We caution you that this presentation contains forward-looking statements. All statements other than statements of historical facts contained in this presentation, including statements regarding our future results of ope

OmniAb, Inc. Nasdaq: OABI January 2023

We caution you that this presentation

contains forward-looking statements. All statements other than statements of historical facts contained in this presentation, including statements regarding our future results of operations and financial position, expected cash runway, business

strategy, our expectations regarding the application of, and the rate and degree of market acceptance of, our technology platform and other technologies, our expectations regarding the addressable markets for our technologies, including the growth

rate of the markets in which we operate, the timing of the initiation or completion of preclinical studies and clinical trials by our partners, expectations regarding product approvals and potential for future revenue growth, launches by our

partners and the timing thereof, and the potential for and timing of receipt of milestones and royalties under our license agreements with partners, are forward-looking statements. In some cases, you can identify forward-looking statements by terms

such as "may," "will," "should," "expect," "plan," "anticipate," "could," "intend," "target," "project,"

"contemplates," "believes," "estimates," "predicts," "potential" or "continue" or the negative of these terms or other similar expressions. The inclusion of forward-looking

statements should not be regarded as a representation by us that any of our plans will be achieved. Actual results may differ from those set forth in this presentation due to the risks and uncertainties inherent in our business, including, without

limitation: the anticipated benefits of our separation from Ligand may not be achieved; our future success is dependent on acceptance of our technology platform by new and existing partners, as well as on the eventual development, approval and

commercialization of products developed by our partners for which we have no control over the development plan, regulatory strategy or commercialization efforts; biopharmaceutical development is inherently uncertain, risks arising from changes in

technology; the competitive environment in the life sciences and biotechnology platform market; our failure to maintain, protect and defend our intellectual property rights; difficulties with performance of third parties we will rely on for our

business; regulatory developments in the United States and foreign countries; unstable market and economic conditions may have serious adverse consequences on our business, financial condition and stock price; we may use our capital resources sooner

than we expect; and other risks described in our press releases and filings with the SEC. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date made, and except as required by applicable

law, we do not plan to publicly update or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise. All forward-looking statements are qualified in their

entirety by this cautionary statement, which is made under the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Information regarding partnered products and programs comes from information publicly released by our

partners. This presentation also contains estimates and other statistical data made by independent parties and by us relating to market size and growth and other data about the antibody industry. This data involves a number of assumptions and

limitations, and you are cautioned not to give undue weight to such estimates. In addition, projections, assumptions, and estimates of our future performance and the future performance of the markets in which we operate are necessarily subject to a

high degree of uncertainty and risk. Disclaimer

OmniAb, Inc. ONE OF THE LARGEST

GREENFIELDS IN THE PHARMA INDUSTRY >65 partners HAVE ACCESS TO OMNIAB ANTIBODIES >280 Programs and 3 PRODUCT approvals Transgenic animals for fully human and Bispecific antibody Discovery LEADING AND PROVEN TECHNOLOGY INDUSTRY'S ONLY

4-SPECIES PLATFORM $279 Billion Total Addressable Market for Antibodies by 2025 OUR BUSINESS MODEL IS FOCUSED ON Licensing our proprietary DISCOVERY TECHNOLOGY Worldwide WE ARE MEETING A GLOBAL INDUSTRY NEED, POISED FOR GROWTH

Our mission is to enable the rapid

development of innovative therapeutics by pushing the frontiers of drug discovery technologies. Mission

Type of Drug Clinical Success Rates(1)

Small Molecules 7.5% Antibodies 12.1% Sources: Clarivate Analytics Cortellis database. Tables of approved mAbs and antibodies in review available at: https://www.antibodysociety.org/resources/approved-antibodies/ (1) Defined as composite

success rate of clinical development from Phase I trials to Approval, data from 2011-2020. Source: BIO | QLS Advisors | Informa Feb 2021 Report. Higher Success Rates Historical success rates for antibodies are significantly higher than small

molecules Antibodies and Industry Demand Higher clinical Success Rates for Antibody Medicines Drive our Industry's Need for Discovery Technology Increasing Antibody Market $279B in antibody sales by 2025 (up from ~$238B in 2022) 51 blockbuster

antibodies in 2022 5 best-selling antibodies had ~$75B of sales in 2022 Acceleration of Regulatory Approvals (FDA and EMA) Substantial growth in number of new antibody therapeutics

Growth of Partner Programs Progression

and Performance in Programs by Stage of Development 21 as of 2016(1) 282 as of 09/30/22 (1) Estimated at the time of acquisition of OMT, Inc. Substantial progress in all phases, increase in discovery programs expected to feed growth in new

clinical programs and future approvals

The OmniAb Platform We leverage our

proprietary and differentiated technologies, rather than commoditized industry services that are widely available from CROs or built into big pharma Create Diverse Pools of High-Quality Naturally-Optimized Antibodies Screen Millions of Cells to Find

