Full Press Release Details
Lexaria Studies Nitric Oxide Levels in Human Subjects
Kelowna, BC / January 13, 2016 / Lexaria, Corp. (OTCQB:LXRP)
(CSE:LXX) (the Company ) is pleased to announce it has commissioned a study of
nitric oxide levels in humans, as a biomarker for absorption of cannabidiol. The
study is expected to provide additional evidence of the efficient absorption of
cannabidiol from Lexaria food products enhanced with hemp oil, by demonstrating
the elevation of nitric oxide in the human body in response to product
The 1998 Nobel Prize in Medicine was awarded to Dr. Louis
Ignarro, Robert F. Furchgott and Ferid Murad for their discovery that nitric
oxide is a signaling molecule responsible for dilation of blood vessels. In the
heart, nitric oxide is the body s way of protecting against cardiovascular
disease, Ignarro said. The arteries make nitric oxide to lower blood pressure
and improve blood flow to organs because it is a vaso-dialator, which means it
widens or relaxes the arteries so that more blood can flow through, therefore
lowering the pressure within the arterial system. (www.news.usc.edu)
Nitric oxide levels in the body can be elevated through a
variety of dietary sources including some of the ingredients found in Lexaria
and ViPova food products. An increase in nitrate intake can augment circulating
nitrite and nitric oxide. Consumption of a nitrate-rich meal can lower systolic
blood pressure and pulse pressure and increase large artery compliance acutely
in healthy men and women. If sustained, these effects could contribute to better
cardiovascular health. (1) Lexaria believes that elevated nitric oxide levels
after the ingestion of Lexaria food products could be of great interest to the
health & wellness and fitness communities.
Another potent promoter of nitric oxide levels in the human
body is the endocannabinoid anandamide, which is augmented significantly through
administration of products that deliver bioavailable cannabidiol. In light of
this fact, Lexaria has set out to demonstrate that its cannabinoid bioabsorption
enhancing technology can augment nitric oxide levels in significant quantities.
The study is testing the effects of nitric oxide levels following ingestion of
several flavors of ViPova Tea, ViPova Coffee and Hot Chocolate, as well as
both flavors of Lexaria Energy Foods protein-energy bars. Lexaria is
specifically quantifying nitric oxide response secreted via the salivary
Beyond serving as a biomarker surrogate for cannabidiol
absorption, it is important to note that nitric oxide levels within the human
body have important implications for overall health and wellness. Elevated
levels of nitric oxide in the body have been shown to have many benefits ranging
from anti-infective properties to athletic performance and endurance enhancing
effects. Nitric oxide causes increased flow of oxygen and nutrients to tissues
and simultaneous increased removal of toxins from tissues such as lactic acid
which accumulates due to intense physical activity. Its half-life is measured
only in seconds, meaning it must be produced by the body on a regular basis in
order to be available for use.
Dietary nitrate supplementation improved endurance during
severe-intensity exercise in recreationally active subjects. (2) Therefore,
Lexaria s study findings could have numerous health applications associated with
stimulation of nitric oxide production in the human body due to the cannabidiol
absorption enhancing properties of its technology, in addition to the other
medicinal effects of cannabinoid administration in general.
Lexaria expects to conclude analysis and reporting of its study
findings shortly and will announce the outcome soon.
Nitric Oxide is a different molecule from Nitrous Oxide or from
Nitrogen Dioxide and should not be confused with either of them. Nitric Oxide is
naturally produced by most animals, including humans.
| (1) | Effects of a nitrate-rich meal on arterial stiffness and blood pressure in healthy volunteers. Liu AH , Bondonno CP , Croft KD , Puddey IB , Woodman RJ , Rich L , Ward NC , Vita JA , Hodgson JM . October 2013 | |
| (2) | Effects of nitrate on the power-duration relationship for severe-intensity exercise. Kelly J 1 , Vanhatalo A, Wilkerson DP, Wylie LJ, Jones AM. September 2013 |
Lexaria is a food sciences company focused on
the delivery of active compounds that can behave as superfoods through its
proprietary infusion technologies. Lexaria s technology enables higher
bioavailability rates for CBD; THC; NSAIDs; Nicotine and other molecules than is
possible without lipophilic enhancement technology. This can allow for lower
overall dosing requirements and/or higher effectiveness in active molecule
delivery. Lexaria hopes to reduce other common but less healthy ingestion
methods such as smoking as it embraces the benefits of public health.
legal hemp oil extracts, grown from agricultural hemp in locations where it is
legal to do so, in ViPovaTM-branded tea. ViPovaTM uses its
patent-pending process to infuse concentrated amounts of hemp oil within lipids
in its tea, providing more bioactivity and comfort to the body during the
absorption process. Only ViPovaTM has this ground-breaking technology
for hemp oil/lipid infusion. www.vipova.com
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FORWARD-LOOKING STATEMENTS
This release includes forward-looking statements. Statements
which are not historical facts are forward-looking statements. The Company makes
forward-looking public statements concerning its expected future financial
position, results of operations, cash flows, financing plans, business strategy,
products and services, competitive positions, growth opportunities, plans and
objectives of management for future operations, including statements that
include words such as "anticipate," "if," "believe," "plan," "estimate,"
"expect," "intend," "may," "could," "should," "will," and other similar
expressions are forward-looking statements, including but not limited to: the
potential industry-changing achievement as a results of the laboratory test
findings, that the in vitro findings provide compelling evidence of the
future intestinal absorption enhancing capabilities of the technology, that the
Company may become a leader in the development of potentially a wide range of
product lines with enhanced gastro-intestinal absorption performance
capabilities, that bioavailability testing in animals is likely to yield even
stronger absorption results in the presence of natural intestinal fluid
conditions, or that the technology will function in a similar manner if tested
with THC, nicotine, or any of the other molecules named in our patent
applications. Such forward-looking statements are estimates reflecting the
Company's best judgment based upon current information and involve a number of
risks and uncertainties, and there can be no assurance that other factors will
not affect the accuracy of such forward-looking statements. Access to capital,
or lack thereof, is a major risk and there is no assurance that the Company will
be able to raise required working capital. Factors which could cause actual
results to differ materially from those estimated by the Company include, but
are not limited to, government regulation, managing and maintaining growth, the
effect of adverse publicity, litigation, competition, the patent application and
approval process and other factors which may be identified from time to time in