BioNTech and Matinas BioPharma Announce Exclusive Research Collaboration to Evaluate Novel Delivery Technology for mRNA-based Vaccines Exclusive collaboration combines BioNTech's mRNA vaccine development expertise and Ma

and Matinas BioPharma Announce Exclusive Research Collaboration to Evaluate Novel Delivery Technology for mRNA-based Vaccines

Germany and BEDMINSTER, New Jersey (USA), April 11 2022 - BioNTech SE (Nasdaq:

BNTX, "BioNTech") and Matinas BioPharma (NYSE AMER: MTNB, "Matinas"), a clinical-stage

biopharmaceutical company focused on redefining the intracellular delivery of nucleic acids and small molecules with its lipid nanocrystal

(LNC) platform technology, announced today that they have entered into an exclusive research collaboration to evaluate the combination

of mRNA formats and Matinas' proprietary LNC platform technology. The parties will closely collaborate on formulation, optimization,

and in vitro testing.

pioneered the treatment of the first patient in history with nano-sized lipid-encapsulated mRNA back in 2015, after years of extensive

research. Accomplishing strong immune responses with low doses are crucial in the development of well-tolerated and highly effective

vaccines. This can be achieved with the right technology that enables targeted vaccine delivery," said Ugur Sahin, M.D., Chief

Executive Officer and Co-Founder of BioNTech. "Matinas' LNC platform demonstrates encouraging capabilities for intracellular

delivery, including the opportunity for oral delivery. We are excited to collaborate with this extraordinary team of experts."

collaboration with BioNTech is an important validation from a leading global biotech company with demonstrated expertise in the design,

formulation, and delivery of mRNA," said Jerome D. Jabbour, Chief Executive Officer and Co-Founder of Matinas. "We

are thrilled to partner with this world-class organization to further demonstrate the capabilities of our LNC platform, and potentially

provide an opportunity for the oral administration of vaccines or other treatments. Intracellular delivery remains a significant challenge

for many emerging therapies and the combination of oral bioavailability with non-immunogenic transfection could potentially benefit tens

of millions of patients around the world."

the terms of the agreement, Matinas will receive an upfront access fee to work exclusively with BioNTech, as well as additional research

funding from BioNTech. The parties have also commenced discussions on a license agreement for Matinas' LNC platform technology.

New Technologies is a next generation immunotherapy company pioneering novel therapies for cancer and other serious diseases. The Company

exploits a wide array of computational discovery and therapeutic drug platforms for the rapid development of novel biopharmaceuticals.

Its broad portfolio of oncology product candidates includes individualized and off-the-shelf mRNA-based therapies, innovative chimeric

antigen receptor T cells, bi-specific checkpoint immuno-modulators, targeted cancer antibodies and small molecules. Based on its deep

expertise in mRNA vaccine development and in-house manufacturing capabilities, BioNTech and its collaborators are developing multiple

mRNA vaccine candidates for a range of infectious diseases alongside its diverse oncology pipeline. BioNTech has established a broad

set of relationships with multiple global pharmaceutical collaborators, including Genmab, Sanofi, Bayer Animal Health, Genentech, a member

of the Roche Group, Regeneron, Genevant, Fosun Pharma and Pfizer.

more information, please visit www.BioNTech.de.

Forward-looking Statements

press release contains "forward-looking statements" of BioNTech within the meaning of the Private Securities Litigation Reform

Act of 1995. These forward-looking statements may include, but may not be limited to, statements concerning: BioNTech's collaboration

with Matinas; the ability of Matinas' LNC delivery platform to facilitate the intracellular delivery of nucleic acids following

oral administration; and the ability of BioNTech to commercialize mRNA medicines using the LNC delivery platform, if successfully developed.

Any forward-looking statements in this press release are based on BioNTech current expectations and beliefs of future events and are

subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth

in or implied by such forward-looking statements.

a discussion of these and other risks and uncertainties, see the section entitled "Risk Factors" in BioNTech's Annual

Report on Form 20-F for the Year Ended December 31, 2021, filed with the SEC on March 30, 2022, which is available on the SEC's

website at www.sec.gov. All information in this press release is as of the date of the release, and BioNTech undertakes no duty

to update this information unless required by law.

BioPharma is a biopharmaceutical company focused on redefining the intracellular delivery of nucleic acids and small molecules with its

lipid nanocrystal (LNC) platform technology. The Company is developing its own internal portfolio of products as well as partnering with

leading pharmaceutical companies to develop novel formulations that capitalize on the unique characteristics of the LNC platform.

and clinical data have demonstrated that this novel technology can provide solutions to many of the challenges in achieving safe and

effective intracellular delivery, for both small molecules and larger, more complex molecules, such as mRNA, DNA plasmids, antisense

oligonucleotides and vaccines. The combination of a unique mechanism of action and flexibility with formulation and route of administration

(including oral), positions Matinas' LNC technology to potentially become one of the leading next-generation intracellular drug

more information, please visit www.matinasbiopharma.com.

Forward-looking Statements

release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995,

including those relating to our business activities, our strategy and plans, our collaboration with BioNTech, the potential of our LNC

platform delivery technology, and the future development of its product candidates, the Company's ability to identify and pursue

development, licensing and partnership opportunities for its products or platform delivery technology on favorable terms, if at all,

and the ability to obtain required regulatory approval and other statements that are predictive in nature, that depend upon or refer

to future events or conditions. All statements other than statements of historical fact are statements that could be forward-looking

statements. Forward-looking statements include words such as "expects," "anticipates," "intends,"

"plans," "could," "believes," "estimates" and similar expressions. These statements involve

known and unknown risks, uncertainties and other factors which may cause actual results to be materially different from any future results

expressed or implied by the forward-looking statements. Forward-looking statements are subject to a number of risks and uncertainties,

including, but not limited to, our ability to obtain additional capital to meet our liquidity needs on acceptable terms, or at all, including

the additional capital which will be necessary to complete the clinical trials of our product candidates; our ability to successfully

complete research and further development and commercialization of our product candidates; the uncertainties inherent in clinical testing;

the timing, cost and uncertainty of obtaining regulatory approvals; our ability to protect the Company's intellectual property;

the loss of any executive officers or key personnel or consultants; competition; changes in the regulatory landscape or the imposition

of regulations that affect the Company's products; and the other factors listed under "Risk Factors" in our filings

with the SEC, including Forms 10-K, 10-Q and 8-K. Investors are cautioned not to place undue reliance on such forward-looking statements,

which speak only as of the date of this release. Except as may be required by law, the Company does not undertake any obligation to release

publicly any revisions to such forward-looking statements to reflect events or circumstances after the date hereof or to reflect the

occurrence of unanticipated events. Matinas BioPharma's product candidates are all in a development stage and are not available