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Palisade Bio to Present at the Piper Sandler 37th Annual Healthcare Conference

Key Takeaway: Palisade Bio, Inc. announced their participation in the Piper Sandler 37th Annual Healthcare Conference, featuring a live webcast fireside chat with CEO JD Finley and CMO Dr. Mitchell Jones. The company is focusing on advancing PALI-2108, a new oral PDE4 inhibitor prodrug aimed at treating inflammatory and fibrotic diseases, particularly moderate-to-severe Ulcerative Colitis and Fibrostenotic Crohn’s Disease. Recent Phase 1b trial results showed encouraging outcomes for PALI-2108, prompting preparations for a Phase 2 clinical study to assess its effectiveness and safety further.
Price reaction · baseline $2.28 (2025-11-24 close) · hit after-hours · clean, no other PALI news in the window
day 0 close
-5.7%
day 1
-2.2%
day 3 · peak
-18%

Market Sentiment Analysis

POSITIVE FACTORS

  • Palisade Bio's lead program, PALI-2108, achieved a 100% clinical response in Ulcerative Colitis cohort.
  • Management engagement at the conference shows proactivity in investor relations and transparency.
  • Palisade Bio's focus on improving treatment options for chronic inflammatory and fibrotic diseases is promising.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Best trade, last catalyst
+50%
120-day peak, hindsight
Typical move
6.1%
average across 7 past catalysts
Cash runway
~49 mo
Minimal dilution risk
Lead asset
PALI-2108
Phase 1 · Fibrostenotic Crohn's Disease

Full Press Release Details

Live webcast fireside chat on Thursday, December 4th at 10:30 AM ET
Carlsbad, CA, Nov. 25, 2025 (GLOBE NEWSWIRE) -- Palisade Bio, Inc. (Nasdaq: PALI) (“Palisade” or the “Company”), a clinical-stage biopharmaceutical company advancing next-generation, once daily, oral PDE4 inhibitor prodrugs for patients with inflammatory and fibrotic diseases, today announced JD Finley, Chief Executive Officer and Dr. Mitchell Jones, Chief Medical Officer of Palisade Bio, will participate in a fireside chat at the Piper Sandler 37th Annual Healthcare Conference on Thursday, December 4, 2025 at 10:30 AM ET.
In addition to the fireside chat, management will be available to participate in one-on-one in-person meetings with qualified members of the investor community who are registered to attend the conference.
A live webcast of the fireside chat will be accessible on the Events page in the Investors section of the Company’s website (palisadebio.com). The webcast replay will be available two hours following the live event and will be archived for 90 days.
Palisade Bio, Inc. (Nasdaq: PALI) (“Palisade” or the “Company”) is a clinical-stage biopharmaceutical company advancing a next generation of, once daily, oral PDE4 inhibitor prodrugs designed to improve pharmacology, tolerability and convenience for patients with inflammatory and fibrotic diseases. Through its differentiated prodrug platform and precision pharmacology strategy, Palisade Bio is committed to transforming proven PDE4 biology into better, safer oral therapies for patients living with chronic inflammatory and fibrotic diseases.
The Company’s lead program, PALI-2108, is a locally-bioactivated PDE4 inhibitor prodrug being developed for moderate-to-severe Ulcerative Colitis (UC) and Fibrostenotic Crohn’s Disease (FSCD), two diseases with limited non-immunosuppressive therapy options. In a recently reported Phase 1b trial, PALI-2108 achieved a 100% clinical response in the UC cohort, with no serious adverse events, favorable tolerability and pharmacokinetics consistent with sustained localized activation, low systemic exposure, and controlled release within the GI tract.
Palisade Bio is now advancing towards a Phase 2 clinical study in UC designed to evaluate clinical remission, response and pharmacodynamic biomarkers over 12 weeks, with an extension phase assessing maintenance of remission. In addition, the Company is preparing to initiate studies in FSCD to further characterize PALI-2108’s safety, pharmacology and therapeutic benefit across inflammatory bowel disease indications. For more information, please go to www.palisadebio.com.
Investor Relations Contact
Source: Palisade Bio

Frequently Asked Questions

When is the fireside chat scheduled?

The fireside chat will take place on December 4, 2025, at 10:30 AM ET.

Who will participate in the fireside chat?

JD Finley and Dr. Mitchell Jones from Palisade Bio will participate.

Where can I access the live webcast?

The live webcast can be found on the Events page in the Investors section of the website.

What is PALI-2108 being developed for?

PALI-2108 is being developed for moderate-to-severe Ulcerative Colitis and Fibrostenotic Crohn's Disease.

What is unique about Palisade's PDE4 inhibitors?

They are designed to improve pharmacology, tolerability, and convenience for patients.

Last updated: Nov 25, 2025