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and Drug Administration (FDA) for ciltacabtagene autoleucel (cilta-cel) for relapsed or refractory multiple myeloma (RRMM), the submission of a marketing authorisation application (MAA) for cilta-cel to the European Medicines Agency (EMA), and
the submission of an Investigational New Drug (IND) for LB1901 in relapsed or refractory T-Cell Lymphoma (TCL); the ability to generate, analyze and present data from clinical trials; patient enrollment; anticipated timing regarding regulatory
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statements to reflect future events or circumstances. 2
Cell Therapy Platform Overview
FUTURE PIPELINE Global collaboration with Janssen for the development of cilta-cel established December
2017Received an upfront payment of $350 million and a total of $200 million in milestone payments to dateUp to an additional $1,150 million in potential future milestone payments We Are A Fully Integrated Global Cellular Therapy
Company 4 RRMM, Relapsed and/or Refractory Multiple Myeloma; AML, acute myeloid leukemia; KOL, key opinion leaders*Legal entity to the agreement is Janssen Biotech, Inc. COMPELLING DATA WITHINNOVATIVE PIPELINE GLOBAL COLLABORATION
WITH JANSSEN* INTEGRATED CELL THERAPY PLATFORM In-house antibody generation and CAR-T specific functional screening technologiesEarly clinical proof-of-concept, leveraging KOL relationships in China, the US and globallyBuilding large-scale
manufacturing facilities in the United States, Europe and China>900 employees worldwide in US, China and Europe Lead product candidate ciltacabtagene autoleucel (cilta-cel) may have the potential to deliver deep and durable anti-tumor
responses in RRMMBroad portfolio of earlier-stage autologous product candidates targeting both hematologic and solid cancers, as well as allogeneic CAR-T approaches AML LYMPHOMA GASTRIC CANCER OVARIAN CANCER INFECTIOUS DISEASE
Biotech's Global R&D Strategy 5 With a Presence in Major Geographies, our Mission is to Improve the Lives of Patients Worldwide CAR, Chimeric Antigen Receptor; TCR, T-Cell Receptor CoreTechnologies Disease Areas Product
Platforms Hematologic Malignancies CAR Autologous Allogeneic TCR Solid Tumors Infectious Diseases
End-to-End R&D Capability 6 Proprietary methodology to optimize the selection of binding domains
and design CAR-T constructs with two or more antigen-binding domains Robust in vitro and in vivo screening platforms to prioritize pipeline assets High-throughput antibody screening and engineering capability including single-domain
antibodies generated from Llama and conventional antibodies Binding Domain Selection and Construct Design Pre-clinical Validation Antibody Screening Platforms Clinical Proof of Concept Efficient clinical translation, leveraging
deep relationships with KOLs in US and China
InfectiousDiseases SolidTumors Preclinical Phase 1 Phase 2 Phase 3 Autologous TCL(CD4) AML(CD33 x
CLL-1) NHL-DLBCL(CD19 x CD20 x CD22) MM*(BCMA) Allogeneic NHL-DLBCL, FL, MCL, SLL (CD20) HIV (Undisclosed) LEGEND-2+ CARTITUDE-4 Gastric(Claudin 18.2) Ovarian (MSLN) Hematologic
Malignancies CARTIFAN-1 CARTITUDE-2 US / RoW China AML, acute myeloid leukemia; BCMA, B-cell maturation antigen; DLBCL, diffuse large B-cell lymphoma; FL, follicular lymphoma; HCC, hepatocellular carcinoma; HIV, human
immunodeficiency virus; MCL, mantle cell lymphoma; NHL, non-Hodgkin lymphomas; MM, multiple myeloma; MSLN, mesothelin; NSCLC, non small cell lung cancer; RoW, Rest of World; SCLC, small cell lung cancer; SLL, small lymphocytic lymphoma; TCL,
