Full Press Release Details
PDS Biotechnology Announces Presentation of Universal Flu Vaccine Preclinical Data at the 41st American Society of Virology
PDS0202 neutralized multiple strains of influenza and provided protection against infection in preclinical studies
FLORHAM PARK, N.J., July 14, 2022 (GLOBE NEWSWIRE) -- PDS Biotechnology Corporation (Nasdaq: PDSB), a clinical-stage immunotherapy company developing
a growing pipeline of molecularly targeted cancer immunotherapies and infectious disease vaccines based on the Company's proprietary Versamune and Infectimune T cell activating technologies, today announced an upcoming poster
presentation at the 41st annual meeting of the American Society of Virology meeting. The study demonstrated that the investigational universal flu vaccine was effective against multiple strains of the influenza virus.
In this preclinical study, PDS0202, in which Infectimune is formulated with Computationally Optimized Broadly Reactive Antigens (COBRA) influenza
antigens developed by the laboratory of renowned influenza expert, Dr. Ted Ross, was evaluated for its potential ability to provide effective and broad neutralization of multiple influenza strains as well as to provide protection against infection.
"We are pleased to share the potential of the novel Infectimune and COBRA-based investigational vaccine with the virology community," said Lauren V. Wood, MD, Chief Medical Officer of PDS Biotech. "According to the
World Health Organization, influenza is estimated to result in about 3 to 5 million cases of severe illness, and about 290,000 to 650,000 respiratory deaths globally each year. Currently, there is no universal
vaccine that provides broad protection against multiple strains of influenza. As a result, the protective efficacy of the current vaccines varies widely from season to season. These data suggest that PDS0202 has the potential to achieve the goal of providing the broad protection sought in a universal influenza vaccine."
results show the potential of PDS0202 to be effective in preventing viral invasion of the lungs by multiple strains of the influenza virus," stated Ted Ross, Ph.D., Professor, and Director of the Center for
Vaccines and Immunology, University of Georgia. "The demonstration of a well characterized and robust immune response to the COBRA antigens suggests potential for broad and long-term protection against multiple strains of influenza."
The preclinical PDS0202 study was sponsored by the National Institute of Allergy and Infectious Diseases (NIAID) and was performed by Drs. Jerold
Woodward at the University of Kentucky College of Medicine and Ted Ross at the University of Georgia. Dr. Ted Ross is Principal Investigator at the NIAID Collaborative Influenza Vaccine Innovation Center (CIVICs) located at the University of
Georgia. PDS Biotech has licensed the COBRA antigens from the University of Georgia to develop PDS0202.
Abstract Number: 3733830
Program Number: P9-19
Abstract Title: Infectimune enhances antibodies elicited by COBRA hemagglutinin influenza vaccine
Presenting Author: Hua Shi, Center for Vaccines and Immunology, University of Georgia
Session: P9: Orthomyxoviruses
Date and Time: Sunday, July 17, 2022; 8:30 PM to 10:00 PM EDT
Location: Exhibit Hall B
About PDS Biotechnology
PDS Biotech is a clinical-stage immunotherapy company developing a growing pipeline of molecularly targeted cancer and infectious disease
immunotherapies based on the Company's proprietary Versamune and Infectimune T cell activating technology platforms. We believe our Versamune -based products have demonstrated the potential to overcome the limitations of
current immunotherapy by inducing in vivo, large quantities of high-quality, highly potent polyfunctional tumor specific CD4+ helper and CD8+ killer T cells. PDS Biotech has developed multiple therapies,
based on combinations of Versamune and disease-specific antigens, designed to train the immune system to better recognize diseased cells and effectively attack and destroy them. The Company continues to advance its pipeline of
preclinical and clinical candidates to address a wide range of cancers including HPV16-associated cancers (anal, cervical, head and neck, penile, vaginal, vulvar) and breast, colon, lung, prostate and ovarian cancers.
Our Infectimune -based vaccines have demonstrated the potential to induce not only
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operations and complete the development and commercialization of its product candidates, and the risks that raising such additional capital may restrict the Company's operations or require the Company to relinquish rights to the Company's
technologies or product candidates; the Company's limited operating history in the Company's current line of business, which makes it difficult to evaluate the Company's prospects, the Company's business plan or the likelihood of the Company's
successful implementation of such business plan; the timing for the Company or its partners to initiate the planned clinical trials for PDS0101, PDS0203 and other Versamune and Infectimune -based product candidates; the future success
of such trials; the successful implementation of the Company's research and development programs and collaborations, including any collaboration studies concerning PDS0101, PDS0203 and other Versamune and Infectimune -based product
candidates and the Company's interpretation of the results and findings of such programs and collaborations and whether such results are sufficient to support the future success of the Company's product candidates; the success, timing and cost of
the Company's ongoing clinical trials and anticipated clinical trials for the Company's current product candidates, including statements regarding the timing of initiation, pace of enrollment and completion of the trials (including the Company's
ability to fully fund its disclosed clinical trials, which assumes no material changes to our currently projected expenses), futility analyses, presentations at conferences and data reported in an abstract, and receipt of interim or preliminary
results (including, without limitation, any preclinical results or data), which are not necessarily indicative of the final results of the Company's ongoing clinical trials; any Company statements about its understanding of product candidates
mechanisms of action and interpretation of preclinical and early clinical results from its clinical development programs and any collaboration studies; and other factors, including legislative, regulatory, political and economic developments not
within the Company's control, including unforeseen circumstances or other disruptions to normal business operations arising from or related to COVID-19. The foregoing review of important factors that could cause actual events to differ from
expectations should not be construed as exhaustive and should be read in conjunction with statements that are included herein and elsewhere, including the risk factors included in the Company's annual and periodic reports filed with the SEC. The
forward-looking statements are made only as of the date of this press release and, except as required by applicable law, the Company undertakes no obligation to revise or update any forward-looking statement, or to make any other forward-looking
statements, whether as a result of new information, future events or otherwise.
Versamune is a registered trademark and Infectimune is a trademark of PDS Biotechnology.
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Email: pdsb@cg.capital