Recent Updates
Recently added Catalysts
LUCD Positive Sentiment

Lucid Diagnostics Announces Updated National Comprehensive Cancer Network® (NCCN) Guidelines Now Include Esophageal Precancer Screening

Key Takeaway: Lucid Diagnostics has reported a significant update to the National Comprehensive Cancer Network (NCCN) Guidelines, which now include recommendations for esophageal precancer screening. The updated guidelines endorse non-endoscopic biomarker testing, particularly Lucid's EsoGuard Esophageal DNA Test, as a worthy alternative to invasive procedures. This is expected to improve insurance policy coverage for esophageal precancer testing and enhance patient access to early detection measures, thereby potentially preventing esophageal cancer. Lucid continues to focus on cancer prevention efforts targeting at-risk populations, particularly those with gastroesophageal reflux disease.
Price reaction · baseline $1.5 (2025-03-19 close) · hit after-hours · 1 other LUCD headline(s) in the window, move may be shared
day 0 close · peak
+4.7%

Market Sentiment Analysis

POSITIVE FACTORS

  • Update in NCCN guidelines acknowledging the importance of esophageal precancer screening.
  • EsoGuard DNA test is now viewed as a viable non-invasive alternative to endoscopy.
  • Potential for increased commercial insurance coverage and accessibility for patients.

Full Press Release Details

Highlights society guidelines recommending non-endoscopic biomarker testing, such as Lucid's EsoGuard Esophageal DNA Test, as an acceptable alternative to endoscopy
NEW YORK, March 20, 2025 /PRNewswire/ -- Lucid Diagnostics Inc. (Nasdaq: LUCD) ("Lucid" or the "Company"), a commercial-stage, cancer prevention medical diagnostics company, and subsidiary of PAVmed Inc. (Nasdaq: PAVM), today announced that a recent update to the National Comprehensive Cancer Network® (NCCN) Clinical Practice Guidelines in Oncology (NCCN Guidelines®) focused on Esophageal and Esophagogastric Junction Cancers (Version 1.2025) has added a new section on esophageal precancer (Barrett's Esophagus or BE) screening. The NCCN Guidelines® now reference professional society guidelines on BE screening, including the most recent American College of Gastroenterology (ACG) Clinical Guideline which recommends non-endoscopic biomarker testing, such as Lucid's EsoGuard® Esophageal DNA Test performed on samples collected with its EsoCheck® Esophageal Cell Collection Device, as an acceptable alternative to invasive upper endoscopy to detect esophageal precancer.
"This update is an important step towards the recognition of the role of esophageal precancer testing to prevent esophageal cancer," said Lishan Aklog, M.D., Lucid's Chairman and Chief Executive Officer. "The NCCN Guidelines are widely recognized as a key indicator of standards of excellence for cancer care and prevention. We believe the current alignment between these highly influential cancer guidelines and multiple gastroenterology society guidelines on BE screening will help drive positive commercial insurance policy coverage decisions and expand access to EsoGuard esophageal precancer testing."
About Lucid Diagnostics
Lucid Diagnostics Inc. is a commercial-stage, cancer prevention medical diagnostics company and subsidiary of PAVmed Inc. (Nasdaq: PAVM). Lucid is focused on the millions of patients with gastroesophageal reflux disease (GERD), also known as chronic heartburn, who are at risk of developing esophageal precancer and cancer. Lucid's EsoGuard® Esophageal DNA Test, performed on samples collected in a brief, noninvasive office procedure with its EsoCheck® Esophageal Cell Collection Device, represent the first and only commercially available tools designed with the goal of preventing cancer and cancer deaths through widespread, early detection of esophageal precancer in at-risk patients.
For more information about Lucid, please visit www.luciddx.com and for more information about its parent company PAVmed, please visit www.pavmed.com.
The National Comprehensive Cancer Network® (NCCN®) is a not-for-profit alliance of 33 leading cancer centers devoted to patient care, research, and education. NCCN is dedicated to defining and advancing quality, effective, equitable, and accessible cancer care and prevention so all people can live better lives. Through the leadership and expertise of clinical professionals at NCCN Member Institutions, NCCN develops resources that present valuable information to the numerous stakeholders in the health care delivery system. By defining and advancing high-quality cancer care, NCCN promotes the importance of continuous quality improvement and recognizes the significance of creating clinical practice guidelines appropriate for use by patients, clinicians, and other health care decision-makers around the world. NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way.

Frequently Asked Questions

What is the EsoGuard Esophageal DNA Test?

The EsoGuard Esophageal DNA Test is a non-invasive test for screening esophageal precancer.

Why are NCCN Guidelines significant?

NCCN Guidelines set the standards for quality cancer care and influence treatment practices.

What does the recent update to NCCN Guidelines include?

The update includes recommendations for non-endoscopic biomarker testing for Barrett's Esophagus.

How does EsoCheck collect samples?

EsoCheck collects cell samples non-invasively in an office procedure for testing.

Who is at risk for esophageal precancer?

Patients with gastroesophageal reflux disease (GERD) are at higher risk for esophageal precancer.

Last updated: Mar 20, 2025