LINEAGE CELL THERAPEUTICS REPORTs SECOND QUARTER 2023 FINANCIAL RESULTS AND PROVIDES BUSINESS UPDATE Enrollment Continues in Phase 2a Clinical Study of RG6501 (OpRegen ) in Patients with GA Secondary to AMD Under Managem

CELL THERAPEUTICS REPORTs SECOND QUARTER 2023 FINANCIAL

RESULTS AND PROVIDES BUSINESS UPDATE

CA - August 10, 2023 - Lineage Cell Therapeutics, Inc. (NYSE American and TASE: LCTX), a clinical-stage biotechnology

company developing allogeneic cell therapies for unmet medical needs, today reported financial and operating results for the second quarter

ended June 30, 2023 and will host a conference call today at 4:30 p.m. Eastern Time to discuss these results.

Lineage team continued to execute across multiple fronts during the second quarter, advancing our clinical and preclinical cell transplant

programs and supporting our valuable alliances," stated Brian M. Culley, Lineage CEO. "The most important area of attention

was our partnership with Roche and Genentech and continued support for the ongoing Phase 2a clinical study of OpRegen in patients with

GA secondary to AMD, which has been enrolling patients from multiple sites in the U.S. Through presentations at medical and scientific

conferences, we also sought to increase awareness of OpRegen's potential to provide durable anatomical and functional improvements

to patients with advanced dry AMD. In partnership with CIRM and the Christopher & Dana Reeve Foundation, we created and presented

the 1st Annual Spinal Cord Injury Investor Symposium, which brought together stakeholders to share expertise on spinal cord

injury and reflects the receipt of a new and clarified path we obtained from FDA for an IND amendment for our OPC1 program.

We also reported positive clinical results from a Phase 1 study of VAC2 in non-small cell lung cancer alongside our partner, Cancer Research

UK. Looking ahead, we will continue to focus on making progress across our pipeline while maintaining our rigorous commitment

to disciplined spending. Overall, we believe the use of differentiated allogeneic cell transplants can provide a meaningful impact for

patients and are encouraged by the progress we and others have made in this field."

milestones and activities included:

cash equivalents, and marketable securities totaled $45.9 million as of June 30, 2023, which is expected to support planned operations

Quarter Operating Results

Lineage's revenue is generated primarily from licensing fees, royalties, collaboration revenues, and research grants. Total revenues

for the three months ended June 30, 2023 were $3.2 million, a net decrease of $1.4 million as compared to approximately $4.6 million

for the same period in 2022. The decrease was primarily driven by less collaboration and licensing revenue recognized from deferred revenues

from the Roche Agreement.

Expenses: Operating expenses are comprised of research and development ("R&D") expenses and general and administrative

("G&A") expenses. Total operating expenses for the three months ended June 30, 2023 were $8.1 million, a decrease of

$0.5 million as compared to $8.6 million for the same period in 2022.

Expenses: R&D expenses for the three months ended June 30, 2023 were $3.9 million, a net increase of $0.6 million as compared

to $3.3 million for the same period in 2022. The net increase was primarily driven by $0.4 million in higher OpRegen program-related

expenses, and $0.3 million in non-clinical-related expenses to support the OPC1 program.

Expenses: G&A expenses for the three months ended June 30, 2023 were $4.2 million, a net decrease of approximately $1.1 million

as compared to $5.3 million for the same period in 2022. The decrease was primarily driven by $0.5 million in lower litigation and legal

expenses, and an overall reduction in costs incurred for services by third parties, consulting costs, and stock-based compensation expense.

from Operations: Loss from operations for the three months ended June 30, 2023 was $5.0 million, an increase of $0.8 million as compared

to $4.2 million for the same period in 2022.

Income/(Expenses), Net: Other income (expenses), net for the three months ended June 30, 2023 reflected other expense, net of ($0.2)

million, compared to other expense, net of ($2.5) million for the same period in 2022. The net change was primarily driven by exchange

rate fluctuations related to Lineage's international subsidiaries, fair market value changes in marketable equity securities, and

interest income from our marketable debt securities.

Loss Attributable to Lineage: The net loss attributable to Lineage for the three months ended June 30, 2023 was $5.2 million, or

$0.03 per share (basic and diluted), compared to a net loss attributable to Lineage of $6.8 million, or $0.04 per share (basic and diluted),

for the same period in 2022.

parties may access today's conference call and webcast, by dialing (800) 715-9871 from the U.S. and Canada and should request the

"Lineage Cell Therapeutics Call". A live webcast of the conference call will be available online in the Investors

section of Lineage's website. A replay of the webcast will be available on Lineage's website for 30 days and a telephone

replay will be available through August 17, 2023, by dialing (800) 770-2030 from the U.S. and Canada and entering conference ID number

Lineage Cell Therapeutics, Inc.

