S. impacting Comirnaty sales partially offset by growth contributions led by the Vyndaqel family, Eliquis, Padcev, Lorbrena, Abrysvo, and Oncology biosimilars.
RECENT NOTABLE DEVELOPMENTS (Since November 4, 2025)
Product Developments
| Product Project | Milestone | Recent Development | Link |
| Braftovi (encorafenib) | Phase 3 Results | January 2026. Announced positive results from Cohort 3, a separate, investigational randomized cohort of the pivotal BREAKWATER trial, evaluating Braftovi in combination with cetuximab and FOLFIRI (fluorouracil, leucovorin, and irinotecan) in patients with previously untreated metastatic colorectal cancer (mCRC) with a BRAF V600E mutation. At the time of analysis, the Braftovi combination regimen with FOLFIRI and cetuximab demonstrated a clinically meaningful and statistically significant improvement in confirmed objective response rate (ORR), as assessed by BICR, compared to patients receiving standard-of-care treatment FOLFIRI with or without bevacizumab (64.4% vs 39.2%, odds ratio 2.76, p 0.001). The safety profile of Braftovi in combination with cetuximab and FOLFIRI was consistent with the known safety profile of each respective agent. | Full Release |
| Hympavzi (marstacimab) | Phase 3 Results | December 2025. Announced detailed results from the Phase 3 BASIS study (NCT03938792) evaluating Hympavzi for adults and adolescents living with hemophilia A or B with inhibitors that demonstrated the superiority of investigational use of Hympavzi in improving key bleeding outcomes compared to on-demand (OD) treatment with bypassing agents. | Full Release |
| Product Project | Milestone | Recent Development | Link |
| Padcev (enfortumab vedotin) | Phase 3 Results | December 2025. Pfizer and Astellas Pharma Inc. (Astellas) announced positive topline results from an interim analysis of the Phase 3 EV-304 clinical trial (also known as KEYNOTE-B15) for Padcev in combination with pembrolizumab. The pivotal study is evaluating the combination as neoadjuvant and adjuvant treatment (before and after surgery) versus standard of care neoadjuvant chemotherapy (gemcitabine and cisplatin) in patients with muscle-invasive bladder cancer (MIBC) who are eligible for cisplatin-based chemotherapy. The trial met its primary endpoint, demonstrating clinically meaningful and statistically significant improvements in event-free survival (EFS), and overall survival (OS), a key secondary endpoint. An additional secondary endpoint of pathologic complete response (pCR) rate for neoadjuvant Padcev plus pembrolizumab versus neoadjuvant chemotherapy was also met, and a clinically meaningful and statistically significant improvement was observed. The safety profile for Padcev plus pembrolizumab was consistent with the known profile of the treatment regimen. | Full Release |
| Regulatory | December 2025. Astellas announced the European Medicines Agency (EMA) validated for review a Type II variation application for Padcev in combination with pembrolizumab, as neoadjuvant treatment (before surgery), and then continued after radical cystectomy (surgery) as adjuvant treatment (after surgery), for adults with MIBC who are ineligible for cisplatin-containing chemotherapy. The EMA's Committee for Medicinal Products for Human Use and subsequently the European Commission are expected to share their opinion and decision in 2026. | Full Release | |
| Regulatory | November 2025. Pfizer and Astellas announced the U.S. Food and Drug Administration (FDA) approved Padcev in combination with pembrolizumab or pembrolizumab and berahyaluronidase alfa-pmph as neoadjuvant treatment and then continued after cystectomy (surgery) as adjuvant treatment for adult patients with MIBC who are ineligible for cisplatin-containing chemotherapy. The approval of this perioperative (before and after surgery) treatment was based on results from the pivotal Phase 3 EV-303 clinical trial (also known as KEYNOTE-905). | Full Release | |
| Tukysa (tucatinib) | Phase 3 Results | December 2025. Announced detailed results from the Phase 3 HER2CLIMB-05 trial of Tukysa as part of an investigational first-line maintenance treatment combination, following chemotherapy-based induction, in patients with human epidermal growth factor receptor 2-positive (HER2+) metastatic breast cancer (MBC). The primary endpoint analysis showed a 35.9% reduction in the risk of disease progression or death among patients treated with Tukysa, trastuzumab, and pertuzumab compared to those treated with placebo, trastuzumab, and pertuzumab, as assessed by the investigator (hazard ratio HR of 0.641, 95% confidence interval (CI) 0.514-0.799 2-sided p 0.0001). The combination demonstrated a manageable safety profile as a first-line maintenance therapy. | Full Release |
Pipeline Developments
A comprehensive update of Pfizer's development pipeline was published today and is now available at www.pfizer.com science drug-product-pipeline. It includes an overview of Pfizer's research and a list of compounds in development with targeted indication and phase of development, as well as mechanism of action for some candidates in Phase 1 and all candidates from Phase 2 through registration.
