Full Press Release Details
Seres Therapeutics Reports Fourth Quarter and Full Year 2017 Financial Results and
Provides Business Updates
- Positive SER-287 Phase 1b clinical and microbiome results support further
development; Company plans to initiate next clinical trial in mid-2018 -
- Preliminary Phase 1b study data obtained for SER-262, the first ever
rationally-designed fermented microbiome therapeutic candidate evaluated in humans
with MD Anderson and Parker Institute intends to initiate clinical study in 2018 to evaluate microbiome therapeutics enhancing immuno-oncology treatments
- Conference call at 8:00 a.m. ET today -
CAMBRIDGE, Mass., March 8, 2018 Seres Therapeutics, Inc. (Nasdaq:MCRB), a leading microbiome therapeutic development company
developing a novel class of biological drugs, today reported fourth quarter and full year 2017 financial results and provided operational and strategic updates.
2017 was a year of significant pipeline progress where Seres obtained promising SER-287 Phase 1b clinical and
microbiome results in Ulcerative Colitis, advanced SER-109 into a pivotal Phase 3 study for recurrent C. difficile infection, and entered into a strategic collaboration with MD Anderson and the Parker
Institute for Cancer Immunotherapy to initiate a clinical study to evaluate microbiome therapy effects in improving the efficacy of checkpoint inhibitors in cancer patients, said Roger J. Pomerantz, M.D., President, CEO and Chairman of Seres.
Seres also recently obtained preliminary SER-262 Phase 1b study results in patients with primary C. difficile infection. The SER-262 results, the first ever
from a rationally designed microbiome development candidate, provide key mechanistic insights that will inform the progress of Seres microbiome therapeutic candidates, including but not limited to
Dr. Pomerantz continued: Seres has an array of early and late clinical stage, as well
as pre-clinical stage microbiome programs in infectious, metabolic, and immune diseases - each with compelling scientific and clinical rationale. Our near-term focus will be on the highest priority clinical
programs to most effectively advance our pipeline: SER-287 for Ulcerative Colitis; SER-109 for Recurrent C. difficile infection; and the SER-401 Immuno-oncology program. We expect 2018 to be an eventful year with continued SER-109 Phase 3 study execution, and the initiation of both a next stage SER-287 Ulcerative Colitis clinical study, as well as a clinical trial evaluating adjunctive microbiome therapy in metastatic melanoma patients being treated with checkpoint inhibitors.
SER-287 administration resulted in a dose-dependent improvement of both clinical remission rates and
endoscopic scores. Based on an intent to treat missing data counted as a failure analysis, 40% (6 of 15) of patients in the vancomycin pre-treatment, daily
SER-287 dosing arm achieved clinical remission; whereas in the placebo group 0% (0 of 11) achieved this endpoint (p-value = 0.0237).
High clinical response rates to placebo that were not statistically differentiated from the SER-287
treatment arms were also observed. Clinical response is a subjective endpoint that is prone to high variability and high placebo rates, as previously observed in several other UC trials. In the most recent FDA regulatory guidance in August 2016,
clinical remission is the only recommended primary endpoint in UC registrational studies.
SER-287 safety and tolerability profile was favorable. Study results demonstrated no imbalance in adverse events in patients treated with SER-287, as compared to
placebo. There were no drug-related serious adverse events associated with SER-287.
study microbiome data demonstrated that SER-287 induced dose-dependent engraftment of SER-287-derived bacterial species.
Differences in specific bacterial engraftment signatures were found to be associated with clinical remission. Bacterial engraftment of SER-287-derived bacterial species
was durable for at least four weeks after administration of the final SER-287 dose, when final data microbiome samples were collected. In the 11 patients in this trial who achieved clinical remission (all of
whom received SER-287), none had flares during the 6 months following SER-287 treatment. Finally, histologic improvement scores were demonstrated to be higher in
patients treated with daily SER-287, as compared to placebo.
Seres is in discussion with the FDA
regarding the SER-287 study design and plans to initiate the next clinical study of SER-287 in UC patients in mid-2018.
