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Medicare Expands Coverage for Signatera™ MRD Test in Hepatocellular Carcinoma

Key Takeaway: Natera, Inc. announced that its Signatera MRD test has received Medicare coverage for hepatocellular carcinoma (HCC). The Centers for Medicare & Medicaid Services (CMS) will cover serial testing in surveillance for early-stage HCC patients post-surgery. This expansion supports the use of precision medicine in cancer treatment.

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POSITIVE FACTORS

  • Medicare expanded coverage for Signatera MRD test.
  • Coverage includes serial testing for early-stage HCC.
  • This supports precision medicine in cancer care.

Full Press Release Details

AUSTIN, Texas--(BUSINESS WIRE)--Natera, Inc. (NASDAQ: NTRA), a global leader in cell-free DNA and precision medicine, today announced that its Signatera molecular residual disease (MRD) test has received Medicare coverage through the Centers for Medicare & Medicaid Services’ (CMS) Molecular Diagnostics Services Program (MolDX) in hepatocellular carcinoma (HCC). The coverage includes serial Signatera testing in the surveillance setting for patients with early-stage HCC who have no post-surgi

Frequently Asked Questions

What is the Signatera MRD test?

The Signatera MRD test is a molecular residual disease test used in cancer surveillance.

Who announced the Medicare coverage?

Natera, Inc. announced the Medicare coverage for the Signatera MRD test.

What type of cancer does the coverage apply to?

The coverage applies to hepatocellular carcinoma (HCC).

What does the coverage include?

It includes serial Signatera testing for early-stage HCC patients.

Last updated: Nov 3, 2026