| Product Project | Milestone | Recent Development | Link |
| Ultra-Long-Acting GLP-1 (PF'3944 MET-097i) | Phase 2b Results | February 2026. Announced positive topline results from the Phase 2b VESPER-3 study investigating monthly maintenance dosing of the fully-biased, ultra-long-acting, injectable GLP-1 receptor agonist PF'3944 (MET-097i) in adults with obesity or overweight without type 2 diabetes. The study met its primary endpoint of statistically significant weight reduction at 28 weeks and demonstrated a competitive tolerability profile. Additionally, weight loss continued after the pre-planned switch from weekly to monthly dosing, with no plateau observed at 28 weeks. Detailed results from VESPER-3 will be presented on June 6, 2026 at the 86th Scientific Sessions of the American Diabetes Association . | Full Release |
Corporate Developments
| Topic | Recent Development | Link |
| Business Development | December 2025. Announced an exclusive global collaboration and in-license agreement with YaoPharma, a leading innovation-driven global healthcare company, for the development, manufacturing and commercialization of YP05002, a small molecule glucagon-like peptide 1 (GLP-1) receptor agonist currently in Phase 1 development for chronic weight management. Under the terms of the agreement, YaoPharma will complete an ongoing YP05002 Phase 1 clinical trial and granted Pfizer an exclusive license to further develop, manufacture and commercialize YP05002 worldwide. YaoPharma received an upfront payment of $150 million and is eligible to receive milestone payments associated with certain development, regulatory and commercial milestones up to $1.935 billion, as well as tiered royalties on sales, if approved. | Full Release |
| November 2025. Announced the completion of Pfizer's acquisition of all outstanding shares of common stock of Metsera, a clinical-stage biopharmaceutical company accelerating the next generation of medicines for obesity and cardiometabolic diseases, for $65.60 in cash per Metsera share, representing an enterprise value of approximately $7.0 billion. Additionally, Metsera shareholders were granted a contingent value right (CVR) of up to $20.65 per share of Metsera stock in potential additional payments tied to the achievement of three specified clinical and regulatory milestones. | Full Release | |
| ViiV Healthcare Limited | January 2026. Pfizer reached an agreement with GSK plc and Shionogi Co., Ltd to exit its 11.7% investment in ViiV Healthcare Limited. Under the terms of the agreement, Pfizer will receive $1.875 billion in cash. Completion of the transaction is expected to occur in the first quarter of 2026, subject to certain regulatory clearances in relevant markets. | N A |
PFIZER TO HOST CONFERENCE CALL
Pfizer will host a live conference call and webcast today, February 3, 2026, at 10 00 AM EST. To access the live conference call, the fourth-quarter 2025 earnings presentation, and the accompanying prepared remarks from management, visit our website at pfizer.com investors.
You can also listen to the conference call by dialing either 800-456-4352 in the U.S. and Canada or 785-424-1086 outside of the U.S. and Canada. The passcode is "10856".
The transcript and webcast replay of the call will be made available on our website at pfizer.com investors within 24 hours after the end of the live conference call and will be accessible for at least 90 days.
For additional details, see the attached financial schedules, product revenue tables and disclosure notice.
