Certain confidential information contained in this document, marked by brackets, is omitted because it is not material and would be competitively harmful if publicly disclosed. IN WITNESS WHEREOF , this Amendment is here

[***] = Certain confidential information contained in this document, marked by brackets, is omitted because it is not material and would be competitively harmful if publicly disclosed.

THIS FIRST AMENDMENT TO LICENSE AGREEMENT (this "Amendment") is made as of this 10th day of May, 2019 ("Amendment Effective Date"), by and between Ovid Therapeutics Inc., with offices located at 1460 Broadway, Suite 15021, New York, NY 10036 ("Ovid"), and H. Lundbeck A/S, having a place of business located at Ottiliavej 9, DK 2500 Valby, Denmark ("Lundbeck").

WHEREAS, Ovid and Lundbeck previously entered into a certain License Agreement, dated as of March 25, 2015 relating to Gaboxadol (the "Agreement"), with capitalized terms used herein, if not otherwise defined, having the same meaning ascribed to them as in the Agreement; and

WHEREAS, Ovid and Lundbeck desire to amend certain term of the Agreement;

NOW, THEREFORE, in exchange for mutual consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto agree as follows:

1.1The title heading between Sections 2.3 and 2.4, "Right of First Negotiation" shall be amended to remove the title heading and Sections 2.4, 2.5, 2.6, 2.7 and 2.8 are hereby deleted in their entirety, removing the obligation for the Right of First Negotiation.

1.2Sections 4.2, and 4.3 Development Milestones. Sections 4.2 and 4.3 of the Agreement are hereby amended, and restated as follows:

1.3Section 4.5 and 4.6 Regulatory Milestones. Sections 4.5 and 4.6 of the Agreement shall be amended and restated as follows:

1.4Sections 4.9 and 4.10. Sales Milestones. Sections 4.9 and 4.10 of the Agreement shall be amended and restated as follows:

1.5The title heading between Sections 4.12 and 4.13, "Royalties Outside of Asian Markets" shall be amended and restated as follows, "Royalties".

1.6Sections 4.13, 4.14, 4.15, 4.16 and 4.17. Sections 4.13, 4.14, 4.15, 4.16 and 4.17 of the Agreement shall be amended and restated as follows:

Annual Net Sales Royalty Percentage

The portion of Net Sales for all Products in a Calendar [*]%

Year up to and including [*]

The portion of Net Sales for all Products in a Calendar [*]%

Year including or exceeding [*] but less

Than or equal to [*]

The portion of Net Sales for all Products in a Calendar [*]%

Year including or exceeding [*]

4.14Intentionally Omitted.

4.15 Intentionally Omitted.

4.16 Intentionally Omitted.

4.17 Intentionally Omitted.

All references to Sections 4.14, 4.15, 4.16 and 4.17 elsewhere in the Agreement shall be considered void and deleted.

1.7Section 4.19. Section 4.19 of the Agreement shall be amended and restated as follows:

2.1General. Other than the provision contained in this Amendment, the terms of the Agreement shall remain in full force and effect. This Amendment sets forth the entire agreement with respect to the foregoing, and taken together with the Agreement, constitutes the entire understanding of the parties with respect to the subject matter hereof.

2.2Counterparts. This Amendment may be executed in multiple counterparts, each of which shall be considered an original, and all of which, when taken together, shall constitute one and the same document.

[Signature Page Follows]

[***] = Certain confidential information contained in this document, marked by brackets, is omitted because it is not material and would be competitively harmful if publicly disclosed.

IN WITNESS WHEREOF, this Amendment is hereby entered into and agreed to by the parties as of the execution date first written above.

OVID THERAPEUTICS INC.

By: /s/ Thomas M. Perone

Name: Thomas M. Perone

Title: General Counsel

By: /s/ Deborah Dunsire

Name: Deborah Dunsire

By: /s/ Keld J rgensen

Name: Keld J rgensen