T-cell lymphoma*In collaboration with Janssen, Pharmaceutical Companies of Johnson & Johnson+LEGEND-2 trial is completed with ongoing follow-up MM (BCMA) Robust Pipeline of the Next Generation Cell Therapies US / China HCC,
NSCLC (Undisclosed) SCLC (Undisclosed) CARTITUDE-1 7
and Janssen Global Collaboration 8 Worldwide collaboration and license agreement to develop and commercialize cilta-cel US 50 / 50 Europe 50 / 50 Greater China 70 / 30 Legend / Janssen Japan50 / 50 Potential Additional Milestone
Paymentsup to $1,025 million Potential Additional Manufacturing Milestone Paymentsup to $125 million First Milestone$25 millionDec 2018 Fourth Milestone$30 millionJan 2020 Third Milestone$30 millionJul 2019 Second Milestone$25 millionJul
2019 Upfront Payment$350 millionQ1 2018 Fifth Milestone$75 millionDecember 2020 Sixth Milestone$15 millionMay 2021
Highly Experienced Management Team 9 CHINA US FRANK FANChief Scientific Officer &
Co-Founder ELIZABETH GOSENGlobal Manufacturing YING HUANG Chief Executive Officer/ Chief Financial Officer Lida PacaudClinical Development TRACY LUOClinical Development CHONG YANGCommercial Development SIMON WUResearch &
Development YUHONG QIUGlobal Regulatory STEVE GAVELCommercial Development ALAN KICKGlobal Quality MEETA CHATTERJEEGlobal Business Development DONG GENGEarly-stage Drug Development Lori MacomberFinance
Cilta-celClinical Development
Multiple Myeloma: Blood Cancer with a High Unmet Need 11 CI, confidence interval; PI, Proteasome
Inhibitor; IMiD, immunomodulatory drug; MM, multiple myeloma; OS, overall survival 1. Cancer Stat Facts: Myeloma. https://seer.cancer.gov/statfacts/html/mulmy.html. Accessed June 2021. 2. Facts and Statistics.
https://www.lls.org/facts-and-statistics/facts-and-statistics-overview. Accessed June 2021. 3. Globocan 2020 World Fact Sheet: https://gco.iarc.fr/today/data/factsheets/cancers/35-Multiple-myeloma-fact-sheet.pdf. Accessed June 2021. 4. Globocan
2020 World Fact Sheet: World. https://gco.iarc.fr/today/data/factsheets/populations/900-world-fact-sheets.pdf. Accessed June 2021. 5. Globocan 2020 World Fact Sheet: United States of America.
http://gco.iarc.fr/today/data/factsheets/populations/840-united-states-of-america-fact-sheets.pdf. Accessed June 2021. 6. Globocan 2020 World Fact Sheet: Europe. https://gco.iarc.fr/today/data/factsheets/populations/908-europe-fact-sheets.pdf.
Accessed June 2021. 7. Globocan 2020 World Fact Sheet: China. https://gco.iarc.fr/today/data/factsheets/populations/160-china-fact-sheets.pdf. Accessed June 2021. 8. Gandhi UH, et al. Leukemia. 2019;33:2266-75. US: Incidence is 32,119,
with mortality of 13,4265 EUROPE: Incidence is 50,918, with mortality of 32,4956 CHINA: Incidence is 21,116, with mortality of 16,1827 176,404 NEW CASES WORLDWIDE IN 2020,accounting for 1% of worldwidenew cancer
cases3,4 1.0 0.8 0.6 0.4 0.2 0.0 0 10 20 30 40 50 Months Proportion
Surviving Non-triple-refractory (N=57) Triple-and quad-refractory (N=148) Penta-refractory (N=70) P=0.002 POOR SURVIVAL OUTCOMES IN MULTIPLE REFRACTORY MMMedian OS < 12
months 3RD MOST COMMON BLOOD CANCER
accounting for 18% of all hematologic cancer1-3 in patients refractory to anti-CD38, 1 PI(s) and / or 1 IMiD(s)8 Median OS for each group Median OS(months) 95% Cl Non-triple-refractory 11.2 (5.4-17.1) Triple-and
quad-refractory 9.2 (7.1-11.2) Penta-refractory 5.6 (3.5-7.8)
First-in-Human, Phase 1, Dose Finding Study in RRMM LEGEND-2: LCAR-B38M CAR-T
cells 12 Shanghai Jiangsu Province Hospital2 Chen, ASH 2019 Poster Nanjing Second Affiliated Hospital of Xi'an Jiaotong University1 Wang et al, ASH 2019 Oral