Potential Therapeutic Candidates Further Characterize, Select & Optimize the Right Antibody Create Diverse Antibody Pools Screen Antibody Candidates Identify the Right Antibody Technology offering addresses critical industry needs and is paired

with our highly specialized and efficient operations Licenses to our technology platform are structured to align economic and scientific interests with our partners

The OmniAb Technology Offering

Technology offering addresses the most critical challenges of antibody discovery Technologies Create Diverse Antibody Pools Screen Antibody Candidates Identify the Right Antibody Create Diverse Pools of High-Quality Naturally-Optimized Antibodies

Screen Millions of Cells to Find Potential Therapeutic Candidates Further Characterize, Select & Optimize the Right Antibody Computational Antigen Design & Proprietary Reagents Robust Antibodies for Any Target Bispecific Antibody Generation

Cow-inspired Antibodies for Difficult Targets High-Throughput Single Cell Screening Gel Encapsulated Microenvironment (GEM) Single Cell Screening Custom Bioinformatics Next Generation Sequencing (NGS) Hit Expansion Comprehensive Functional

Characterization Proprietary Ion Channel Assays

What is Biological Intelligence ?

We believe that antibodies generated in vivo are superior to ones from other sources because they are naturally optimized through an iterative process that preferentially selects for antibodies with excellent specificity and developability profiles

The ability of the immune system in our engineered transgenic animals to create optimized antibodies for human therapeutics is what we call Biological Intelligence We believe this approach increases the efficiency and probability of success of

therapeutic antibody discovery and may help limit the attrition of antibody product candidates in the clinic

The OmniAb Platform We believe

generating large and diverse pools of high-quality antibodies increases the likelihood of discovering the antibody with the most desirable therapeutic characteristics Antibodies for Any Target Bispecific Antibody Generation Cow-inspired Antibodies

for Difficult Targets Computational Antigen Design & Proprietary Reagents Antibody Generation Technologies Industry's only 4-species platform A rich heritage of genetic engineering advancements Bispecific and cow-inspired technologies

enable next-generation therapeutics 3 approved and 22 active clinical-stage antibodies Carefully designed transgenes for robust response Screen Antibody Candidates Create Diverse Antibody Pools Identify the Right Antibody

Rodent Platforms Endogenous Ig genes

inactivated Expression of full human V gene diversity Streamlined conversion into fully human molecule Geurts et al. Science 2009 M noret et al. Eur J Immunol 2010 Osborn et al. J. Immunol. 2013 Well-validated transgene design utilizes rodent

constant regions for robust immune responses from the B-cell repertoire mRNA Human Antibody Light chain loci VL J CL + VJ C VH DH JH E CmCg1 C 2b e a Easy conversion Heavy chain locus VDJ C Rat constant Human V, D, J Fully human LC

OmniChicken Powered By

OmniTaur: Ultralong CDRH3s Create

Novel Binding Domains Unique structural features of ultralong H3 antibodies Novel structure may enable targeting epitopes unreachable by standard antibodies Long H3 domains can be expressed on human VH framework, or alone as ~5kD Picobodies

CDRH3 Human Cow Stanfield, et.al. Sci Adv (2020) 6(20): eaba0468.

Common Light Chain Platforms for

Bispecific Antibodies standard IgG format to de-risk downstream development The Evolution of Bispecifc Antibodies, Nimish Gera https://doi.org/10.1080/14712598.2022.2040987 Monospecific IgG Bispecific IgG Rearranged human VK3-15 light

chain combined with diversifying heavy chain JK2-5 Rearranged IgVK3-15/JK1 IgKC IgVK3-15/JK1 // Simple reformatting from monospecific into bispecific for efficient production "Germlining" human VK3-15 light chain combined with

diversifying heavy chain Common light chain for OmniFlic and OmniClic allows interchangeability between the platforms Bispecifics are a growing area of therapeutics (20% of mAbs in clinic) ~30% of new OmniAb programs seek to use OmniFlic or

Antibody Repertoires numerous

options available to address diverse partner objectives Host V genes Structural and immunological features Benefits for therapeutics discovery and development Full human V gene diversity Choice of light chain isotype Diverse V gene usage and

mixed genetic backgrounds Widely accessible and flexible workflows Full human V gene diversity Choice of light chain isotype Diverse V gene usage and mixed genetic backgrounds Distinctive target recognition Industry standard Widely accessible

and flexible workflows Extensive track record Single framework VH3/VK3 or VH3/VL1 Evolutionarily divergent host system for robust immune responses Diverse and new epitope coverage High homology targets Excellent physical properties Full human VH

gene diversity with non-diversifying VK3 Fixed light chain for bispecific applications Bispecific applications leveraging standard IgG format Single framework VH3/non-diversifying VK3 Fixed light chain for bispecific applications Diverse epitope

coverage Excellent physical properties Ease of manufacturing Single framework VH4/VL1 Ultralong CDR-H3's for enormous structural diversity Access cryptic epitopes Unique modalities (Picobodies ) Building blocks for multispecific