Cell Therapeutics is a clinical-stage biotechnology company developing novel cell therapies for unmet medical needs. Lineage's

programs are based on its robust proprietary cell-based therapy platform and associated in-house development and manufacturing capabilities.

With this platform Lineage develops and manufactures specialized, terminally differentiated human cells from its pluripotent and progenitor

cell starting materials. These differentiated cells are developed to either replace or support cells that are dysfunctional or absent

due to degenerative disease or traumatic injury or administered as a means of helping the body mount an effective immune response to

cancer. Lineage's clinical and preclinical programs are in markets with billion dollar opportunities and include five allogeneic

("off-the-shelf") product candidates: (i) OpRegen, a retinal pigment epithelial cell therapy in Phase 2a development for

the treatment of geographic atrophy secondary to age-related macular degeneration, is being developed under a worldwide collaboration

with Roche and Genentech, a member of the Roche Group; (ii) OPC1, an oligodendrocyte progenitor cell therapy in Phase 1/2a development

for the treatment of acute spinal cord injuries; (iii) VAC2, a dendritic cell therapy produced from Lineage's VAC technology platform

for immuno-oncology and infectious disease, currently in Phase 1 clinical development for the treatment of non-small cell lung cancer;

(iv) ANP1, an auditory neuronal progenitor cell therapy for the potential treatment of auditory neuropathy; and (v) PNC1, a photoreceptor

neural cell therapy for the potential treatment of vision loss due to photoreceptor dysfunction or damage. For more information, please

visit www.lineagecell.com or follow the company on Twitter @LineageCell.

cautions you that all statements, other than statements of historical facts, contained in this press release, are forward-looking statements.

Forward-looking statements, in some cases, can be identified by terms such as "believe," "aim," "may,"

"will," "estimate," "continue," "anticipate," "design," "intend,"

"expect," "could," "can," "plan," "potential," "predict," "seek,"

"should," "would," "contemplate," "project," "target," "tend to,"

or the negative version of these words and similar expressions. Such statements include, but are not limited to, statements relating

to: the significance of the Phase 2a clinical study of OpRegen and the expansion of the study to additional clinical sites; that our

cash, cash equivalents and marketable securities is sufficient to support our planned operations into the fourth quarter of 2024; plans

and expectations regarding publications and presentations related to our programs, the timing of anticipated regulatory submissions to

the FDA related to our programs, including OPC1, the potential future achievements of our clinical, preclinical and development programs,

the initiation of clinical trials and the availability of clinical data updates related to our programs; plans and expectations regarding

existing collaborations; the effect of the SCIIS, including increasing disease awareness, the probability of success in product development,

and clinical trial participation; the potential effects of being added to the Russel 3000 Index; our ability to broaden awareness of

our mission, programs and accomplishments; and the potential of our cell therapy platform and our ability to provide an meaningful impact

for patients. Forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause Lineage's

actual results, performance or achievements to be materially different from future results, performance or achievements expressed or

implied by the forward-looking statements in this press release, including, but not limited to, the following risks: that we may need

to allocate our cash to unexpected events and expenses causing us to use our cash, cash equivalents and marketable securities more quickly

than expected; that positive findings in early clinical and/or nonclinical studies of a product candidate may not be predictive of success

in subsequent clinical and/or nonclinical studies of that candidate; that OpRegen may never be proven to provide durable anatomical functional

improvements in dry-AMD patients, that competing alternative therapies may adversely impact the commercial potential of OpRegen; that

Roche and Genentech may not successfully advance OpRegen or be successful in completing further clinical trials for OpRegen and/or obtaining

regulatory approval for OpRegen in any particular jurisdiction; that the feedback received from the FDA for OPC1 may not enable further

clinical development; that Lineage may not be able to manufacture sufficient clinical quantities of its product candidates in accordance

with current good manufacturing practice; and those risks and uncertainties inherent in Lineage's business and other risks discussed

in Lineage's filings with the Securities and Exchange Commission (SEC). Lineage's forward-looking statements are based upon

its current expectations and involve assumptions that may never materialize or may prove to be incorrect. All forward-looking statements

are expressly qualified in their entirety by these cautionary statements. Further information regarding these and other risks is included

under the heading "Risk Factors" in Lineage's periodic reports with the SEC, including Lineage's most recent

Annual Report on Form 10-K filed with the SEC and its other reports, which are available from the SEC's website. You are cautioned

not to place undue reliance on forward-looking statements, which speak only as of the date on which they were made. Lineage undertakes

no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made,

except as required by law.

Cell Therapeutics, Inc. IR

(ir@lineagecell.com)

(daniel@lifesciadvisors.com)