Preliminary SER-262 microbiome analysis has been conducted on the first five, lowest dose cohorts to
assess drug pharmacokinetics. A majority of SER-262-derived strains were detected in patients receiving SER-262; detection of
strains was variable across subjects. This is the first-time engraftment of bacteria from a fermented microbiome drug candidate has been demonstrated in the microbiome of humans. Partial engraftment of strains was also a characteristic observed in
our SER-109 clinical studies, and has been reported in fecal microbiota transplant treatment of C. difficile infection. In patients where SER-262
engraftment was observed, broader microbiome changes were also observed, indicating that a limited number of engrafting species may cause global restructuring of the human microbiome. Microbiome profile differences, based on the antibiotics used to
treat each patient s C. difficile infection, were also observed. Vancomycin led to more rapid and robust engraftment of SER-262 bacterial strains, as compared to Metronidazole. More detailed
microbiome and metabolomic analyses remain ongoing. These unique SER-262 proprietary human data sets will be used to inform future development of SER-262 and other
fermented Seres therapeutic candidate, including but not limited to SER-301 for Inflammatory bowel disease (IBD) and SER-155 for hematopoietic stem cell transplantation
Seres reported a net loss of $89.4 million for the full year, as compared to a net loss of $91.6 million for the prior year. Seres
reported a net loss of $29.0 million for the fourth quarter of 2017, as compared to a net loss of $25.3 million for the same period in 2016. The fourth quarter net loss was driven primarily by clinical and development expenses,
personnel expenses, and ongoing development of the Company s microbiome therapeutics platform. The fourth quarter net loss figure was inclusive of $3.1 million in recognized revenue associated with the Company s collaboration
with Nestl Health Science.
Research and development expenses for the fourth quarter 2017 were $24.0 million, as compared to $20.3
million for the same period in 2016. The research and development expense was primarily related to Seres microbiome therapeutics platform, the clinical development of SER-109, SER-262 and SER-287, as well as the Company s and immuno-oncology preclinical programs.
General and administrative expenses for the fourth quarter were $8.8 million, as compared to $8.5 million for the same period in the prior
year. General and administrative expenses were primarily due to headcount, professional fees, and facility costs.
The decrease in the Company s
cash, cash equivalents and investments balance during the quarter was $21.3 million. Seres ended the fourth quarter with approximately $150.0 million in cash, cash equivalents and investments.
Financial Expectations
Based on the Company s
current operating plan, cash resources are expected to fund operating expenses and capital expenditure requirements, excluding net cash flows from future business development activities or potential incoming milestone payments, through the first
This projection is a revision to the previous cash funding timing guidance of through 2018.
Seres is eligible to receive a substantial milestone payment, not considered in the financial guidance update, associated with the planned initiation of the
next SER-287 clinical study.
Conference Call Information
Seres management will host a conference call today, March 8, 2018, at 8:00 a.m. ET. To access the conference call, please dial (844) 277-9450 (domestic) or (336) 525-7139 (international) and reference the conference ID number 5092388. Accompanying slides will be made available on the Seres website prior to
the call. To join the live webcast, please visit the Investors and Media section of the Seres website at www.serestherapeutics.com.
A webcast replay will be available on the Seres website beginning approximately two hours after the event and will be archived for approximately 21 days.
About Seres Therapeutics
Seres Therapeutics, Inc.,
(Nasdaq:MCRB) is a leading microbiome therapeutics platform company developing a novel class of biological drugs that are designed to treat disease by restoring the function of a dysbiotic microbiome, where the natural state of bacterial diversity
and function is imbalanced. Seres lead program, SER-109, has obtained Breakthrough Therapy and Orphan Drug designations from the U.S. Food and Drug Administration and is in Phase 3 development for
multiply recurrent C. difficile infection. Seres clinical candidate SER-287 has successfully completed a Phase 1b study in patients with mild-to-moderate Ulcerative Colitis. Seres is also evaluating SER-262, a rationally-designed microbiome therapeutic candidate, in a Phase 1b study in patients with
Forward-looking Statements
This press release contains
forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements,
including relating to our prioritization of our assets, our development plans, the ability of ECOSPOR III to support SER-109 approval, ECORSPOR III enrollment, the promise and potential impact of any of our
microbiome therapeutics or clinical trial data, our plans to initiate clinical studies of SER-287 and in I-O, the timing and results of any clinical studies, and the
sufficiency of cash to fund operations.
These forward-looking statements are based on management s current expectations. These statements are
neither promises nor guarantees, but involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or
achievements expressed or implied by the forward-looking statements, including, but not limited to, the following: we have incurred significant losses, are not currently profitable and may never become profitable; our need for additional funding;
our limited operating history; our unproven approach to therapeutic intervention; the lengthy, expensive, and uncertain process of clinical drug development, including potential delays in regulatory approval; our reliance on third parties and
collaborators to conduct our clinical trials, manufacture our product candidates, and develop and commercialize our product candidates, if approved; our lack of experience in manufacturing,
selling, marketing, and distributing our product candidates; failure to compete successfully against other drug companies; protection of our proprietary technology and the confidentiality of our
trade secrets; potential lawsuits for, or claims of, infringement of third-party intellectual property or challenges to the ownership of our intellectual property; our patents being found invalid or unenforceable; risks associated with international
operations; our ability to retain key personnel and to manage our growth; the potential volatility of our common stock; our management and principal stockholders have the ability to control or significantly influence our business; and we are
currently subject to securities class action litigation. These and other important factors discussed under the caption Risk Factors in our Quarterly Report on Form 10-Q filed with the Securities
and Exchange Commission, or SEC, on November 8, 2017 and our other reports filed with the SEC, including the Annual Report we intend to file later today, could cause actual results to differ materially from those indicated by the
forward-looking statements made in this press release. Any such forward-looking statements represent management s estimates as of the date of this press release. While we may elect to update such forward-looking statements at some point in the
future, we disclaim any obligation to do so, even if subsequent events cause our views to change. These forward-looking statements should not be relied upon as representing our views as of any date subsequent to the date of this press release.