Screening Platforms Hybridoma

Workflow B-cell Workflow Immunization Isolate B-cells Sequence Bioinformatics enrichment optional Single-cell NGS Expression Validation Screen Fusion Technologies enable screening against difficult targets: GPCRs, ion channels and surface antigens

Our powerful single B-cell screening technologies, xPloration and GEM assay, bypass bottlenecks of hybridoma workflows AI-driven multi-parameter screening of tens of millions of cells in hours instead of weeks Screen Antibody Candidates Create

Diverse Antibody Pools Identify the Right Antibody

The OmniAb Platform Data from

multi-parameter screening and performance assays used in combination with bioinformatics NGS hit expansion to identify variant antibodies with improved characteristics High-throughput epitope binning and kinetics analysis, and target-specific

functional assays Proprietary assays for ion channel and transporter targets Our discovery teams are flexibly positioned to work closely with partners to identify the right antibody Screen Antibody Candidates Create Diverse Antibody Pools Identify

Create Diverse Pools of High-Quality

Naturally Optimized Antibodies Screen Millions of Cells to Find Potential Therapeutic Candidates Further Characterize, Select & Optimize the Right Antibody Create Diverse Antibody Pools Screen Antibody Candidates Identify the Right Antibody Ion

Channels and Transporters We Have Extensive biological capabilities FOR ion channels and transporters Proprietary cell lines enable high-speed antigen production Cutting-edge assays facilitate high-throughput screens in our GEM and xPloration

platforms Proprietary assays leveraged for discovery and characterization of antibodies Within OmniAb, Inc. are differentiated capabilities for viable target-to-lead delivery for difficult and high-value ion channel and transporter

Ion Channels and Transporters Ion

channels are key components in a wide variety of biological processes that involve rapid changes in cells Present in all human cells and affect such vital functions as nerve transmission, muscle contraction, cellular secretory processes and fluid

movement Have broad therapeutic applicability including metabolic diseases, pain, cancers, infectious diseases, others In the search for novel drugs, ion channels are viewed as high-value targets

Leveraging Biological

Intelligence with Computational Tools Biological Intelligence Differentiated sources of antibody sequences In silico developability Sequence liability assessment Comparison to clinical antibodies Structure-based calculations Sequence

databases and bioinformatics Customized cloud-based antibody sequence databases Large-scale repertoire analysis Model-aided optimization Antibody homology modeling Computational antibody optimization

Antibody Repertoire Source Used

ACTIVE Partner PROGRAMS DISTRIBUTION OF ANTIBODY REPERTOIRE SOURCES USED TOGETHER FOR BISPECIFICS SOURCE USAGE 24% 62% 14% + + + Multi-species platform provides partners even more diverse repertoires and new target access Common light chain techs

being used for flexibility and bispecific program optionality

Diverse Drug Formats and Modalities

PRECLINICAL AND CLINICAL OMNIAB MOLECULES Duobody (IgG4 exchange) ADAPTIR scFv-Fc-scFv IgG IgG-scFv Antibody-Drug Conjugate Fab-Heavy chain (Knob-in-hole) Variety in the formats and modalities used by partners is demonstrating the

flexibility of our platform MODALITIES FORMATS Bispecific (incl. T cell engager) 37%

Select OmniAb Partners >65

companies currently have access to omniab ANTIBODIES

Key Performance Indicators Strong

annual growth in key performance indicators continues Active Partners:(1) >30% CAGR 2014 through 2021 Active Programs:(2) >25% CAGR 2016 through 2021 Metrics as of 9/30/22 position our business for strong growth Technology and business model

are highly scalable Represents the unique number of partners with whom we have active license agreements or who have an active program. Represents programs for which an antigen is introduced into our animals and remains so as long as the program is

actively being developed or commercialized. * Active Programs not tracked prior to acquisition of Open Monoclonal Technology, Inc. in January 2016. Number of Active Programs Number of Active Clinical Programs and Approved Products *

Intellectual Property Advantage

Antibody Patent Applications Filed by Partners PARTNERS FILING PATENTS ON OMNIAB-DERIVED ANTIBODIES can CREATE DIVERSE AND DURABLE ROYALTY STREAMS AND A LENGTHY IP TAIL >65 patent filings by our partners claiming an OmniAb-derived antibody

as primary invention, with expiries up to 2041 We maintain a broad intellectual property estate with multiple long duration patent families covering each major element of our technology platform Licenses are structured so that royalties are linked

to the patents for the antibodies discovered with OmniAb, thereby creating a lengthy coverage tail Over 300 patents issued worldwide Patents include: WO2015167293A1, WO2017020291A1, WO2017024515A1, WO2017024146A1, WO2017031104A1, WO2017053748A2,

WO2017059196A2, WO2017059243A2, WO2017079121A2, WO2017178493A1, WO2017192567A1, WO2017223111A1, WO2018054241A1, US20180105600A1, WO2018057802 A1, WO2018069500A2, WO2018091661A1, WO2018095932A1, WO2018119016A1, WO2018119246A1, WO2018162749A1,