ASX, Nasdaq and Media Release 10 November 2022 Opthea to Present at Jefferies London Healthcare Conference Melbourne, Australia; 10 November, 2022 Opthea Limited (NASDAQ:OPT; ASX:OPT), a clinical stage biopharmaceutical

ASX, Nasdaq and Media Release

Opthea to Present at Jefferies London

Healthcare Conference

Melbourne, Australia; 10 November, 2022 Opthea Limited (NASDAQ:OPT; ASX:OPT), a clinical stage biopharmaceutical

company developing novel therapies to treat highly prevalent and progressive retinal diseases, today announced that Chief Executive Officer Dr. Megan Baldwin will present at the Jefferies London Healthcare Conference on Tuesday,

November 15, 2022 at 7:25 AM GMT (6:25 PM AEDT).

The live audio will be webcast and may be accessed for 90 days on the Investors page of the

Opthea website at https://www.opthea.com/presentations/.

About Opthea Limited

Opthea (ASX:OPT; Nasdaq:OPT) is a biopharmaceutical company developing novel therapies to address the unmet need in the treatment of highly prevalent and

progressive retinal diseases, including wet age-related macular degeneration (wet AMD) and diabetic macular edema (DME). Opthea s lead product candidate OPT-302 is

in pivotal Phase 3 clinical trials and being developed for use in combination with anti-VEGF-A monotherapies to achieve broader inhibition of the VEGF family, with the goal of improving overall efficacy and

demonstrating superior vision gains over that which can be achieved by inhibiting VEGF-A alone.

of Investment in Biotechnology Companies

There are a number of inherent risks associated with the development of pharmaceutical products to a

marketable stage. The lengthy clinical trial process is designed to assess the safety and efficacy of a drug prior to commercialization and a significant proportion of drugs fail one or both of these criteria. Other risks include uncertainty of

patent protection and proprietary rights, whether patent applications and issued patents will offer adequate protection to enable product development, the obtaining of necessary drug regulatory authority approvals and difficulties caused by the

rapid advancements in technology. Companies such as Opthea are dependent on the success of their research and development projects and on the ability to attract funding to support these activities. Investment in research and development projects

cannot be assessed on the same fundamentals as trading and manufacturing enterprises. Therefore, investment in companies specializing in drug development must be regarded as highly speculative. Opthea strongly recommends that professional investment

advice be sought prior to such investments.

Authorized for release to ASX by Megan Baldwin, CEO & Managing Director

Company & Media Enquiries:

NorthStream Global Partners

Join our email database

to receive program updates:

Tel: +61 (0) 3 9826 0399 Email: info@opthea.com Web: www.opthea.com