TO CREDIT AGREEMENT (this "Amendment") is made and entered into as of December 23, 2013, by and among BIOSCRIP,

THIS FIRST AMENDMENT

TO CREDIT AGREEMENT (this "Amendment") is made and entered into as of December 23, 2013, by and among BIOSCRIP,

INC., a Delaware corporation (the "Borrower"), each of the Subsidiaries of the Borrower identified on the signature

pages hereto as a "Guarantor" (each, a "Guarantor" and, collectively, the "Guarantors";

the Borrower and the Guarantors, each, a "Loan Party" and, collectively, the "Loan Parties"),

the Lenders party hereto, and SUNTRUST BANK, in its capacity as administrative agent for itself and the Lenders (the "Administrative

WHEREAS, the Borrower,

the banks and other financial institutions and lenders party thereto (collectively, the "Lenders"), and the

Administrative Agent have executed and delivered that certain Credit Agreement dated as of July 31, 2013 (as amended, restated,

supplemented, or otherwise modified from time to time, the "Credit Agreement"); and

WHEREAS, the Borrower

has requested that the Administrative Agent and the Lenders agree to amend certain other provisions of the Credit Agreement as

set forth herein, and the Administrative Agent and the Lenders party hereto have agreed to such extension and amendments, in each

case, subject to the terms and conditions set forth below.

and in consideration of the above premises and other good and valuable consideration, the receipt and sufficiency of which is hereby

acknowledged by the parties hereto, the parties hereto hereby covenant and agree as follows:

SECTION 1. Definitions.

Unless otherwise specifically defined herein, each term used herein (and in the recitals above) which is defined in the Credit

Agreement (as amended hereby) shall have the meaning assigned to such term in the Credit Agreement (as amended hereby). Each reference

to "hereof," "hereunder," "herein," and "hereby" and each other similar reference

and each reference to "the Agreement" and each other similar reference contained in the Credit Agreement shall from

and after the date hereof refer to the Credit Agreement as amended hereby.

SECTION 2. Amendments

to Credit Agreement. The Credit Agreement is hereby amended as follows:

1.1 of the Credit Agreement is hereby amended by adding the following new defined term thereto in appropriate alphabetical

Settlement" shall mean the Borrower's payment of an amount equal to $15,000,000, together with applicable interest

thereon (plus any amounts arising out of the Borrower's obligation to reimburse certain parties for their out of pocket expenses)

to settle certain allegations relating to the prescription drug known as Exjade as described in the Borrower's Form 8-K filed

with the SEC on or about December 16, 2013.

4.21(f) of the Credit Agreement is hereby amended so that it reads in its entirety as follows:

December 31, 2012, none of the Borrower nor any of its Subsidiaries, nor, to the knowledge of the Borrower, any employee or contractor

of the Borrower or any of its Subsidiaries has been, or to the knowledge of the Borrower has been threatened to be, (i) excluded

from any Governmental Payor Arrangement pursuant to 42 U.S.C. 1320a-7b and related regulations, (ii) "suspended"

or "debarred" from selling products to the U.S. government or its agencies pursuant to the Federal Acquisition Regulation,

relating to debarment and suspension applicable to federal government agencies generally (42 C.F.R. Subpart 9.4), or other applicable

laws or regulations, (iii) debarred, disqualified, suspended or excluded from participation in Medicare, Medicaid or any other

governmental health care program or is listed on the General Services Administration list of excluded parties, nor is any such

debarment, disqualification, suspension or exclusion, to the knowledge of a Loan Party, threatened or pending, or (iv) made a party

to any other action by any Governmental Authority that may prohibit it from selling products or providing services to any governmental

or other purchaser pursuant to any federal, state or local laws or regulations. Except for the payment of the amounts expressly

provided for in the Exjade Settlement, none of the Borrower nor any of its Subsidiaries, nor, to the knowledge of the Borrower,

any employee or contractor of the Borrower or any of its Subsidiaries is party to a corporate integrity agreement, consent order,

consent decree, permanent injunction or other settlement agreement with any Governmental Authority or Third Party Payor or otherwise

pursuant to any Governmental Payor Arrangement, Third Party Payor Arrangement, License, or Company Accreditation, including, without

limitation, any additional corporate integrity agreement, consent order, consent decree, permanent injunction or other settlement

agreement arising out of allegations involving the Borrower and the prescription drug known as Exjade, which individually (or,

together with any related Settlements (other than the Exjade Settlement), in the aggregate) (i) would reasonably be expected to

result in a Material Adverse Effect or (ii) requires the payment of money in an amount in excess of $12,500,000.

