Full Press Release Details
CAMBRIDGE, Mass., Nov. 12, 2018 (GLOBE NEWSWIRE) -- Mersana Therapeutics, Inc. (NASDAQ:MRSN), a clinical-stage biopharmaceutical company focused on discovering and developing a pipeline of antibody drug conjugates (ADCs) based on its Dolaflexin® and other proprietary platforms, today announced it will present data on two new, novel antibody-drug conjugate (ADC) platforms at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics taking place November 13-16, 2018, in Dublin, Ireland. Additionally, the company will present pre-clinical data on the efficacy of XMT-1522 in NSCLC patient-derived xenograft models.
"We are excited about the potential of these novel, complementary ADC platforms to expand the scope of our future drug development programs,” said Timothy B. Lowinger, Ph.D., Chief Scientific Officer, Mersana Therapeutics. “The Dolasynthen platform offers us a fully homogeneous platform to control the drug-to-antibody ratio (DAR) precisely from 2-24 to match it optimally to a given target. In addition, Alkymer, our novel DNA damaging agent platform, provides us the ability to address a broader range of cancer indications.”
Details of the presentations are as follows:
XMT-1522 is a Dolaflexin ADC targeting HER2-expressing tumors. XMT-1522 comprises a proprietary HER2 antibody which is conjugated with Mersana’s Dolaflexin platform – a Fleximer polymer linked with a proprietary auristatin payload. XMT-1522 provides a drug load of approximately 12 molecules per antibody, specifically designed to improve potency while simultaneously increasing tolerability. XMT-1522 has the potential to extend HER2-targeted therapy beyond the current “HER2-positive” populations into patients with lower levels of HER2 expression. The Phase 1 protocol will evaluate XMT-1522 in patients with advanced HER2-positive breast and gastric cancer, as well as advanced breast cancer with low HER2 expression and non-small cell lung cancer. More information on the ongoing Phase 1 clinical study can be found at clinicaltrials.gov.
About Mersana Therapeutics
Mersana Therapeutics is a clinical-stage biopharmaceutical company using its differentiated and proprietary ADC platforms to develop highly targeted drugs with increased tolerability and expanded opportunities to deliver meaningful clinical benefit to patients. Mersana’s product candidate XMT-1522 is in Phase 1 clinical trials in patients with advanced tumors expressing HER2, including breast cancer, non-small-cell-lung-cancer (NSCLC) and gastric cancer patients. The Company’s second product candidate, XMT-1536, is in Phase 1 clinical trials in patients with tumors expressing NaPi2b, including ovarian cancer, NSCLC and other cancers. In addition, multiple partners are using Mersana’s platform to advance their ADC pipelines.
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