Full Press Release Details
Reports Second Quarter 2022 Financial Results
SAN FRANCISCO, August
4, 2022 /PRNewswire/ -- Nektar Therapeutics (Nasdaq: NKTR) today reported financial results for the second quarter ended June
Cash and investments
in marketable securities at June 30, 2022, were approximately $628.2 million as compared to $798.8 million at December
31, 2021, which is expected to support operations into 2025.
last several months, we developed and began implementing a new strategic plan that prioritizes specific investment into the most
promising biologic therapeutic candidates in the pipeline, NKTR-358, NKTR-255, and key research programs," said Howard W.
Robin, President and CEO of Nektar. "With our partner, Eli Lilly, NKTR-358 is advancing, and we will be presenting in
September data from a Phase 1b study in atopic dermatitis patients and in the first half of 2023 data from a Phase 2 study
in lupus patients. Our plan provides Nektar with the opportunity to create significant value for our shareholders and to focus
our internal development efforts on the potential of NKTR-255, our wholly owned IL-15 program, in combination with cell therapies
and other mechanisms in both liquid and solid tumor settings. Importantly, we also have the required capital to fund our pipeline to
reach potential value-inflection points for each program."
Summary of Financial
Revenue, which primarily
includes non-cash royalty revenue, in the second quarter of 2022 was $21.6 million as compared to $28.3 million in the second quarter
of 2021. Revenue for the first half of 2022 was $46.4 million as compared to $52.0 million in the first half of 2021. Total operating
costs and expenses in the second quarter of 2022 were $174.4 million as compared to $138.5 million in the second quarter of 2021. Total
operating costs and expenses in the first half of 2022 were $315.8 million as compared to $271.6 million in the first half of 2021. Operating
costs and expenses for both the second quarter and first half of 2022 include $57.3 million in non-cash impairment charges and $27.8 million
in severance expense relating to the wind down of the bempegaldesleukin program.
second quarter of 2022 was $42.7 million as compared to $101.3 million for the second quarter of 2021. For the first half of 2022, R&D
expense was $150.0 million as compared to $196.9 million in the first half of 2021. R&D expense decreased for both the second quarter
and first half of 2022 due to the wind down of the bempegaldesleukin program.
G&A expense was $20.5
million in the second quarter of 2022 and $29.6 million in the second quarter of 2021. For the first half of 2022, G&A expense was
$47.9 million as compared to $61.2 million in the first half of 2021. G&A expense decreased for both the second quarter and first
half of 2022 due to the wind down of the bempegaldesleukin program.
We recorded $106.0 million
in restructuring, impairment and other costs of terminated program in the second quarter of 2022, related to the wind down of the bempegaldesleukin
program. This includes the $57.3 million in non-cash lease and equipment impairment charges, $27.8 million in severance expense and $21.0
million primarily for clinical trial and related employee compensation costs for the bempegaldesleukin program.
Net loss for the second
quarter of 2022 was $159.1 million or $0.85 basic and diluted loss per share as compared to a net loss of $125.5 million or $0.69 basic
and diluted loss per share in the second quarter of 2021. Net loss in the first half of 2022 was $249.5 million or $1.34 basic and diluted
loss per share as compared to a net loss of $248.5 million or $1.37 basic and diluted loss per share in the first half of 2021.
and Recent Business Highlights:
Discuss Second Quarter 2022 Financial Results
Nektar management will
host a conference call to review the results beginning at 5:00 p.m. Eastern Time/2:00 p.m. Pacific Time, Thursday, August 4, 2022.
This press release and
a live audio-only Webcast of the conference call can be accessed through a link that is posted on the home page and Investors section
of the Nektar website: https://ir.nektar.com/. The web broadcast of the conference call will be available for replay through September
To access the conference
call, follow these instructions:
Dial: (833) 634-2591 (U.S); (412) 317-6040 (international)
In the event that any
non-GAAP financial measure is discussed on the conference call that is not described in this press release, or explained on the conference
call, related information will be made available on the Investors section of the Nektar website as soon as practical after the conclusion
of the conference call.
About Nektar Therapeutics
Nektar Therapeutics is
a biopharmaceutical company with a robust, wholly owned R&D pipeline of investigational medicines in oncology, immunology, and inflammatory
diseases as well as a portfolio of approved partnered medicines. Nektar is headquartered in San Francisco, California, with additional
operations in Huntsville, Alabama. Further information about the company and its drug development programs and capabilities may be found
online at http://www.nektar.com.