8.1(k) of the Credit Agreement is hereby amended so that it reads in its entirety as follows:

final non-consensual judgment or order for the payment of money (to the extent not covered by insurance as to which the insurer

has been notified of such judgment and has not denied coverage in writing) in excess of $12,500,000 individually (or, together

with any related non-consensual judgment or order, in the aggregate) shall be rendered against the Borrower or any of its Subsidiaries,

and either (i) enforcement proceedings shall have been commenced by any creditor upon such non-consensual judgment or order or

(ii) such non-consensual judgment or order remains unvacated, unbounded or unstayed for a period of 30 consecutive days; or

SECTION 3. Representations

and Warranties. Each Loan Party hereby represents and warrants to the Administrative Agent and the Lenders as follows:

(a) Both immediately

before and immediately after giving effect to this Amendment, all representations and warranties of each Loan Party set forth in

the Loan Documents are true and correct in all material respects (other than those representations and warranties (i) that are

expressly qualified by a Material Adverse Effect or other materiality, in which case such representations and warranties are true

and correct in all respects or (ii) that expressly relate to an earlier date, in which case such representations and warranties

are true and correct in all material respect as of such earlier date).

or Event of Default has occurred and is continuing or would result from giving effect to the terms hereof.

delivery and performance by each Loan Party of this Amendment are within such Loan Party's organizational powers and have

been duly authorized by all necessary organizational and, if required, shareholder, partner or member action.

has been duly executed and delivered by each Loan Party and constitutes valid and binding obligations of such Loan Party, enforceable

against it in accordance with its terms, except as may be limited by applicable bankruptcy, insolvency, reorganization, moratorium

or similar laws affecting the enforcement of creditors' rights generally and by general principles of equity.

SECTION 4. Conditions

Precedent. This Amendment shall become effective only upon satisfaction of the following conditions precedent:

and delivery of this Amendment by each Loan Party, the Administrative Agent and each of the Required Lenders;

shall have paid to the Administrative Agent, for the benefit of each Lender who has executed this Amendment prior to 5:00 pm (Atlanta,

Georgia time) on December 20, 2013, an amendment fee equal to 0.10% of the outstanding aggregate amount of Revolving Commitments

and Term Loans of such Lender as of the date thereof; and

shall have paid all other costs, fees, and expenses owed by the Borrower to the Administrative Agent, including, without limitation,

reasonable attorneys' fees and expenses.

SECTION 5. Miscellaneous

For avoidance of doubt, the Borrower, the Lenders party hereto, and the Administrative Agent hereby acknowledge and agree that

this Amendment is a Loan Document.

Amendment. Except as set forth expressly hereinabove, all terms of the Credit Agreement and the other Loan Documents shall

be and remain in full force and effect, and shall constitute the legal and binding obligation of the Borrower, enforceable against

such Borrower Party in accordance with their respective terms. Except to the extent otherwise expressly set forth herein, the amendments

set forth herein shall have prospective application only from and after the date of this Amendment.

or Mutual Departure. The Loan Parties expressly acknowledge and agree that (i) there has not been, and this Amendment does

not constitute or establish, a novation with respect to the Credit Agreement or any of the other Loan Documents, or a mutual departure

from the strict terms, provisions, and conditions thereof, other than with respect to the amendments contained in Section 2

above and (ii) nothing in this Amendment shall affect or limit the Administrative Agent's or any Lender's right to

demand payment of liabilities owing from any Loan Party to the Administrative Agent or any Lender under, or to demand strict performance

of the terms, provisions, and conditions of, the Credit Agreement and the other Loan Documents, to exercise any and all rights,

powers, and remedies under the Credit Agreement or the other Loan Documents or at law or in equity, or to do any and all of the

foregoing, immediately at any time after the occurrence of a Default or an Event of Default under the Credit Agreement or the other

The Borrower hereby restates, ratifies, and reaffirms each and every term, covenant, and condition set forth in the Credit Agreement

and the other Loan Documents to which it is a party (as such terms, covenants, and conditions are amended by Section 2 above)

effective as of the date hereof.

To induce the Administrative Agent and the Lenders to enter into this Amendment and to continue to make advances pursuant to the

Credit Agreement (subject to the terms and conditions thereof), each Loan Party hereby acknowledges and agrees that, as of the

date hereof, and after giving effect to the terms hereof, there exists no right of offset, defense, counterclaim, claim, or objection

in favor of any Loan Party or arising out of or with respect to any of the Loans or other obligations of any Loan Party owed to

the Administrative Agent or any Lender under the Credit Agreement or any other Loan Document.

This Amendment may be executed in any number of counterparts and by the parties hereto in separate counterparts, each of which