Deanne Eagle - Media Relations 917.837.5866 Susan Roush - Investor Relations 818.222.8330

NEURALSTEM REPORTS SECOND QUARTER FINANCIAL

PROVIDES CLINICAL PROGRAM AND BUSINESS HIGHLIGHTS

Maryland, August 10, 2012 - Neuralstem, Inc. (NYSE MKT: CUR) reported its financial results for the three months and six

months ended June 30, 2012 and provided clinical program and business highlights.

"The Company continued to make progress

in our ongoing ALS cell therapy clinical trial in the second quarter of 2012," said Karl Johe, PhD, Chairman of Neuralstem's

Board of Directors and Chief Scientific Officer. "With FDA approval, we are currently transplanting a cohort of return patients

that had previously received lumbar injections. Patients 16 and 17 have now received cervical injections."

Dr. Johe continued, "The second quarter

also saw the Phase Ib commencement of the ongoing trial of our lead neurogenic small molecule compound, NSI-189, for the treatment

of major depressive disorder (MDD). Phase Ib tests the safety of escalating doses for a 28-day cycle."

Neuralstem's President and CEO, Richard

Garr, added, "During the quarter, we increased the total number of owned or exclusively licensed worldwide issued patents

to 27. We continue to expand our intellectual property in the field of regenerative medicine with an additional 44 pending U.S.

and foreign patent applications related to our stem cell technologies and our small molecule compounds.

"Dr. Johe and I would like to thank

the ALS cell therapy investigators: University of Michigan's Dr. Eva Feldman and Emory University's Dr. Jonathan Glass

and Dr. Nicolas Boulis, and Harvard's Dr. Maurizio Fava who helped to design the NSI-189/MDD trial. We continue to thank

our courageous patients and their families," concluded Garr.

and Business Highlights

NSI-566 Phase I Clinical Trial in ALS (amyotrophic lateral sclerosis, or Lou Gehrig's disease) at Emory University Hospital

returning patient 16 received five injections in the cervical region, in addition to the ten he received previously in the lumbar

region of the spine, for a total of 15 injections.

- In June, the Emory University Institutional

Review Board approved the FDA-approved amendment to the trial protocol, permitting the return of three previously treated patients

to the trial to receive additional dosing.

the FDA approved additional dosing of three patients from earlier cohorts for second treatments as the next, final cohort of patients,

provided they met requirements at the scheduled time.

Small Molecule NSI-189: Phase I Clinical Trial in Major Depressive Disorder (MDD)

- In June, the first patient was dosed

in the Phase Ib stage of the ongoing NSI-189/MDD trial. This phase tests the safety of NSI-189 for 28 daily administrations in

24 patients with MDD.

- Subsequent Event: In July, the company

extended the employment contracts of Dr. Karl Johe, Richard Garr, and Dr. Thomas Hazel for an additional 60 months.

For the second quarter of 2012, the Company

reported a net loss of $2,376,381 or $0.04 per share, compared with a net loss of $3,648,725 or $0.08 per share, for the comparable

2011 period. The decrease in net loss was primarily due to a reduction in non-cash stock based compensation expense of approximately

$730,000 coupled with decreases in employee bonuses and legal expenses and revenue recognized in the second quarter of 2012.

For the six months ended June 30, 2012

the Company reported a net loss of $4,829,162 or $0.09 per share, compared with a net loss of $6,750,527, or $0.14 per share for

the comparable 2011 period. The decrease in net loss was primarily due to a reduction in non-cash stock based compensation

expense of approximately $1,500,000 coupled with decreases in employee bonuses and legal expenses and revenue recognized in 2012

partially offset by gains in 2011 of approximately $250,000 related to a legal settlement and $162,000 related to the changes in

the fair value of certain warrant obligations.

Cash and cash equivalents on hand at June

30, 2012 totaled $2,539,534, compared with $2,352,013 at December 31, 2011. The approximately $187,000 increase in cash and cash

equivalents over the six months of 2012 was primarily due to approximately $4,900,000 of net proceeds from a registered direct

financing in February 2012 largely offset by cash used in operations.

Neuralstem's patented technology enables

the ability to produce neural stem cells of the human brain and spinal cord in commercial quantities, and the ability to control

the differentiation of these cells constitutively into mature, physiologically relevant human neurons and glia. Neuralstem is in

an FDA-approved Phase I safety clinical trial for amyotrophic lateral sclerosis (ALS), often referred to as Lou Gehrig's disease,

and has been awarded orphan status designation by the FDA.

In addition to ALS, the company is also

targeting major central nervous system conditions with its cell therapy platform, including spinal cord injury, ischemic spastic

paraplegia and chronic stroke. The company has submitted an IND (Investigational New Drug) application to the FDA for a Phase I

safety trial in chronic spinal cord injury.

Neuralstem also has the ability to generate

stable human neural stem cell lines suitable for the systematic screening of large chemical libraries. Through this proprietary

screening technology, Neuralstem has discovered and patented compounds that may stimulate the brain's capacity to generate new

neurons, possibly reversing the pathologies of some central nervous system conditions. The company is in a Phase Ib safety

trial evaluating NSI-189, its first neurogenic small molecule compound, for the treatment of major depressive disorder (MDD). Additional

indications could include chronic traumatic encephalopathy (CTE), Alzheimer's disease, and post-traumatic stress disorder (PTSD).

For more information, please visit www.neuralstem.com

or connect with us on Twitter and Facebook.

Cautionary Statement Regarding Forward

This news release may contain forward-looking

statements made pursuant to the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. Investors

are cautioned that such forward-looking statements in this press release regarding potential applications of Neuralstem's technologies

constitute forward-looking statements that involve risks and uncertainties, including, without limitation, risks inherent in the

development and commercialization of potential products, uncertainty of clinical trial results or regulatory approvals or clearances,

need for future capital, dependence upon collaborators and maintenance of our intellectual property rights. Actual results may

differ materially from the results anticipated in these forward-looking statements. Additional information on potential factors

that could affect our results and other risks and uncertainties are detailed from time to time in Neuralstem's periodic reports,

including the annual report on Form 10-K for the year ended December 31, 2011 and the quarterly report on Form 10-Q for the period

ended June 30, 2012.