Regarding Forward-Looking Statements
contains forward-looking statements which can be identified by words such as: "will," "may," "extend," "potential,"
"create," "provide"" and similar references to future periods. Examples of forward-looking statements include,
among others, statements we make regarding the therapeutic potential of, and future development plans for NKTR-358, NKTR-255 and our other
drug candidates in research programs, the prospects and plans for our collaborations with other companies, the timing of the initiation
of clinical studies and the data readouts for our drug candidates, and our expectations (including our expected charges and cost savings)
following our corporate restructuring, reorganization and workforce reduction, and our expected working capital our cash runway. Forward-looking
statements are neither historical facts nor assurances of future performance. Instead, they are based only on our current beliefs, expectations
and assumptions regarding the future of our business, future plans and strategies, anticipated events and trends, the economy and other
future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks and changes
in circumstances that are difficult to predict and many of which are outside of our control. Our actual results may differ materially
from those indicated in the forward-looking statements. Therefore, you should not rely on any of these forward-looking statements. Important
factors that could cause our actual results to differ materially from those indicated in the forward-looking statements include, among
others: (i) our statements regarding the therapeutic potential of NKTR-358, NKTR-255 and our other drug candidates are based on
preclinical and clinical findings and observations and are subject to change as research and development continue; (ii) NKTR-358, NKTR-255
and our other drug candidates are investigational agents and continued research and development for these drug candidates is subject to
substantial risks, including negative safety and efficacy findings in ongoing clinical studies (notwithstanding positive findings in earlier
preclinical and clinical studies); (iii) NKTR-358, NKTR-255 and our other drug candidates are in various stages of clinical development
and the risk of failure is high and can unexpectedly occur at any stage prior to regulatory approval; (iv) the timing of the commencement
or end of clinical trials and the availability of clinical data may be delayed or unsuccessful due to challenges caused by the COVID-19
pandemic, regulatory delays, slower than anticipated patient enrollment, manufacturing challenges, changing standards of care, evolving
regulatory requirements, clinical trial design, clinical outcomes, competitive factors, or delay or failure in ultimately obtaining regulatory
approval in one or more important markets; (v) we may not achieve the expected costs savings we expect from the restructuring and reorganization,
(vi) patents may not issue from our patent applications for our drug candidates, patents that have issued may not be enforceable, or additional
intellectual property licenses from third parties may be required; and (vii) certain other important risks and uncertainties set forth
in our Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on May 6, 2022. Any forward-looking
statement made by us in this press release is based only on information currently available to us and speaks only as of the date on which
it is made. We undertake no obligation to update any forward-looking statement, whether written or oral, that may be made from time to
time, whether as a result of new information, future developments or otherwise.
Vivian Wu of Nektar Therapeutics
CONDENSED CONSOLIDATED BALANCE SHEETS
| June 30, 2022 | December 31, 2021 (1) | |||||||
| ASSETS | ||||||||
| Current assets: | ||||||||
| Cash and cash equivalents | $ | 77,545 | $ | 25,218 | ||||
| Short-term investments | 541,771 | 708,737 | ||||||
| Accounts receivable | 10,006 | 22,492 | ||||||
| Inventory | 16,969 | 15,801 | ||||||
| Other current assets | 19,245 | 23,333 | ||||||
| Total current assets | 665,536 | 795,581 | ||||||
| Long-term investments | 8,928 | 64,828 | ||||||
| Property, plant and equipment, net | 39,792 | 60,510 | ||||||
| Operating lease right-of-use assets | 68,996 | 117,025 | ||||||
| Goodwill | 76,501 | 76,501 | ||||||
| Other assets | 2,234 | 2,744 | ||||||
| Total assets | $ | 861,987 | $ | 1,117,189 | ||||
| LIABILITIES AND STOCKHOLDERS' EQUITY | ||||||||
| Current liabilities: | ||||||||
| Accounts payable | 12,346 | 9,747 | ||||||
| Accrued compensation | 30,323 | 15,735 | ||||||
| Accrued clinical trial expenses | 29,234 | 26,809 | ||||||
| Other accrued expenses | 13,035 | 15,468 | ||||||
| Operating lease liabilities, current portion | 20,047 | 17,441 | ||||||
| Total current liabilities | 104,985 | 85,200 | ||||||
| Operating lease liabilities, less current portion | 119,415 | 125,736 | ||||||
| Development derivative liability | - | 27,726 | ||||||
| Liabilities related to the sales of future royalties, net | 176,775 | 195,427 | ||||||
| Other long-term liabilities | 2,080 | 3,592 | ||||||
| Total liabilities | 403,255 | 437,681 | ||||||
