HISTOGENICS

HISTOGENICS CORPORATION ANNOUNCES PROPOSED PUBLIC OFFERING OF

COMMON STOCK AND WARRANTS

Mass., October 4, 2018 /GLOBE NEWSWIRE/ Histogenics Corporation (Histogenics) (Nasdaq: HSGX), a leader in the development of restorative cell therapies, today announced that it intends to offer and sell shares of its

common stock and accompanying warrants to purchase shares of common stock in an underwritten public offering. The offering is subject to market conditions, and there can be no assurance as to whether or when the offering may be completed, or as to

the actual size or terms of the offering. All of the securities in the offering are to be sold by Histogenics.

Histogenics intends to use the net

proceeds from the offering to complete the submission of the NeoCart biologics license application and prepare for commercialization of NeoCart following approval by the U.S. Food and Drug

Administration, if at all, and for general corporate purposes.

Canaccord Genuity LLC and BTIG, LLC are acting as the joint book-running managers for the

A shelf registration statement on Form S-3 (File

No. 333-216741) relating to the public offering of the shares of common stock and the accompanying warrants to purchase shares of common stock described above was filed with the Securities and Exchange

Commission (the SEC) and declared effective by the SEC on March 30, 2017. A preliminary prospectus supplement and accompanying prospectus relating to and describing the terms of the offering will be filed with the SEC and made available on the

SEC s web site at www.sec.gov. Copies of the preliminary prospectus supplement and accompanying prospectus relating to the offering, when available, may also be obtained by contacting Canaccord Genuity LLC, 99 High Street, Suite 1200, Boston,

MA 02110, Attn: Equity Syndicate Department, by telephone at (617) 371-3900 or by e-mail at prospectus@canaccordgenuity.com, or BTIG, LLC, 825 Third Avenue, 6th

Floor, New York, NY, 10022, or by telephone at (212) 593-7555 or by e-mail at equitycapitalmarkets@btig.com.

This press release does not constitute an offer to sell or the solicitation of an offer to buy any of these securities, nor will there be any sale of these

securities in any state or other jurisdiction in which such offer, solicitation or sale is not permitted.

About Histogenics Corporation

Histogenics (Nasdaq: HSGX) is a leader in the development of restorative cell therapies that may offer rapid-onset pain relief and restored function.

Histogenics lead investigational product, NeoCart, is designed to rebuild a patient s own knee cartilage to treat pain at the source and potentially prevent a patient s progression to osteoarthritis. NeoCart is one of the most

rigorously studied restorative cell therapies for orthopedic use. NeoCart is designed to perform like articular hyaline cartilage at the time of treatment, and as a result, may provide patients with more rapid pain relief and accelerated recovery as

compared to the current standard of care. Histogenics technology platform has the potential to be used for a broad range of additional restorative cell therapy indications.

Forward-Looking Statements

This press release contains

forward-looking statements, within the meaning of the Private Securities Litigation Reform Act of 1995, regarding, among other things, the proposed public offering of Histogenics common stock and warrants. Such forward-looking

statements are based on current expectations and involve inherent risks and uncertainties, including factors that could delay, divert or change any of them, and could cause actual results to differ materially from those projected in its

forward-looking statements. Meaningful factors which could cause actual results to differ, including completion of the proposed public

offering on the anticipated terms, or at all, market conditions and the satisfaction of customary closing conditions

related to the proposed public offering, as well as other factors, are discussed in the risks and uncertainties detailed from time to time in Histogenics filings with the SEC, including without limitation, under Histogenics Annual Report

on Form 10-K and Quarterly Reports on Form 10-Q. Histogenics undertakes no obligation to revise or update these forward-looking statements, whether as a result of new

information, future events or otherwise.

Tel: +1 (781) 547-7909