Carlo Tanzi, Ph.D., Seres
Therapeutics, 617-203-3467
Vice President, Investor Relations and
Corporate Communications
SERES THERAPEUTICS, INC.
CONSOLIDATED BALANCE SHEETS
(In thousands, except share and per share data)
| December 31, | ||||||||
| 2017 | 2016 | |||||||
| Assets | ||||||||
| Current assets: | ||||||||
| Cash and cash equivalents | $ | 36,088 | $ | 54,539 | ||||
| Investments | 113,895 | 138,704 | ||||||
| Prepaid expenses and other current assets | 5,095 | 5,126 | ||||||
| Total current assets | 155,078 | 198,369 | ||||||
| Property and equipment, net | 32,931 | 36,125 | ||||||
| Long-term investments | 36,752 | |||||||
| Restricted cash | 1,513 | 1,400 | ||||||
| Total assets | $ | 189,522 | $ | 272,646 | ||||
| Liabilities and Stockholder s Equity | ||||||||
| Current liabilities: | ||||||||
| Accounts payable | $ | 7,033 | $ | 7,587 | ||||
| Accrued expenses and other current liabilities | 12,513 | 10,812 | ||||||
| Deferred revenue - related party | 12,079 | 12,058 | ||||||
| Total current liabilities | 31,625 | 30,457 | ||||||
| Lease incentive obligation, net of current portion | 8,989 | 10,730 | ||||||
| Deferred rent | 2,233 | 2,072 | ||||||
| Deferred revenue, net of current portion - related party | 84,847 | 96,756 | ||||||
| Other long-term liabilities | 1,129 | |||||||
| Total liabilities | 128,823 | 140,015 | ||||||
| Commitments and contingencies | ||||||||
| Stockholders equity: | ||||||||
| Preferred stock, $0.001 par value; 10,000,000 shares authorized at December 31, 2017 and 2016; no shares issued and outstanding at December 31, 2017 and 2016 | ||||||||
| Common stock, $0.001 par value; 200,000,000 shares authorized at December 31, 2017 and 2016; 40,571,015 and 40,355,753 shares issued and outstanding at December 31, 2017 and 2016 | 40 | 40 | ||||||
| Additional paid-in capital | 324,376 | 306,931 | ||||||
| Accumulated other comprehensive income (loss) | (146 | ) | (149 | ) | ||||
| Accumulated deficit | (263,571 | ) | (174,191 | ) | ||||
| Total stockholders equity | 60,699 | 132,631 | ||||||
| Total liabilities, convertible preferred stock and stockholders equity | $ | 189,522 | $ | 272,646 |
SERES THERAPEUTICS, INC.
CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS
(In thousands, except share and per share data)
| Year Ended December 31, | ||||||||||||
| 2017 | 2016 | 2015 | ||||||||||
| Revenue: | ||||||||||||
| Collaboration revenue - related party | $ | 32,100 | $ | 21,766 | $ | |||||||
| Total revenue | 32,100 | 21,766 | ||||||||||
| Operating expenses: | ||||||||||||
| Research and development expenses | $ | 89,455 | 81,989 | 38,095 | ||||||||
| General and administrative expenses | 34,040 | 32,616 | 16,761 | |||||||||
| Total operating expenses | 123,495 | 114,605 | 54,856 | |||||||||
| Loss from operations | (91,395 | ) | (92,839 | ) | (54,856 | ) | ||||||
| Other income (expense): | ||||||||||||
| Interest income (expense), net | 1,590 | 1,260 | 83 | |||||||||
| Other income | 425 | |||||||||||
| Revaluation of preferred stock warrant liability | (7 | ) | ||||||||||
| Total other income (expense), net | 2,015 | 1,260 | 76 | |||||||||
| Net loss | $ | (89,380 | ) | (91,579 | ) | (54,780 | ) | |||||
| Net loss per share attributable to common stockholders, basic and diluted | $ | (2.21 | ) | $ | (2.30 | ) | $ | (2.33 | ) | |||
| Weighted average common shares outstanding, basic and diluted | 40,449,410 | 39,846,928 | 23,532,400 | |||||||||
| Other comprehensive income (loss): | ||||||||||||
| Unrealized gain (loss) on investments, net of tax of $0 | 3 | (179 | ) | 30 | ||||||||
| Total other comprehensive income (loss) | 3 | (179 | ) | 30 | ||||||||
| Comprehensive loss | $ | (89,377 | ) | $ | (91,758 | ) | $ | (54,750 | ) |