Oragenics, Inc. Preparing for Phase II Clinical Trials to Treat Concussion

Inc. Preparing for Phase II Clinical Trials to Treat Concussion

Fla.-(BUSINESS WIRE)-Oragenics, Inc. (NYSE American: OGEN), a company focused on developing unique, intranasal nanoparticle

pharmaceuticals for the treatment of neurological disorders, today announced it is preparing for a Phase II clinical trial using its

novel drug - device combination for the treatment of mild Traumatic Brain Injury, aka concussion. Oragenics' lead drug candidate,

ONP-002, is a new chemical entity (NCE) designed to target the brain through self-propelled powdered delivery into the nasal cavity.

A 40-patient Phase I study showed ONP-002 to be safe and well-tolerated.

has begun the final process of synthesizing and formulating the drug needed for its Phase II clinical trial. It is expected that enrolled

patients will be in the acute phase following concussions, after diagnosis the patient will quickly receive their first dose intranasally.

is a serious unmet medical need. An acute treatment that can mitigate the pathological cascade could help so many people. We are excited

to get the Phase II clinical trials underway," commented Dr. James "Jim" Kelly, Neurologist and Executive Director

of the Marcus Institute of Brain Health and an advisor on the planned phase II trial.

has been shown to have a neuroprotective molecular profile and improve behavioral outcomes including memory and motor performance in

animal models of brain injury. The drug has a large safety margin between dosages used in the animal toxicology program and those used

in the Phase I study and planned for the upcoming Phase II clinical trial. Intranasal delivery of ONP-002 as a nanoparticle has been

shown to enhance brain exposure in animals. "Intranasal delivery targeting the brain is our model for improving brain health while

maintaining a strong safety margin," commented Michael Redmond, President of Oragenics.

is an unmet medical need. There is an estimated 69M concussions annually reported worldwide. Common causes of concussion include falls,

motor vehicle accidents and contact sports. Other neurological disorders including Alzheimer's Disease, Parkinson's Disease

and Chronic Traumatic Encephalopathy (CTE) have been linked to concussion. Post concussion syndrome is linked to long term disability

and occurs in as high as 20% of concussed patients.

communication contains "forward-looking statements" within the meaning of the safe harbor provisions of the U.S. Private

Securities Litigation Reform Act of 1995, including without limitation statements regarding the ability of the Company to timely and

successfully undertake Phase II clinical trial using its novel drug - device combination for the treatment of mild Traumatic Brain Injury.

These forward-looking statements are based on management's beliefs and assumptions and information currently available. The words

"believe," "expect," "anticipate," "intend," "estimate," "project"

and similar expressions that do not relate solely to historical matters identify forward-looking statements. Investors should be cautious

in relying on forward-looking statements because they are subject to a variety of risks, uncertainties, and other factors that could

cause actual results to differ materially from those expressed in any such forward-looking statements. These factors include, but are

not limited to: the Company's ability to advance the development of its product candidates, including the neurology assets, under

the timelines and in accord with the milestones it projects; the Company's ability to raise capital and obtain funding, non-dilutive

or otherwise, for the development of its product candidates; the regulatory application process, research and development stages, and

future clinical data and analysis relating to its product candidates, including any meetings, decisions by regulatory authorities, such

as the FDA and investigational review boards, whether favorable or unfavorable; the Company's ability to obtain, maintain and enforce

necessary patent and other intellectual property protection; the nature of competition and development relating to concussion treatments;

the Company's expectations as to the outcome of preclinical studies and clinical trials and the potential benefits, activity, effectiveness

and safety of its product candidates including as to administration, transmission, manufacturing, storage and distribution; and general

economic and market conditions and risks, as well as other uncertainties described in our filings with the U.S. Securities and Exchange

Commission. All information set forth is as of the date hereof unless otherwise indicated. You should consider these factors in evaluating

the forward-looking statements included and not place undue reliance on such statements. We do not assume any obligation to publicly

provide revisions or updates to any forward-looking statements, whether as a result of new information, future developments or otherwise,

should circumstances change, except as otherwise required by law.

Huffman, Chief Financial Officer