(1)Pfizer does not provide guidance for U.S. generally accepted accounting principles (GAAP) Reported financial measures (other than revenues) or a reconciliation of forward-looking non-GAAP financial measures to the most directly comparable GAAP Reported financial measures on a forward-looking basis because it is unable to predict with reasonable certainty the ultimate outcome of unusual gains and losses, certain acquisition-related expenses, gains and losses from equity securities, actuarial gains and losses from pension and postretirement plan remeasurements, potential future asset impairments and pending litigation without unreasonable effort. These items are uncertain, depend on various factors, and could have a material impact on GAAP Reported results for the guidance period.
Financial guidance for full-year 2026 reflects the following
Does not assume the completion of any business development transactions not completed as of February 3, 2026.
An anticipated unfavorable revenue impact of approximately $1.5 billion due to recent and expected generic and biosimilar competition for certain products that have recently lost patent or regulatory protection or that are anticipated to lose patent or regulatory protection.
Exchange rates assumed are actual rates at mid-January 2026.
Guidance for Adjusted(3) diluted EPS assumes diluted weighted-average shares outstanding of approximately 5.74 billion shares, and assumes no share repurchases in 2026.
(2)Revenues is defined as revenues in accordance with U.S. GAAP. Reported net income (loss) and its components are defined as net income (loss) attributable to Pfizer Inc. common shareholders and its components in accordance with U.S. GAAP. Reported diluted EPS and reported diluted LPS are defined as diluted EPS or LPS attributable to Pfizer Inc. common shareholders in accordance with U.S. GAAP.
(3)Adjusted income and Adjusted diluted earnings per share (EPS) are defined as U.S. GAAP net income (loss) attributable to Pfizer Inc. common shareholders and U.S. GAAP diluted EPS (LPS) attributable to Pfizer Inc. common shareholders before the impact of amortization of intangible assets, certain acquisition-related items, discontinued operations and certain significant items. See the accompanying reconciliations of certain GAAP Reported to Non-GAAP Adjusted information for the fourth quarter and full-year 2025 and 2024. Adjusted income and its components and Adjusted diluted EPS measures are not, and should not be viewed as, substitutes for U.S. GAAP net income (loss) and its components and diluted EPS (LPS)(2). See the Non-GAAP Financial Measure Adjusted Income section of Management's Discussion and Analysis of Financial Condition and Results of Operations in Pfizer's 2024 Annual Report on Form 10-K and the accompanying Non-GAAP Financial Measure Adjusted Income section of this press release for a definition of each component of Adjusted income as well as other relevant information.
(4)References to operational variances in this press release pertain to period-over-period changes that exclude the impact of foreign exchange rates. Although foreign exchange rate changes are part of Pfizer's business, they are not within Pfizer's control and because they can mask positive or negative trends in the
business, Pfizer believes presenting operational variances excluding these foreign exchange changes provides useful information to evaluate Pfizer's results.
(5)Pfizer's fiscal year-end for international subsidiaries is November 30 while Pfizer's fiscal year-end for U.S. subsidiaries is December 31. Therefore, Pfizer's fourth quarter and full year for U.S. subsidiaries reflects the three and twelve months ended on December 31, 2025 and December 31, 2024, while Pfizer's fourth quarter and full year for subsidiaries operating outside the U.S. reflects the three and twelve months ended on November 30, 2025 and November 30, 2024.
