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OKYO Pharma Announces Director Acquires Shares

Key Takeaway: OKYO Pharma Limited announced that Non-Executive Director John Brancaccio has acquired an additional 5,000 shares in the company, raising his total holdings to 31,201 shares. The biopharmaceutical firm is advancing its investigational therapy, urcosimod, which has shown promise in reducing pain in neuropathic corneal pain patients in recent clinical trials. The company has plans to begin a larger Phase 2b/3 trial later this year, reflecting its ongoing commitment to developing treatments for inflammatory eye diseases.
Price reaction · baseline $1.62 (2026-03-18 close) · hit after-hours · 1 other OKYO headline(s) in the window, move may be shared
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Market Sentiment Analysis

POSITIVE FACTORS

  • John Brancaccio, a director, is increasing his stake in the company, indicating confidence in OKYO's future.
  • Positive results from a randomized Phase 2a trial for neuropathic corneal pain suggest effective treatment potential.
  • The company plans to initiate a Phase 2b/3 multiple-dose study for urcosimod, indicating ongoing commitment to development.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Best trade, last catalyst
+13%
120-day peak, hindsight
Typical move
9%
average across 7 past catalysts
Lead asset
OK-101
Phase 2 · Dry Eye Disease

Full Press Release Details

LONDON and NEW YORK, March 19, 2026 (GLOBE NEWSWIRE) -- OKYO Pharma Limited (NASDAQ: OKYO), a clinical-stage biopharmaceutical company developing investigational therapies for the treatment of neuropathic corneal pain (NCP) and for inflammatory eye diseases, today announced it has been informed that John Brancaccio, Non-Executive Director, has acquired 5,000 of the Company’s ordinary shares on NASDAQ at $1.61, bringing his total holding to 31,201 shares.
About Urcosimod (formerly called OK-101)
Urcosimod is a lipid conjugated chemerin peptide agonist of the ChemR23 G-protein coupled receptor which is typically found on immune cells of the eye responsible for the inflammatory response, as well as on neurons and glial cells in the dorsal root ganglion. Urcosimod has been shown to produce anti-inflammatory and pain-reducing activities in a mouse model of dry eye disease and in a neuropathic corneal pain mouse model, respectively. OKYO recently announced positive data on NCP pain reduction in a randomized, placebo-controlled, double-masked Phase 2a trial involving 18 neuropathic corneal pain subjects. Urcosimod has shown significant pain reduction in an earlier 240 subject Phase 2, multi-center, double-masked, placebo-controlled trial in DED, which supports the development rationale in NCP.
OKYO Pharma Limited (Nasdaq: OKYO) is a clinical-stage biopharmaceutical company developing innovative therapies for the treatment of neuropathic corneal pain (NCP) and inflammatory eye diseases, with ordinary shares listed for trading on the Nasdaq Capital Market. OKYO is focused on the discovery and development of novel molecules to treat neuropathic corneal pain and other ocular diseases. OKYO recently completed a successful phase 2 trial of its flagship drug urcosimod in subjects with NCP and plans to initiate a ~150 subject Phase 2b/3 multiple-dose study of urcosimod to treat NCP in the first half of this year.
For further information, please visit www.okyopharma.com.

Frequently Asked Questions

What is Urcosimod used for?

Urcosimod is developed to treat neuropathic corneal pain and inflammatory eye diseases.

Who is John Brancaccio?

John Brancaccio is a Non-Executive Director at OKYO Pharma Limited.

What type of trials has Urcosimod undergone?

Urcosimod has completed Phase 2 trials for neuropathic corneal pain and dry eye disease.

Where can I find more information on OKYO Pharma?

More information is available at www.okyopharma.com.

Last updated: Mar 19, 2026