Full Press Release Details
Biotechnology Announces Master Clinical Supply Agreement with
for Hard-to-Treat Cancer Therapies
- June 18, 2025 - MAIA Biotechnology, Inc. (NYSE American: MAIA), a clinical-stage biopharmaceutical company focused
on developing targeted immunotherapies for cancer, today announced its entry into a clinical master supply agreement with Roche for future
studies investigating the combination of MAIA's telomere-targeting agent ateganosine (THIO), sequenced with Roche's checkpoint
inhibitor (CPI), atezolizumab (Tecentriq ), for the treatment of multiple hard-to-treat cancers.
preclinical studies, ateganosine was found to be highly synergistic and effective in combination with Roche's anti-PD-L1 agent
atezolizumab," said MAIA Chairman and CEO Vlad Vitoc, M.D. "We are pleased to partner with world-renowned Roche and we look
forward to further strengthening our mission to find safe and effective cancer treatments."
(THIO, 6-thio-dG or 6-thio-2'-deoxyguanosine) is a first-in-class investigational telomere-targeting agent currently in clinical
development to evaluate its activity in non-small cell lung cancer (NSCLC). Telomeres, along with the enzyme telomerase, play a fundamental
role in the survival of cancer cells and their resistance to current therapies. The modified nucleotide 6-thio-2'-deoxyguanosine
induces telomerase-dependent telomeric DNA modification, DNA damage responses, and selective cancer cell death. Ateganosine-damaged telomeric
fragments accumulate in cytosolic micronuclei and activate both innate (cGAS/STING) and adaptive (T-cell) immune responses. The sequential
treatment with ateganosine followed by PD-(L)1 inhibitors resulted in profound and persistent tumor regression in advanced, in vivo cancer
models by induction of cancer type-specific immune memory. Ateganosine is presently developed as a second or later line of treatment
for NSCLC for patients that have progressed beyond the standard-of-care regimen of existing checkpoint inhibitors.
MAIA Biotechnology, Inc.
is a targeted therapy, immuno-oncology company focused on the development and commercialization of potential first-in-class drugs with
novel mechanisms of action that are intended to meaningfully improve and extend the lives of people with cancer. Our lead program is
ateganosine (THIO), a potential first-in-class cancer telomere targeting agent in clinical development for the treatment of NSCLC patients
with telomerase-positive cancer cells. For more information, please visit www.maiabiotech.com.
(atezolizumab) is a registered trademark of Genentech, a member of the Roche Group.
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