AMENDMENT NO. 3 TO EMPLOYMENT AGREEMENT This Amendment No. 3 to Employment Agreement entered into as of

AMENDMENT NO. 3 TO EMPLOYMENT AGREEMENT

This Amendment No. 3 to Employment Agreement entered into as of March 27, 2015 (this Amendment ), between Douglas A.

Michels ( Employee ) and OraSure Technologies, Inc., a Delaware corporation (the Company ).

WHEREAS, the parties

have previously entered into an Employment Agreement, dated as of June 22, 2004 as amended (the Original Agreement ), and desire to amend the Original Agreement as more fully set forth herein.

NOW, THEREFORE, intending to be legally bound, the parties hereby agree as follows:

6.4 Termination by Employee With Good Reason. Employee may terminate his employment under this Agreement for Good Reason; provided

that (i) Employee gives written notice to the Board of Directors within 90 days of the event constituting Good Reason; (ii) the Company has not cured the event giving rise to such notice within 30 days of receipt of Employee s notice;

and (iii) such termination of employment occurs not less than two years after the occurrence of the event constituting Good Reason. The term Good Reason shall mean any of the following: (a) a material breach of this Agreement

by the Company (or its successor); (b) a material diminution in Employee s base compensation or authority, duties or responsibilities, it being understood that, following a Change of Control, such a material diminution shall be deemed to

have occurred if Employee no longer is appointed or ceases to function as the sole chief executive officer of the successor organization; (c) a material diminution in the authority, duties or responsibilities of the person to whom Employee

reports, including a change in Employee s reporting obligation from the Board of Directors to another employee of the Company, it being understood that, following a Change of Control, such a material diminution shall be deemed to have occurred

if Employee no longer reports to a board of directors of a public company; (d) a material diminution of the budget over which Employee exercises control; or (e) a material change in Employee s job location.

6.7.2 Termination Without Cause or Upon Good Reason. In the event of a termination of Employee s employment with the Company

pursuant to Section 6.4 or 6.5, Employee: (i) shall be paid all salary pursuant to Section 3.1 through the date of termination and any bonus that has been approved by the Board of Directors or Compensation Committee prior to the date

of termination but not yet paid; (ii) shall (A) if such termination is for Good Reason pursuant to Section 6.4 or without Cause pursuant to Section 6.5 and does not occur during a Change of Control Period, be paid a lump sum

equivalent to 12 months of Employee s annual salary, or (B) if such termination is for Good Reason pursuant to Section 6.4 or without Cause pursuant to Section 6.5 and occurs during a Change of Control Period, be paid a

lump sum equivalent to 36 months of the Employee s annual salary; (iii) shall receive a cash bonus for the calendar year in which termination occurs equal to Employee s target bonus for such year established pursuant to

Section 3.2; and (iv) for a period of one year after the date of termination, shall receive benefits for Employee and/or Employee s family at levels substantially equal to those which would have been provided to them in accordance

with the plans described in Section 3.4 of this Agreement if Employee s employment had not been terminated, including health, disability and life insurance, in accordance with the most favorable plans of the Company in effect during the

90-day period immediately preceding the date of termination (amounts payable under clauses (ii), (iii) and (iv) are collectively referred to as severance ). Subject to Section 6.9, all payments will be made (or commence)

under this Section 6.7 on the 90th day after termination of employment hereunder.

As a condition to receipt of severance under this

Section 6.7.2, within 30 days following termination of Employee s employment, Employee shall sign and deliver a release agreement, in form and substance substantially as set forth in Exhibit C hereto, releasing all claims related to

Employee s employment. The severance shall be in lieu of and not in addition to any other severance arrangement maintained by the Company, and shall be offset by any monies Employee may owe to the Company. The Company s obligation to pay

the amounts stated in clauses (ii), (iii) and (iv) of this Section 6.7.2 shall terminate if, during the period commencing on termination of employment and continuing until all severance payments have been made by the Company, Employee

fails to comply with the Confidentiality Agreement and such failure would constitute a material breach of this Agreement under Section 5 hereof.

The parties have executed this Amendment as of the date indicated above.