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NeOnc CEO Buys More Shares Below $5 as NTHI Secures FDA Meeting to Discuss Phase 3 Trial

Key Takeaway: NeOnc Technologies Holdings' CEO Amir Heshmatpour purchased an additional 70,000 shares, totaling 150,000 shares recently. The company secured an FDA Type B meeting to discuss a potential accelerated approval pathway for NEO100. The upcoming meeting will also address the design of a Phase 3 trial for recurrent or progressive IDH-mutant grade 4 astrocytoma.
Price reaction · baseline $4.45 (2026-11-12T15:12:00.000Z) · hit during market hours · clean, no other NTHI news in the window
day 0 close · peak
+9%

Market Sentiment Analysis

POSITIVE FACTORS

  • CEO Amir Heshmatpour increased his shareholding significantly.
  • FDA meeting scheduled to discuss accelerated approval for NEO100.
  • Positive Phase 2a findings support future discussions.
  • Roth MKM reaffirmed a Buy rating with a $20 price target.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Cash runway
~3 mo
High dilution risk
Lead asset
NEO100
Phase 2 · Glioblastoma Multiforme

Full Press Release Details

DALLAS, Nov. 12, 2026 (GLOBE NEWSWIRE) -- (www.InvestorsTape.com)— NeOnc Technologies Holdings (NASDAQ: NTHI) CEO Amir Heshmatpour has purchased another 70,000 shares in the open market, bringing his recent purchases to 150,000 shares as the company approaches important clinical and regulatory milestones.
The latest transactions represent approximately $294,500, with purchases reaching $4.49 per share. Combined with the preceding 80,000-share purchases announced by NeOnc, Heshmatpour committed approximately $563,582 across November 5–11.

Our bullish interpretation: the CEO continues putting personal capital behind his conviction as NeOnc’s development story advances.

The CEO Keeps Buying Higher

The latest filing summary details three purchases:
Transaction date Shares purchased Reported price
November 10 50,000 $4.192 weighted average
November 11 10,000 $4.49
November 11 10,000 $4.00
Total 70,000 Approximately $4.207 average
The transactions increased Heshmatpour’s reported direct holdings to 3,333,000 shares, separate from his indirectly held positions.
NeOnc previously announced purchases of 80,000 shares across November 5, 6 and 9, totaling approximately $269,082 using personal funds.

The progression stands out. Earlier purchases came in the low-to-mid $3 range. The CEO continued adding above $4, including a transaction at $4.49.

These open-market purchases increase his ownership as investors evaluate the company’s next milestones. Roth MKM also recently reaffirmed its Buy rating and $20 price target, maintaining its bullish valuation.

FDA Meeting Puts Phase 3 and Accelerated Approval on the Agenda

On November 11, NeOnc announced that the FDA granted a Type B End-of-Phase meeting scheduled for early January 2027 to discuss a potential accelerated approval pathway for intranasal NEO100.
NeOnc intends to seek feedback on whether its clinical and nonclinical evidence could support an accelerated approval application for recurrent or progressive IDH-mutant grade 4 astrocytoma.
The company will also seek agreement on NEO100-012, a proposed randomized Phase 3 trial comparing NEO100 with investigator-selected standard-of-care chemotherapy. Overall survival would be the primary endpoint, with the study intended to provide registrational and confirmatory evidence.
NeOnc now has an FDA discussion scheduled around a potential approval pathway and the design of a Phase 3 trial. Positive Phase 2a findings provide the foundation for that discussion and give investors a defined next step to follow.

Two Programs. Several Dates to Watch.

The January meeting adds to an already active calendar:
• November 13: Updated NEO100 Phase 1/2a results and NEO212 Phase 1 data are scheduled for presentation at the Society for Neuro-Oncology Annual Meeting.
• November 17: NeOnc’s FDA End-of-Phase 1 meeting for NEO212 is scheduled to address proposed Phase 2 development and next steps.
• Early January 2027: The newly announced NEO100 meeting will address its potential accelerated approval pathway and proposed Phase 3 trial.
Two investigational drugs, upcoming scientific presentations, separate FDA discussions and continued CEO buying give investors several developments to watch.

A Larger Short Position Adds Potential Fuel

The latest short-interest update puts NTHI at approximately 921,000 shares short as of October 30, compared with 876,682 on October 15.
That represents an increase of roughly 44,000 shares before the stock’s recent advance through $4.
Updated NEO100 data and NEO212 Phase 1 findings are scheduled for presentation at this week’s Society for Neuro-Oncology annual meeting.
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Forward-Looking Statements This press release contains forward-looking statements within the meaning of applicable securities laws, including statements that may regard NeOnc Technologies Holdings’ future revenue, growth trajectory, profitability outlook, expansion plans, strategic partnerships, potential regulatory approvals, and other projections, plans, and objectives. Forward-looking statements are subject to risks and uncertainties that may cause actual results to differ materially from those expressed or implied, including market conditions, timing of venue openings, execution risks, operational performance, competition, regulatory matters, and general economic conditions. Readers should not place undue reliance on these statements, which speak only as of the date made.
General Disclaimer: InvestorsTape.com has been compensated for press and editorial coverage of NeOnc Technologies Holdings and further disclosure information is available here. This communication is provided for informational and journalistic purposes only and reflects the independent editorial views of InvestorsTape.com.
This editorial discusses investigational therapy and clinical-trial results and is not medical advice or a recommendation to buy or sell securities. This publication is protected speech under the First Amendment of the United States Constitution. Nothing herein constitutes an offer, solicitation, or recommendation to buy or sell any security, nor should it be construed as investment advice. Investing in securities involves risk, including the possible loss of principal. Readers are encouraged to conduct their own due diligence and consult with a qualified financial advisor before making any investment decision.

Frequently Asked Questions

What recent purchases did NeOnc's CEO make?

CEO Amir Heshmatpour bought 70,000 shares, totaling 150,000 shares recently.

What is the purpose of the FDA meeting?

The meeting will discuss a potential accelerated approval pathway for NEO100.

What is the primary endpoint of the Phase 3 trial?

Overall survival is the primary endpoint for the proposed Phase 3 trial.

What did Roth MKM say about NeOnc's stock?

Roth MKM reaffirmed a Buy rating with a $20 price target for NTHI.

Last updated: Nov 12, 2026