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LIXTE Biotechnology Announces $5.8 Million Registered Direct Offering Priced At-The-Market PASADENA, CA

Key Takeaway: Biotechnology Announces $5.8 Million Registered Direct Offering Priced At-The-Market CA, April 12, 2022 - LIXTE Biotechnology Holdings, Inc. (Nasdaq: LIXT), a clinical-stage drug discovery company developing pharmacologically active drugs for use in cancer treatment, today anno

Full Press Release Details

Biotechnology Announces $5.8 Million Registered Direct Offering Priced At-The-Market
CA, April 12, 2022 - LIXTE Biotechnology Holdings, Inc. (Nasdaq: LIXT), a clinical-stage drug discovery company developing pharmacologically
active drugs for use in cancer treatment, today announced that it has entered into definitive agreements for the purchase and sale of
2,900,000 shares of LIXTE's common stock, at a purchase price of $2.00 per share, in a registered direct offering. The closing
of the offering is expected to occur on or about April 14, 2022, subject to the satisfaction of customary closing conditions.
Capital, Inc. and WallachBeth Capital, LLC are acting as co-placement agents for the offering.
gross proceeds to LIXTE from this offering are expected to be approximately $5.8 million before deducting the placement agents'
fees and other offering expenses payable by LIXTE. The company intends to use the net proceeds from the offering for working capital
and general expenses including further development of its lead clinical compound LB-100.
shares of common stock are being offered by Lixte pursuant to a "shelf" registration statement on Form S-3 (File No. 333-252430)
previously filed with the Securities and Exchange Commission (the "SEC") on January 26, 2021 and declared effective by the
SEC on February 5, 2021. The offering of the securities will be made only by means of a prospectus, including a prospectus supplement,
forming a part of the effective registration statement. A final prospectus supplement and accompanying prospectus relating to the securities
being offered will be filed with the SEC. Electronic copies of the final prospectus supplement and accompanying prospectus may be obtained,
when available, on the SEC's website at http://www.sec.gov or from: WestPark Capital, Inc. - Attention: Jason Stern, 1900
Avenue of the Stars, 3rd Floor, Los Angeles, CA 90077 or by Email: syndicate@wpcapital.com or by telephone at (310) 203-2919.
press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities, nor shall there be any sale
of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration
or qualification under the securities laws of any such state or other jurisdiction.
LIXTE Biotechnology Holdings, Inc.
Biotechnology Holdings, Inc. (Nasdaq: LIXT), is a clinical-stage pharmaceutical company focused on new targets for cancer drug development
and developing and commercializing cancer therapies. Major drivers of cancer are defects in the switches that turn the biochemical pathways
in cells on or off. Most cancer research over the past 30 years has focused on the "on" switches because the "off"
switches, especially the master "off" switch protein phosphatase (PP2A), were believed to cause intolerable toxicity in patients.
LIXTE has achieved a breakthrough with its novel, first-in-class lead clinical compound and PP2A inhibitor, LB-100, demonstrating that
LB-100 is readily tolerated in cancer patients at doses associated with anti-cancer activity. Based on extensive published preclinical
data (see www.lixte.com), LB-100 has the potential to significantly improve outcomes for patients undergoing various chemotherapies
or immunotherapies. LIXTE's new approach has no known competitors and is covered by a comprehensive patent portfolio. Initial proof-of-concept
clinical trials are in progress.
announcement contains certain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, and Section
21E of the Securities Exchange Act of 1934. For example, statements regarding the Company's financial position, business strategy
and other plans and objectives for future operations, and assumptions and predictions about future product demand, supply, manufacturing,
costs, marketing and pricing factors are all forward-looking statements. These statements are generally accompanied by words such as
"intend," anticipate," "believe," "estimate," "potential(ly)," "continue,"
"forecast," "predict," "plan," "may," "will," "could," "would,"
"should," "expect" or the negative of such terms or other comparable terminology. The Company believes that the
assumptions and expectations reflected in such forward-looking statements are reasonable, based on information available to it on the
date hereof, but the Company cannot provide assurances that these assumptions and expectations will prove to have been correct or that
the Company will take any action that the Company may presently be planning. However, these forward-looking statements are inherently
subject to known and unknown risks and uncertainties. Actual results or experience may differ materially from those expected or anticipated
in the forward-looking statements. Factors that could cause or contribute to such differences include, but are not limited to, regulatory
policies, available cash, research results, competition from other similar businesses, and market and general economic factors. This
discussion should be read in conjunction with the Company's filings with the United States Securities and Exchange Commission at
General Phone: (631) 830-7092
Investor Phone: (888) 289-5533
Last updated: Apr 12, 2022