| Commitments and contingencies | ||||||||
| Stockholders' equity: | ||||||||
| Preferred stock | - | - | ||||||
| Common stock | 19 | 19 | ||||||
| Capital in excess of par value | 3,549,360 | 3,516,641 | ||||||
| Accumulated other comprehensive loss | (8,191 | ) | (4,157 | ) | ||||
| Accumulated deficit | (3,082,456 | ) | (2,832,995 | ) | ||||
| Total stockholders' equity | 458,732 | 679,508 | ||||||
| Total liabilities and stockholders' equity | $ | 861,987 | $ | 1,117,189 |
CONDENSED CONSOLIDATED STATEMENTS
(In thousands, except per share information)
| Three months ended June 30, | Six months ended June 30, | |||||||||||||||
| 2022 | 2021 | 2022 | 2021 | |||||||||||||
| Revenue: | ||||||||||||||||
| Product sales | $ | 5,312 | $ | 7,846 | $ | 11,000 | $ | 12,641 | ||||||||
| Non-cash royalty revenue related to the sales of future royalties | 16,264 | 20,456 | 33,825 | 39,254 | ||||||||||||
| License, collaboration and other revenue | 9 | 28 | 1,582 | 82 | ||||||||||||
| Total revenue | 21,585 | 28,330 | 46,407 | 51,977 | ||||||||||||
| Operating costs and expenses: | ||||||||||||||||
| Cost of goods sold | 5,115 | 7,667 | 10,430 | 13,423 | ||||||||||||
| Research and development | 42,740 | 101,313 | 149,993 | 196,917 | ||||||||||||
| General and administrative | 20,521 | 29,555 | 47,860 | 61,234 | ||||||||||||
| Restructuring, impairment and other costs of terminated program | 106,045 | - | 107,520 | - | ||||||||||||
| Total operating costs and expenses | 174,421 | 138,535 | 315,803 | 271,574 | ||||||||||||
| Loss from operations | (152,836 | ) | (110,205 | ) | (269,396 | ) | (219,597 | ) | ||||||||
| Non-operating income (expense): | ||||||||||||||||
| Change in fair value of development derivative liability | - | (2,713 | ) | 33,427 | (4,312 | ) | ||||||||||
| Non-cash interest expense on liabilities related to the sales of future royalties | (7,228 | ) | (13,089 | ) | (14,757 | ) | (26,385 | ) | ||||||||
| Interest income and other income (expense), net | 1,096 | 845 | 1,491 | 2,257 | ||||||||||||
| Total non-operating expense, net | (6,132 | ) | (14,957 | ) | 20,161 | (28,440 | ) | |||||||||
| Loss before provision for income taxes | (158,968 | ) | (125,162 | ) | (249,235 | ) | (248,037 | ) | ||||||||
| Provision for income taxes | 100 | 357 | 226 | 449 | ||||||||||||
| Net loss | $ | (159,068 | ) | $ | (125,519 | ) | $ | (249,461 | ) | $ | (248,486 | ) | ||||
| Basic and diluted net loss per share | $ | (0.85 | ) | $ | (0.69 | ) | $ | (1.34 | ) | $ | (1.37 | ) | ||||
| Weighted average shares outstanding used in computing basic and diluted net loss per share | 186,800 | 182,698 | 186,323 | 182,038 |
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
| Six months ended June 30, | ||||||||
| 2022 | 2021 | |||||||
| Cash flows from operating activities: | ||||||||
| Net loss | $ | (249,461 | ) | $ | (248,486 | ) | ||
| Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||
| Non-cash royalty revenue related to the sales of future royalties | (33,825 | ) | (39,254 | ) | ||||
| Non-cash interest expense on liabilities related to the sales of future royalties | 14,757 | 26,385 | ||||||
| Change in fair value of development derivative liability | (33,427 | ) | 4,312 | |||||
| Non-cash research and development expense | 4,951 | 5,795 | ||||||
| Stock-based compensation | 32,064 | 47,612 | ||||||
| Depreciation and amortization | 7,171 | 7,090 | ||||||
| Impairment of right-of-use assets and property, plant and equipment | 57,321 | - | ||||||
| Amortization of premiums (discounts), net and other non-cash transactions | 700 | 4,090 | ||||||
| Changes in operating assets and liabilities: | ||||||||
| Accounts receivable | 12,486 | 10,018 | ||||||
| Inventory | (1,168 | ) | 676 | |||||
| Operating leases, net | 1,486 | 2,260 | ||||||
| Other assets | 7,627 | 11,585 | ||||||
| Accounts payable | 2,833 | (2,101 | ) | |||||
| Accrued compensation | 14,588 | 14,133 | ||||||
| Other accrued expenses | (1,520 | ) | (4,101 | ) | ||||
| Net cash used in operating activities | (163,417 | ) | (159,986 | ) | ||||
| Cash flows from investing activities: | ||||||||
| Purchases of investments | (247,014 | ) | (527,887 | ) | ||||
| Maturities of investments | 466,423 | 612,419 | ||||||
| Sales of investments | - | 5,035 | ||||||
| Purchases of property, plant and equipment | (4,983 | ) | (6,157 | ) | ||||
| Net cash provided by investing activities | 214,426 | 83,410 | ||||||
| Cash flows from financing activities: | ||||||||
| Proceeds from shares issued under equity compensation plans | 655 | 28,523 | ||||||
| Cash receipts from development derivative liability | 750 | 1,500 | ||||||
| Net cash provided by financing activities | 1,405 | 30,023 | ||||||
| Effect of foreign exchange rates on cash and cash equivalents | (87 | ) | (57 | ) | ||||
| Net increase (decrease) in cash and cash equivalents | 52,327 | (46,610 | ) | |||||
| Cash and cash equivalents at beginning of period | 25,218 | 198,955 | ||||||
| Cash and cash equivalents at end of period | $ | 77,545 | $ | 152,345 | ||||
| Supplemental disclosure of cash flow information: | ||||||||
| Operating lease right-of-use assets recognized in exchange for lease liabilities | $ | - | $ | 1,057 |