BeOne Medicines Expands U.S. Manufacturing with Total Investment of More Than $1 Billion to Advance Innovative Cancer Medicines

$300 millionexpansion of flagship manufacturing facility inHopewell, New Jersey, adds small molecule manufacturing capacity, enhancingU.S. domestic production capabilities

Creates 120 new full-time jobs to supportU.S. manufacturing of BeOne's innovative oncology medicines and deep clinical pipeline

SAN CARLOS, Calif.--(BUSINESS WIRE)--BeOne Medicines, Ltd. (Nasdaq: ONC; HKEX: 06160; SSE: 688235), a global oncology company, today announced a$300 millionexpansion of its flagship clinical and commercial-stage manufacturing and research and development center at the Princeton West Innovation Campus inHopewell, New Jersey, bringing totalU.S. manufacturing investment to more than$1 billion. The expansion will increase BeOne's production capacity to manufacture its medicines and is expected to create approximately 120 new full-time jobs. The investment supports the continued advancement of BeOne's deep oncology pipeline of more than 35 clinical and commercial-stage assets.

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BeOne Medicines'biologics manufacturing facility and clinical R&D center of excellence at the Princeton West Innovation Campus inHopewell, NJ.

Aaron Rosenberg, Chief Financial Officer,BeOne Medicines, said:“Today's announcement reflects BeOne's commitment to strengtheningU.S. manufacturing and expanding access to innovative medicines for patients with cancer. We appreciate the federal tax policies advanced by the President that encourage investment in biopharmaceutical production, alongside the Next New Jersey Manufacturing Program and the Governor’s efforts to support advanced manufacturing and high-quality job creation. Together, these efforts create an environment for long-term growth, and we are proud to continue expanding our global footprint in support of patients.”

Expanding manufacturing capacityWith this expansion, BeOne's Princeton West Innovation Campus will become a fully integrated, multi-platform manufacturing site, combining existing biologics production with new small molecule drug product capabilities under one roof. The expansion involves construction of a new three-story, 145,000-square-foot building adjacent to BeOne's existingHopewellfacilities, bringing the total campus footprint to approximately 545,000 square feet. The new building will house drug product manufacturing and packaging operations that strengthen BeOne's production and supply chain capabilities to support its growing hematology portfolio and pipeline, alongside quality control laboratories, office space, and capacity reserved for future growth. The expanded site will also provide additional flexibility to support strategic collaborations with partners and advance BeOne's global development superhighway.

• Total capital investment:$300 million, bringing totalHopewellinvestment to more than$1 billion

• New full-time positions:Approximately 120

• New construction:Approximately 145,000 square feet; expanded facility anticipated to be fully operational in 2029

• Total campus size post-expansion:Approximately 545,000 square feet

• Hopewellsite headcount:Approximately 240 by the end of 2029

BeOne's Princeton West Innovation CampusOpened inJuly 2024following an initial investment of$800 million, the latest$300 millionexpansion brings total investment at the Princeton West Innovation Campus to more than$1 billion. As BeOne's flagshipU.S. manufacturing and clinical R&D hub, the campus also supports clinical and commercial-stage biologics manufacturing for the Company's solid tumor portfolio. The 42-acre site features more than 1 million square feet of developable real estate for future growth.

Accelerating BeOne's global development superhighwayTheU.S. expansion strengthens BeOne’s global development superhighway, the company’s fully internal platform of clinical, regulatory, and manufacturing capabilities. This strategically advantaged model combines one of the industry’s largest oncology research teams with nearly 6,000 clinical development and manufacturing colleagues, helping reduce the cost and time required to develop new medicines for cancer patients around the world. The added capacity will support pipeline programs across multiple blood cancers, as well as breast, gynecologic, lung, liver, gastrointestinal, and other tumor types. These programs span multiple innovative modalities, including small molecules, biologics, targeted protein degraders, multispecific antibodies, and antibody drug conjugates.

BeOne inthe United StatesBeOne is domiciled inSwitzerlandand employs over 12,000 colleagues across six continents, including more than 2,000 in theU.S. In 2025, BeOne generated nearly$2 billionin directU.S. economic impact and invested approximately$1 billioninU.S. R&D. The company is conducting 93 clinical trials across 45 states and one territory at approximately 1,100 clinical trial sites, supported by more than 650 investigators.BeOne Medicineshas delivered its life-changing cancer therapies to more than 2 million patients globally.

About BeOneBeOne Medicines is a global oncology company that is discovering and developing innovative treatments for cancer patients worldwide. With a portfolio spanning hematology and solid tumors, BeOne is expediting development of its diverse pipeline of novel therapeutics through its internal capabilities and collaborations. The company has a growing global team spanning six continents who are driven by scientific excellence and exceptional speed to reach more patients than ever before. To learn more about BeOne, please visitwww.beonemedicines.comand follow us onLinkedIn,X,FacebookandInstagram.

Forward-Looking StatementThis press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 and other federal securities laws, including statements regarding the potential effects of BeOne’s expansion of its flagship manufacturing facility in Hopewell, New Jersey; the increase of BeOne’s production capacity to manufacture its medicines in the U.S.; the continued advancement of BeOne’s deep oncology pipeline; the additional flexibility to support BeOne’s strategic collaborations with partners and advance BeOne’s global development superhighway; and BeOne’s plans, commitments, aspirations, and goals under the heading “About BeOne.” Actual results may differ materially from those indicated in the forward-looking statements as a result of various important factors, including BeOne’s ability to demonstrate the efficacy and safety of its drug candidates; the clinical results for its drug candidates, which may not support further development or marketing approval; actions of regulatory agencies, which may affect the initiation, timing, and progress of clinical trials and marketing approval; BeOne’s ability to achieve commercial success for its marketed medicines and drug candidates, if approved; BeOne’s ability to obtain and maintain protection of intellectual property for its medicines and technology; BeOne’s reliance on third parties to conduct drug development, manufacturing, commercialization, and other services; BeOne’s limited experience in obtaining regulatory approvals and commercializing pharmaceutical products and its ability to obtain additional funding for operations and to complete the development of its drug candidates and achieve and maintain profitability; and those risks more fully discussed in the section entitled “Risk Factors” in BeOne’s most recent quarterly report on Form 10-Q, as well as discussions of potential risks, uncertainties, and other important factors in BeOne’s subsequent filings with the U.S. Securities and Exchange Commission. All information in this press release is as of the date of this press release, and BeOne undertakes no duty to update such information unless required by law.

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Source: BeOne Medicines Ltd.