Presentation Xi'an Data cut-off: 31 July 2019 (N=57) and 31 October 2019 (N=17);1. Wang B-Y et al. ASH Annual Meeting; December 7-10, 2019; Orlando, FL, Abstract 579. 2. Chen L, et al. ASH Annual Meeting; December 7-10, 2019; Orlando, FL,
Abstract 1858. Shanghai Ruijin Hospital2Chen, ASH 2019 Poster Shanghai Changzheng Hospital2Chen, ASH 2019 Poster Xi'an Nanjing Shanghai Enrollment Total: 74 patients (4 sites in China) Xi'an: N=57, Wang, et al. ASH
2019JS/RJ/CZ sites: N=17, Chen, et al. ASH 2019 Active MM defined by IMWG criteria with documented disease progression during or within 12 months of most recent anti-MM drugs or auto-HSCTRelapsed on prior regimens Key Inclusion
Criteria1,2 Administered dose (CAR+ viable T cells/kg) Xi'an1 (median)=0.5x106 (0.07-2.1x106)RJ/CZ/JS2 (mean)=0.70x106 (0.2-1.5x106) Preconditioning Cyclophosphamide only (Xi'an, Jiangsu)1,2Cyclophosphamide + fludarabine (Changzheng,
Ruijin)2 Safety & Tolerability Cilta-cel CAR-T cells displayed a safety profile consistent with other safety reports of BCMA-targeting CAR-T cell therapy1,2
LEGEND-2: Long-Term Deep Responses and High Response Rate 13 ORRa =
88% 74%(n=42) 4%(n=2) 11%(n=6) 9%(n=5) 2%(n=1) 2%(n=1) 82%(n=14) 6%(n=1) 12%(n=2) Xi'an: Best overall response (N=57)1 ORRa = 88% Median time to initial response= 1 month2mPFS = 18 months; mOS= not reached2 mDOR= 27.0 months (mDOR
for CR= 29.1 months)1Median time to initial response= 1 month1mPFS= 19.9 months (mPFS for CR= 28.2 months)1 mOS = 36.1 months (mOS for CR not reached)1 Ruijin (RJ), Jiangsu (JS), Changzheng (CZ): Best overall response (N=17)2 Median
follow-up 25 months Median follow-up 26 months Data cut-off: 31 July 2019 (N=57) and 31 October 2019 (N=17); Xi'an: NE patient died of PE/ACS prior to first evaluation. RJ,JS, CZ: For NE patients, 1 patient died on Day 13 due to CRS and
tumor lysis syndrome; 1 patient received chemotherapy prior to first assessment and was censored. a ORR=PR or better; response assessed per International Myeloma Working Group criteriaCR, complete response; VGPR, very good partial response; PR,
partial response; SD, stable disease; PD, progressive disease; NE, not evaluable; mDOR, median duration of response; MRD, minimal residual disease; ORR, overall response rate; mPFS, median progression free survival; mOS, median overall
survival.1. Wang B-Y et al. ASH Annual Meeting; December 7-10, 2019; Orlando, FL, Abstract 579; 2. Chen L, et al. ASH Annual Meeting; December 7-10, 2019; Orlando, FL, Abstract 1858.
Post-infusion AssessmentsSafety, Efficacy, PK, PD, Biomarker Screening (28 Days) Apheresis Bridging
Therapya (as needed) Cy (300 mg/m2) + Flu (30 mg/m2) Cilta-cel InfusionTarget: 0.75x106 (0.5 - 1.0x106) CAR+ viable T cells/kg Follow-up CARTITUDE-1: Phase 1b/2 Study Design 14 14 Day -5 to -3 Day
1 Primary Objectives Key Inclusion Criteria Administered dose Median administered dose: 0.71x106 (0.51- 0.95x106) CAR+ viable T cells/kg Progressive MM per IMWG criteriaECOG PS 1 Measurable diseaseReceived 3 prior therapies or double
refractoryPrior PI, IMiD, anti-CD38 therapy Phase 1b: Characterize the safety of ciltacabtagene autoleucel (cilta-cel) and confirm the recommended phase 2 dosePhase 2: Evaluate the efficacy of cilta-cel by ORR Cy, cyclophosphamide;
ECOG PS, Eastern Cooperative Oncology Group performance status; Flu, fludarabine; IMiD, immunomodulatory drug; IMWG, International Myeloma Working Group; PI, proteasome inhibitor; PD, pharmacodynamic; PK, pharmacokinetic; MM, multiple
myelomaData cut-off: Feb 11, 2021; a Treatment that was received previously and resulted in at least stable disease.1. Usmani S, et al. ASCO Annual Meeting (Virtual). June 4-8, 2021. Abstract 8005; 2. Clinicaltrials.gov website (NCT03548207).
