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MIMEDX Announces Publication in the Journal of Inflammation Focused on Immunomodulatory Effects of Purion® Processed Human Amniotic Membrane Allografts In Vitro

Key Takeaway: MiMedx Group, Inc. announced a new publication in the Journal of Inflammation detailing the immunomodulatory effects of its Purion processed human amniotic membrane allografts. The study found that both DHACM and LHACM products effectively regulate inflammatory responses, which could enhance wound healing. This research adds to MiMedx's extensive body of evidence supporting its innovative products.
Price reaction · baseline $7.25 (2025-12-18 close) · hit pre-market · 1 other MDXG headline(s) in the window, move may be shared
day 0 close · peak
-2.8%

Market Sentiment Analysis

POSITIVE FACTORS

  • Publication supports MIMEDX's scientific credibility.
  • Demonstrates immunomodulatory properties of DHACM and LHACM.
  • Contributes to a comprehensive library of clinical research.
  • Aligns with the emphasis on high-quality evidence in healthcare.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Cash runway
~40 mo
Low dilution risk
Lead asset
Micronized DHACM
Phase 3 · Tendonitis;Achilles

Full Press Release Details

MARIETTA, Ga., Dec. 19, 2025 (GLOBE NEWSWIRE) -- MiMedx Group, Inc. (Nasdaq: MDXG) (“MIMEDX” or the “Company”) today announced the latest addition to its industry-leading body of scientific and clinical evidence supporting the use of its dehydrated human amnion chorion membrane (DHACM) and lyophilized human amnion chorion membrane (LHACM) products, in theJournal of Inflammation. The article, “Immunomodulatory Effects of Purion Processed Human Amniotic Membrane AllograftsIn Vitro” can be accessed onlinehere.
“Our team has once again demonstrated MIMEDX’s commitment to generating robust and impactful peer-reviewed research, highlighting the capacity of our technology and the products that are derived from our proprietary tissue processing methodology,” stated Joseph H. Capper, MIMEDX Chief Executive Officer. “In this latest publication, we were pleased to find that our DHACM and LHACM allografts exhibited immunomodulatory properties that correspond with the beneficial outcomes we observe in the clinical setting. This study marks another important contribution to our comprehensive library of clinical and scientific research, which has positioned us favorably in our marketplace, especially considering the renewed emphasis the pending Local Coverage Determinations (LCDs) place on the production of high-quality evidence.”
The study evaluated two configurations of Purion processed placental allografts, DHACM and LHACM, for their ability to regulate key cell types in the inflammatory cascade. The findings illustrate a multifactorial immunomodulatory effect whereby DHACM and LHACM allografts regulate critical functions of inflammatory monocyte and macrophage biology, while enhancing pro-reparative functions including efferocytosis and cell survival. This study is highly relevant, as complex wounds are frequently characterized by persistent inflammation within the wound bed, which contributes to chronicity and poor clinical outcomes; therefore, DHACM and LHACM represent promising interventions to help restore and reset the normal wound-healing cascade.
About MIMEDXMIMEDX is a pioneer and leader focused on helping humans heal. With more than a decade of helping clinicians manage chronic and other hard-to-heal wounds, MIMEDX provides a leading portfolio of products for applications in the wound care, burn, and surgical sectors of healthcare. The Company’s vision is to be the leading global provider of healing solutions through relentless innovation to restore quality of life. For additional information, please visitwww.mimedx.com.

Contact:Matt NotarianniInvestor Relations470-304-7291mnotarianni@mimedx.com

Frequently Asked Questions

What did the MIMEDX study focus on?

The study focused on the immunomodulatory effects of DHACM and LHACM allografts.

Where was the MIMEDX study published?

The study was published in the Journal of Inflammation.

What are DHACM and LHACM?

DHACM and LHACM are dehydrated and lyophilized human amnion chorion membrane products.

How do MIMEDX products aid wound healing?

They regulate inflammatory responses and enhance pro-reparative functions.

Last updated: Dec 19, 2025