PFIZER INC. AND SUBSIDIARY COMPANIES
CONSOLIDATED STATEMENTS OF OPERATIONS(1)
(millions, except per share data)
| Fourth-Quarter | % Incr. | Full-Year | % Incr. | |||||||||||||||||
| 2025 | 2024 | (Decr.) | 2025 | 2024 | (Decr.) | |||||||||||||||
| Revenues | ||||||||||||||||||||
| Product revenues (2) | $ | 14,496 | $ | 15,084 | (4) | $ | 51,663 | $ | 53,816 | (4) | ||||||||||
| Alliance revenues | 2,582 | 2,248 | 15 | 9,266 | 8,388 | 10 | ||||||||||||||
| Royalty revenues | 480 | 431 | 11 | 1,650 | 1,423 | 16 | ||||||||||||||
| Total revenues | 17,557 | 17,763 | (1) | 62,579 | 63,627 | (2) | ||||||||||||||
| Costs and expenses | ||||||||||||||||||||
| Cost of sales (2), (3) | 5,272 | 5,909 | (11) | 16,067 | 17,851 | (10) | ||||||||||||||
| Selling, informational and administrative expenses (3) | 4,162 | 4,274 | (3) | 13,794 | 14,730 | (6) | ||||||||||||||
| Research and development expenses (3) | 3,206 | 3,035 | 6 | 10,437 | 10,822 | (4) | ||||||||||||||
| Acquired in-process research and development expenses (4) | 212 | 88 | * | 1,613 | 108 | * | ||||||||||||||
| Amortization of intangible assets | 1,229 | 1,359 | (10) | 4,874 | 5,286 | (8) | ||||||||||||||
| Restructuring charges and certain acquisition-related costs (5) | 604 | 750 | (19) | 1,550 | 2,419 | (36) | ||||||||||||||
| Other (income) deductions--net (6) | 4,514 | 2,358 | 91 | 6,724 | 4,388 | 53 | ||||||||||||||
| Income (loss) from continuing operations before provision (benefit) for taxes on income (loss) | (1,642) | (10) | * | 7,520 | 8,023 | (6) | ||||||||||||||
| Provision (benefit) for taxes on income (loss) (7) | (2) | (421) | (99) | (266) | (28) | * | ||||||||||||||
| Income (loss) from continuing operations | (1,640) | 411 | * | 7,787 | 8,051 | (3) | ||||||||||||||
| Discontinued operations--net of tax | - | 7 | (98) | 25 | 11 | * | ||||||||||||||
| Net income (loss) before allocation to noncontrolling interests | (1,640) | 418 | * | 7,812 | 8,062 | (3) | ||||||||||||||
| Less Net income attributable to noncontrolling interests | 8 | 8 | (1) | 41 | 31 | 33 | ||||||||||||||
| Net income (loss) attributable to Pfizer Inc. common shareholders | $ | (1,648) | $ | 410 | * | $ | 7,771 | $ | 8,031 | (3) | ||||||||||
| Earnings (loss) per common share--basic | ||||||||||||||||||||
| Income (loss) from continuing operations attributable to Pfizer Inc. common shareholders | $ | (0.29) | $ | 0.07 | * | $ | 1.37 | $ | 1.42 | (4) | ||||||||||
| Discontinued operations--net of tax | - | - | - | - | - | - | ||||||||||||||
| Net income (loss) attributable to Pfizer Inc. common shareholders | $ | (0.29) | $ | 0.07 | * | $ | 1.37 | $ | 1.42 | (4) | ||||||||||
| Earnings (loss) per common share--diluted | ||||||||||||||||||||
| Income (loss) from continuing operations attributable to Pfizer Inc. common shareholders | $ | (0.29) | $ | 0.07 | * | $ | 1.36 | $ | 1.41 | (4) | ||||||||||
| Discontinued operations--net of tax | - | - | - | - | - | - | ||||||||||||||
| Net income (loss) attributable to Pfizer Inc. common shareholders | $ | (0.29) | $ | 0.07 | * | $ | 1.36 | $ | 1.41 | (3) | ||||||||||
| Weighted-average shares used to calculate earnings (loss) per common share | ||||||||||||||||||||
| Basic | 5,686 | 5,667 | 5,683 | 5,664 | ||||||||||||||||
| Diluted (8) | 5,686 | 5,703 | 5,713 | 5,700 |
*Indicates calculation not meaningful or results are greater than 100%.
PFIZER INC. AND SUBSIDIARY COMPANIES
NOTES TO CONSOLIDATED STATEMENTS OF OPERATIONS - (UNAUDITED)
(1)The financial statements present the three and twelve months ended December 31, 2025 and December 31, 2024. Subsidiaries operating outside the U.S. are included for the three and twelve months ended November 30, 2025 and November 30, 2024.
Business development activities, including the November 2025 acquisition of Metsera, Inc. (Metsera), impacted financial results in the periods presented. See Note 2 to the condensed consolidated financial statements and the Overview of Our Performance, Operating Environment, Strategy and Outlook-Our Business Development Initiatives and Other Recent Developments section of Management's Discussion and Analysis of Financial Condition and Results of Operations in Pfizer's Quarterly Report on Form 10-Q for the quarterly period ended September 28, 2025.