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Nuvalent to Present New Preclinical Data for HER2-Selective Inhibitor, NVL-330, at AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics Nuvalent, Inc. (Nasdaq: NUVL), a clinical-stage biopharmaceutical company focused on creating precisely targeted therapies for clinically proven...

Key Takeaway: Nuvalent, Inc. announced it will present new preclinical data for its HER2-selective inhibitor, NVL-330, at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston from October 22-26, 2025. The poster presentation will detail the preclinical intracranial activity of NVL-330, which is designed to target HER2 effectively. The conference presents an opportunity to showcase this targeted therapy aimed at overcoming the limitations of existing cancer treatments. This development is part of Nuvalent's broader focus on creating innovative therapies for various cancer indications.

Market Sentiment Analysis

POSITIVE FACTORS

  • Nuvalent is presenting promising preclinical data for NVL-330 at a major conference.
  • The company focuses on targeted therapies, which may enhance treatment options for cancer.
  • NVL-330 specifically targets HER2, a critical aspect in cancer treatment advancements.

Full Press Release Details

CAMBRIDGE, Mass. , Oct. 13, 2025 /PRNewswire/ -- Nuvalent, Inc. (Nasdaq: NUVL ), a clinical-stage biopharmaceutical company focused on creating precisely targeted therapies for clinically proven kinase targets in cancer, today announced an upcoming poster presentation further characterizing the preclinical intracranial activity of its novel HER2-selective inhibitor, NVL-330, at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics being held October 22-26, 2025 in Boston.
Details of the poster presentation are as follows:
Title: Preclinical intracranial activity of NVL-330, a selective HER2 tyrosine kinase inhibitor Abstract Number: B057 Authors: Yuting Sun* 1 , Kristin L. Andrews 1 , Anupong Tangpeerachaikul 1 , Michael J. Walsh 1 , Nancy E. Kohl 2 , Joshua C. Horan 1 , Henry E. Pelish 1 Session: Poster Session B Session Date and Time: Friday, October 24, 2025, 12:30-4:00 p.m. ET Location: Exhibit Hall D
*Presenter, corresponding author; 1 Nuvalent, Inc., Cambridge, MA, USA; 2 Kohl Consulting, Wellesley, MA, USA
About Nuvalent Nuvalent, Inc. (Nasdaq: NUVL ) is a clinical-stage biopharmaceutical company focused on creating precisely targeted therapies for patients with cancer, designed to overcome the limitations of existing therapies for clinically proven kinase targets. Leveraging deep expertise in chemistry and structure-based drug design, we develop innovative small molecules that have the potential to overcome resistance, minimize adverse events, address brain metastases, and drive more durable responses. Nuvalent is advancing a robust pipeline with investigational candidates for ROS1-positive, ALK-positive, and HER2-altered non-small cell lung cancer, and multiple discovery-stage research programs.
SOURCE Nuvalent, Inc.

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Frequently Asked Questions

What is NVL-330?

NVL-330 is a novel HER2-selective tyrosine kinase inhibitor developed by Nuvalent.

When will the NVL-330 poster presentation occur?

The poster presentation is scheduled for October 24, 2025, from 12:30 to 4:00 p.m. ET.

Where will the AACR-NCI-EORTC conference take place?

The conference will be held in Boston from October 22-26, 2025.

What is Nuvalent's focus area?

Nuvalent focuses on creating targeted therapies for cancer with kinase targets.

What types of cancer does Nuvalent target?

Nuvalent targets ROS1-positive, ALK-positive, and HER2-altered non-small cell lung cancer.

Last updated: Oct 13, 2025