Full Press Release Details
Launches New Study to Determine if Certain Pre-Cancerous Cells Found in an Aging Population Can Be Eliminated by LB-100
Study in Collaboration with Netherlands Cancer Institute
in addition to LIXTE's Ongoing Clinical Trials for Ovarian and Colorectal Cancers
Calif., March 31, 2025-LIXTE Biotechnology Holdings, Inc. ("LIXTE" or the "Company") (Nasdaq:
LIXT and LIXTW), a clinical stage pharmaceutical company, today announced it will conduct a new pre-clinical study in collaboration
with Netherlands Cancer Institute (NKI) to test whether "initiated" cells that carry mutations found in cancer cells can
be eliminated by treatment with LIXTE's proprietary compound LB-100.
addition to our ongoing clinical trials in ovarian and colorectal cancer, this study represents a new opportunity in cancer prevention,"
said Bas van der Baan, LIXTE's Chief Executive Officer. "Thus far in our Phase 1 clinical trials, LB-100 has shown patient
tolerance, with little toxicity, making it a promising candidate as a broad and effective cancer prevention modality."
evidence indicates that as individuals age, certain mutations accumulate that are found in cancer cells. While these "initiated"
cells behave essentially normally, they can propagate to form reservoirs of pre-malignant cells from which malignant cells may eventually
emerge. Recent data from LIXTE's ongoing clinical collaboration with NKI shows that LB-100 activates oncogenic signaling and that
this is detrimental to cancer cells.
new study in animal models will investigate whether "initiated" cells, harboring a mutant RAS oncogene, can be eliminated
with LB-100. If successful, LB-100 could have a significant role in the elimination of initiated cells in aged individuals and could
reduce the risk of developing a wide range of cancers as a person ages.
study will be led by Ren Bernards, Ph.D., a global leader in the field of molecular carcinogenesis and Senior Staff Scientist
at NKI, one of the world's leading comprehensive cancer centers. Dr. Bernards also is a member of LIXTE's Board of Directors.
LIXTE Biotechnology Holdings, Inc.
Biotechnology Holdings, Inc. is a clinical-stage pharmaceutical company focused on new targets for cancer drug development and developing
and commercializing cancer therapies. LIXTE has demonstrated that its first-in-class lead clinical PP2A inhibitor, LB-100, is well-tolerated
in cancer patients at doses associated with anti-cancer activity. Based on extensive published preclinical data (see www.lixte.com),
LB-100 has the potential to significantly enhance chemotherapies and immunotherapies and improve outcomes for patients with cancer.
lead compound, LB-100, is part of a pioneering effort in an entirely new field of cancer biology - activation lethality -
that is advancing a new treatment paradigm. LIXTE's new approach is covered by a comprehensive patent portfolio. Proof-of-concept
clinical trials are currently in progress for colon, small cell lung and sarcoma cancers. Additional information about LIXTE can be found
Statement Disclaimer
announcement contains certain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, and Section
21E of the Securities Exchange Act of 1934. For example, statements regarding the Company's financial position, business strategy
and other plans and objectives for future operations, and assumptions and predictions about future activities, including the continuing
development of proprietary compounds, the planning, funding, coordination and potential results of clinical trials, the patent and legal
costs to protect and maintain the Company's intellectual property worldwide, and the Company's ability to obtain and maintain
compliance with Nasdaq's continued listing requirements, are all forward-looking statements. These statements are generally accompanied
by words such as "intend," anticipate," "believe," "estimate," "potential(ly),"
"continue," "forecast," "predict," "plan," "may," "will," "could,"
"would," "should," "expect" or the negative of such terms or other comparable terminology.
Company believes that the assumptions and expectations reflected in such forward-looking statements are reasonable, based on information
available to it on the date hereof, but the Company cannot provide assurances that these assumptions and expectations will prove to have
been correct or that the Company will take any action that the Company may presently be planning. However, these forward-looking statements
are inherently subject to known and unknown risks and uncertainties. Actual results or experience may differ materially from those expected
or anticipated in the forward-looking statements. Factors that could cause or contribute to such differences include, but are not limited
to, regulatory policies, available cash resources, research results, competition from other similar businesses, and market and general
are urged to read the risk factors set forth in the Company's filings with the United States Securities and Exchange Commission
at https://www.sec.gov. The Company disclaims any intention or obligation to update or revise any forward-looking statements,
whether as a result of new information, future events or otherwise.
more information about LIXTE, contact: info@lixte.com
Phone: (631) 830-7092; Investor Phone: (888) 289-5533
Inc. Investor Relations pwinvestor@pondel.com
Pondel: (310) 279-5965; Laurie Berman: (310) 279-5962