InspireMD Announces Publication of 12-Month Results of CGuard EPS SIBERIA Trial in Journals of the American College of Cardiology: Cardiovascular Interventions Tel Aviv, Israel

Announces Publication of 12-Month Results of

CGuard EPS SIBERIA Trial in Journals of the American

College of Cardiology: Cardiovascular Interventions

Aviv, Israel- November 3, 2021 - InspireMD, Inc. (Nasdaq: NSPR), developer of the CGuard Embolic Prevention System

(EPS) for the prevention of stroke caused by the treatment of Carotid Artery Disease (CAD), today announced that results from the investigator-initiated

SIBERIA randomized clinical trial of CGuard EPS, that evaluated the peri-procedural and 30-day silent brain infarcts associated with

the use of its MicroNetTM covered stent (CGuard) versus a conventional "workhorse" open-cell Acculink nitinol

stent were published this week. The principal investigator study was published in Journals of the American College of Cardiology (JACC)

and is titled Randomized Controlled Trial of Conventional Versus MicroNet-Covered Stent in Carotid Artery Revascularization.

main findings of the study included:

randomized control study evaluated 30-day silent brain infarcts associated with the use of the Acculink conventional open-cell nitinol

stent vs the CGuard MicroNet-covered stent. The Micronet-covered stent significantly reduced periprocedural cerebral embolism, showing

an average of 57% reduction in lesion per patient (171 mm3 vs 73 mm3 (P = 0.017)) and a 4.5 fold reduction

in total volume of periprocedural lesions (701 mm3 vs 157 mm3 (P = 0.007)) when compared to Acculink. Additionally,

postprocedural (48 hours to 30 day) cerebral was abolished by the MicroNet covered stent, while it was ongoing with the conventional,

first-generation carotid stent.

are very pleased with the results of the SIBERIA trial and the subsequent publication, as the first randomized, controlled clinical trial

to directly compare CGuard EPS head-to-head against a widely used conventional stent," said

Marvin Slosman, Chief Executive Officer of InspireMD. "The study highlights our growing body of real-world clinical evidence as

well as scientific evidence showing the superiority of the CGuard device in preventing brain embolization. This proprietary technology

has the potential to change the standard of care and help physicians make better treatment decisions for the management of stroke and

overall carotid artery disease. We are excited to further demonstrate the technology behind CGuard EPS with our C-Guardians registrational

trial in the United States, for which we are currently enrolling patients."

seeks to utilize its proprietary MicroNet technology to make its products the industry standard for carotid stenting by providing outstanding

acute results and durable, stroke-free, long-term outcomes. InspireMD's common stock is quoted on the Nasdaq under the ticker symbol

NSPR, and certain warrants are quoted on the Nasdaq under the symbol NSPRZ.

press release contains "forward-looking statements." Such statements may be preceded by the words "intends,"

"may," "will," "plans," "expects," "anticipates," "projects,"

"predicts," "estimates," "aims," "believes," "hopes," "potential",

"scheduled" or similar words. For example, the company is using forward-looking statements when it discusses that the study

highlights growing evidence of the superiority of the CGuard device in preventing brain embolization and that the technology has the

potential to change the standard of care and help physicians make better treatment decisions for the management of stroke and overall

carotid artery disease. Forward-looking statements are not guarantees of future performance,

are based on certain assumptions and are subject to various known and unknown risks and uncertainties, many of which are beyond the company's

control, and cannot be predicted or quantified and consequently, actual results may differ materially from those expressed or implied

by such forward-looking statements. Such risks and uncertainties include, without limitation, risks and uncertainties associated with

(i) market acceptance of our existing and new products, (ii) negative clinical trial results or lengthy product delays in key markets,

(iii) an inability to secure regulatory approvals for the sale of our products, (iv) intense competition in the medical device industry

from much larger, multinational companies, (v) product liability claims, (vi) product malfunctions, (vii) our limited manufacturing capabilities

and reliance on subcontractors for assistance, (viii) insufficient or inadequate reimbursement by governmental and other third party

payers for our products, (ix) our efforts to successfully obtain and maintain intellectual property protection covering our products,

which may not be successful, (x) legislative or regulatory reform of the healthcare system in both the U.S. and foreign jurisdictions,

(xi) our reliance on single suppliers for certain product components, (xii) the fact that we will need to raise additional capital to

meet our business requirements in the future and that such capital raising may be costly, dilutive or difficult to obtain and (xiii)

the fact that we conduct business in multiple foreign jurisdictions, exposing us to foreign currency exchange rate fluctuations, logistical

and communications challenges, burdens and costs of compliance with foreign laws and political and economic instability in each jurisdiction.

More detailed information about the Company and the risk factors that may affect the realization of forward-looking statements is set

forth in the Company's filings with the Securities and Exchange Commission (SEC), including the Company's Annual Report on

Form 10-K and its Quarterly Reports on Form 10-Q. Investors and security holders are urged to read these documents free of charge on

the SEC's web site at http://www.sec.gov. The Company assumes no obligation to publicly update or revise its forward-looking statements

as a result of new information, future events or otherwise.

Padala, Managing Director