https://clinicaltrials.gov/ct2/show/NCT03548207. Accessed June 2021
15 CARTITUDE-1: Baseline Characteristics Characteristic (N=97) Age, median (range) years 61.0
(43-78) Male, n (%) 57 (58.8) Black/African American, n (%) 17 (17.5) All plasmacytomas,a n (%) 19 (19.6) Extramedullary plasmacytomas, n (%) 13 (13.4) Bone-based plasmacytomas, n (%) 6 (6.2) Bone-marrow plasma cells 60%, n (%) 21
(21.9) Years since diagnosis, median (range) 5.9 (1.6-18.2) High-risk cytogenetic profile, n (%) 23 (23.7) del17p 19 (19.6) t(14;16) 2 (2.1) t(4;14) 3 (3.1) Tumor BCMA expression 50%, n (%) 57 (91.9)b Characteristic Prior lines
of therapy, median (range) 6.0 (3-18) Prior lines of therapy, n (%) 3 17 (17.5) 4 16 (16.5) 5 64 (66.0) Previous stem-cell transplantation, n (%) Autologous 87 (89.7) Allogeneic 8 (8.2) Triple-class exposed,c n (%) 97
(100) Penta-drug exposed,d n (%) 81 (83.5) Triple-class refractoryc 85 (87.6) Penta-drug refractoryd 41 (42.3) Refractory status, n (%) Carfilzomib 63 (64.9) Pomalidomide 81 (83.5) Anti-CD38 antibody 96 (99.0) Refractory to
last line of therapy, n (%) 96 (99.0) Data cut-off: Feb 11, 2021; BCMA, B-cell maturation antigen; IMiD, immunomodulatory drug; PI, proteasome inhibitor.aAll plasmacytomas include extramedullary and bone-based plasmacytomas. bDenominator
n=62, the number of evaluable samples; BCMA expression detected in all evaluable samples. cAt least 1 PI, at least 1 IMiD, and 1 anti-CD38 antibody. dAt least 2 PIs, at least 2 IMiDs, and 1 anti-CD38 antibody. Usmani S, et al. ASCO Annual
Meeting (Virtual). June 4-8, 2021. Abstract 8005
CARTITUDE-1: Overall Response Rate Data cut-off: Feb 11, 2021; CR, complete response; MRD, minimal
residual disease; ORR, overall response rate; sCR, stringent complete response; VGPR, very good partial response. ORR assessed by independent review committee. aSubgroups by number of prior lines of therapy ( 4, >4), refractoriness
(triple-class, penta-drug), cytogenetic risk (high risk, standard risk), baseline bone marrow plasma cells ( 30%, >30 to <60%, 60%), baseline tumor BCMA expression ( median, <median), and baseline plasmacytomas (including
extramedullary and bone-based). bMRD was assessed in evaluable samples (ie, patients with identifiable clone at baseline and sufficient cells for testing at 10-5 threshold in post treatment samples) by next-generation sequencing (clonoSEQ,
Adaptive Biotechnologies) in all treated patients at Day 28, and at 6, 12, 18, and 24 months regardless of the status of disease measured in blood or urine. Usmani S, et al. ASCO Annual Meeting (Virtual). June 4-8, 2021. Abstract 8005 Median
time to first response: 1 month (range, 0.9-10.7)Median duration of response: 21.8 months (95% CI, 21.8-NE); not reached in patients with sCRResponse rates were comparable (range, 95-100%) across different subgroups (eg, number of prior lines
of therapy, refractoriness, extramedullary plasmacytomas, and cytogenetic risk)a91.8% of 61 evaluable patients were MRD negativebMedian time to MRD 10-5 negativity: 1 month (range, 0.8-7.7) N=97 80.4%sCR 94.8% VGPR With longer follow-up,
responses deepened with increasing rate of sCR 16
CARTITUDE-1: Progression Free Survival 17 Progression-Free Survival, Patients
Patients sCR Median: 22.8 months (95% CI, 22.8-NE) Median: not reached 18-month PFS:All Patients: 66.0% (95% CI, 54.9-75.0)sCR: 75.9% (95% CI, 63.6-84.5)18-month OS:All patients: 80.9% (95% CI,
71.4-87.6) 97 95 85 77 73 55 26 9 1 1 0 78 78 76 71 68 51 26 9 1 1 0 All Patients Responders With sCR Number at Risk Data cut-off: Feb 11, 2021; NE, not estimable; PFS, progression-free survival; OS, overall survival;
sCR, stringent complete response.Usmani S, et al. ASCO Annual Meeting (Virtual). June 4-8, 2021. Abstract 8005 Median duration of follow-up: 18 months (range, 1.5-30.5)
18 CARTITUDE-1: Safety Data cut-off: Feb 11, 2021; AE, adverse event; ALT, alanine aminotransferase;