Full Press Release Details
Announces Publication of the
IRON-GUARD Registry in EuroIntervention
incidence of major adverse cardiovascular events
including no major strokes
MA-May 17, 2017 - InspireMD, Inc. (NYSE MKT:NSPR) (NYSE MKT:NSPR.WS) ("InspireMD" or the "Company"),
a leader in embolic prevention systems (EPS) / thrombus management technologies and neurovascular devices, today announced the
publication of the Investigator Initiated IRON-GUARD Italian clinical registry in the peer reviewed journal EuroIntervention,
which appeared in the May 9th issue. IRON-GUARD was an independent, multicentre, multi-disciplinary clinical study treating patients
with carotid artery disease using the CGuardTM EPS (embolic prevention system) in 12 Italian centers.
IRON-GUARD registry enrolled 200 patients, and showed results of 100% technical success placing the device, and zero incidence
of major adverse cardiovascular events (MACE), comprised of death, major stroke or myocardial infarction, in all patients at 30
days. Five (2.5%) minor strokes and two transient ischemic attacks (1%) were observed, which were resolved by 30 days.
authors included Professor Carlo Setacci, MD, Francesco Spezialie, MD; Laura Capoccia, MD; Pasqualino Sirignano, MD; Wassim Mansour,
MD: Chiara Pranteda, MD; and Renato Casana, MD.
Francesco Spezialie, stated, "In our multi-center, multi-specialty experience, use of the CGuard EPS in routine clinical
practice was associated with no major peri-procedural neurologic complications and a total elimination of post-procedural neurologic
complications after 30 days. The CGuard EPS has shown itself to be a promising treatment for carotid lesions."
Barry, PhD, Chief Executive Officer of InspireMD, commented, "We were pleased to see the results of the IRON-GUARD registry
accepted and published in EuroIntervention. These results further validate the positive clinical outcomes of other trials and
registries utilizing CGuardTM EPS and the data is quite consistent with those other clinical trials. To our knowledge,
this now appears to be the largest registry utilizing CGuard. Following on from the very successful Paradigm 101 study, IRON-GUARD
is a further high quality independent registry which continues to give us confidence in CGuard becoming the standard-of-care for
treatment of carotid artery disease due to the significant safety advantages of our device."
is a monthly peer-reviewed journal of interventional cardiovascular medicine that has become one of the benchmarks in its field.
EuroIntervention is the official journal of EuroPCR and the European Association of Percutaneous Cardiovascular Interventions
(EAPCI). The Journal is endorsed by the European Society of Cardiology (ESC) and has a distinguished European and International
editorial board led by Prof Patrick W. Serruys from the Erasmus MC, Rotterdam.
seeks to utilize its proprietary MicroNet technology to make its products the industry standard for embolic protection
and to provide a superior solution to the key clinical issues of current stenting in patients with a high risk of distal embolization,
no reflow and major adverse cardiac events.
intends to pursue applications of this MicroNet technology in coronary, carotid (CGuard ), neurovascular, and peripheral
artery procedures. InspireMD's common stock is quoted on the NYSE MKT under the ticker symbol NSPR and certain warrants
are quoted on the NYSE MKT under the ticker symbol NSPR.WS.
press release contains "forward-looking statements." Such statements may be preceded by the words "intends,"
"may," "will," "plans," "expects," "anticipates," "projects,"
"predicts," "estimates," "aims," "believes," "hopes," "potential"
or similar words. Forward-looking statements are not guarantees of future performance, are based on certain assumptions and are
subject to various known and unknown risks and uncertainties, many of which are beyond the Company's control, and cannot
be predicted or quantified and consequently, actual results may differ materially from those expressed or implied by such forward-looking
statements. Such risks and uncertainties include, without limitation, risks and uncertainties associated with (i) market acceptance
of our existing and new products, (ii) negative clinical trial results or lengthy product delays in key markets, (iii) an inability
to secure regulatory approvals for the sale of our products, (iv) intense competition in the medical device industry from much
larger, multinational companies, (v) product liability claims, (vi) product malfunctions, (vii) our limited manufacturing capabilities
and reliance on subcontractors for assistance, (viii) insufficient or inadequate reimbursement by governmental and other third
party payers for our products, (ix) our efforts to successfully obtain and maintain intellectual property protection covering
our products, which may not be successful, (x) legislative or regulatory reform of the healthcare system in both the U.S. and
foreign jurisdictions, (xi) our reliance on single suppliers for certain product components, (xii) the fact that we will need
to raise additional capital to meet our business requirements in the future and that such capital raising may be costly, dilutive
or difficult to obtain and (xiii) the fact that we conduct business in multiple foreign jurisdictions, exposing us to foreign
currency exchange rate fluctuations, logistical and communications challenges, burdens and costs of compliance with foreign laws
and political and economic instability in each jurisdiction. More detailed information about the Company and the risk factors
that may affect the realization of forward looking statements is set forth in the Company's filings with the Securities
and Exchange Commission (SEC), including the Company's Annual Report on Form 10-K and its Quarterly Reports on Form 10-Q.
Investors and security holders are urged to read these documents free of charge on the SEC's web site at http://www.sec.gov.
The Company assumes no obligation to publicly update or revise its forward-looking statements as a result of new information,
future events or otherwise.