LINEAGE CELL THERAPEUTICS REPORTs FIRST QUARTER 2022 FINANCIAL RESULTS AND PROVIDES BUSINESS UPDATE Reported RG6501 (OpRegen ) Clinical Results at 2022 ARVO Meeting; Outer Retinal Structure Improvement Observed in Five D

CELL THERAPEUTICS REPORTs FIRST QUARTER 2022 FINANCIAL RESULTS AND PROVIDES BUSINESS UPDATE

CA - May 12, 2022 - Lineage Cell Therapeutics, Inc. (NYSE American and TASE: LCTX), a clinical-stage biotechnology company

developing allogeneic cell therapies for unmet medical needs, today reported financial and operating results for the first quarter of

2022. Lineage management will host a conference call and webcast today at 4:30 p.m. Eastern Time/1:30 p.m. Pacific Time to discuss its

first quarter 2022 financial and operating results and to provide a business update.

first quarter of this year was highlighted by the rapid launch of new cell therapy programs in hearing loss and vision disorders and

conducting tech transfer activities to support our alliance with Roche and Genentech for our dry AMD program," stated Brian M.

Culley, Lineage CEO. "Our broad strategic plan is to position Lineage as a leader in regenerative medicine through the transplant

of specific cell types to treat significant unmet medical needs. As part of that plan, we have expanded our cell therapy pipeline to

five distinct programs, each offering an opportunity to impact various diseases. We believe our ability to, in just a matter of months,

advance from a product concept to generating new intellectual property to support the manufacture of specific cell types, is not only

illustrative of the power and efficiency of our platform but also a competitive advantage compared to others in this field. Looking forward,

our focus is on clinical and regulatory execution across our portfolio. We are working to advance OPC1 and VAC2 into their next phases

of clinical testing, in spinal cord injury and oncology, respectively, as well as advancing our auditory neuron and photoreceptor programs

through preclinical development and toward pre-IND meetings with FDA. We believe the combination of our disciplined use of capital and

current balance sheet will support multiple years of progress, during which we anticipate reaching significant events with each of our

clinical and preclinical programs."

of the events and milestones anticipated by Lineage in the rest of 2022 include:

and cash equivalents totaled $78.1 million as of March 31, 2022.

Quarter Operating Results

Lineage's revenue is generated primarily from research grants, royalties, and licensing fees. Total revenues for the three months

ended March 31, 2022 were $5.2 million, an increase of $4.8 million as compared to $0.4 million for the same period in 2021. The increase

was primarily related to licensing fees recognized from deferred revenues in connection with the $50.0 million upfront licensing payment

received in the first quarter of 2022 from Roche.

Expenses: Operating expenses are comprised of research and development ("R&D") expenses and general and administrative

("G&A") expenses. Total operating expenses for the three months ended March 31, 2022 were $11.5 million, an increase

of $4.2 million as compared to $7.3 million for the same period in 2021, primarily attributable to a $3.5 million non-recurring expense

related to the potential settlement of the litigation concerning our 2019 acquisition of Asterias ("Asterias Litigation").

Expenses: R&D expenses for the three months ended March 31, 2022 were $3.0 million, a decrease of $0.4 million as compared to

$3.4 million for the same period in 2021. The decrease was driven by $0.7 million in lower expenses for the OPC1 program, partially offset

by $0.2 million and $0.1 million in higher expenses to support the VAC program and OpRegen related expenses to support the Roche Collaboration,

respectively. Another $0.1 million of the offsetting increase was related to initial costs to support the new auditory neuron cell therapy

Expenses: G&A expenses for the three months ended March 31, 2022 were $8.5 million, an increase of $4.6 million as compared to

$3.9 million for the same period in 2021. The increase was primarily attributable to the $3.5 million non-recurring expense related to

the potential settlement of the Asterias Litigation, and $0.5 million in share-based compensation.

from Operations: Loss from operations for the three months ended March 31, 2022 was $6.4 million, a decrease of $0.7 million as compared

to $7.1 million for the same period in 2021.

Income/(Expenses), Net: Other income (expenses), net for the three months ended March 31, 2022 reflected other expense, net of ($0.7)

million, compared to other income, net of $5.6 million for the same period in 2021. The net change of ($6.3) million was primarily related

to the gain on sale of marketable securities in the prior year.

Loss Attributable to Lineage: The net loss attributable to Lineage for the three months ended March 31, 2022 was $7.1 million, or

$0.04 per share (basic and diluted), compared to a net loss attributable to Lineage of $1.4 million, or $0.01 per share (basic and diluted),

for the same period in 2021.

parties may access today's conference call by dialing (866) 888-8633 from the U.S. and Canada and (636) 812-6629 from elsewhere

outside the U.S. and Canada and should request the "Lineage Cell Therapeutics Call". A live webcast of the conference call

will be available online in the Investors section of Lineage's website. A replay of the webcast will be available on Lineage's

website for 30 days and a telephone replay will be available through May 20, 2022, by dialing (855) 859-2056 from the U.S. and Canada

and (404) 537-3406 from elsewhere outside the U.S. and Canada and entering conference ID number 1875641.

Lineage Cell Therapeutics, Inc.

Cell Therapeutics is a clinical-stage biotechnology company developing novel cell therapies for unmet medical needs. Lineage's

programs are based on its robust proprietary cell-based therapy platform and associated in-house development and manufacturing capabilities.

With this platform Lineage develops and manufactures specialized, terminally differentiated human cells from its pluripotent and progenitor

cell starting materials. These differentiated cells are developed to either replace or support cells that are dysfunctional or absent

due to degenerative disease or traumatic injury or administered as a means of helping the body mount an effective immune response to

cancer. Lineage's clinical programs are in markets with billion dollar opportunities and include five allogeneic ("off-the-shelf")

product candidates: (i) OpRegen, a retinal pigment epithelial cell therapy in Phase 1/2a development for the treatment of geographic

atrophy secondary to age-related macular degeneration, which is being developed under a worldwide collaboration with Roche and

Genentech, a member of the Roche Group; (ii) OPC1, an oligodendrocyte progenitor cell therapy in Phase 1/2a development for the treatment

of acute spinal cord injuries; (iii) VAC2, a dendritic cell therapy produced from Lineage's VAC technology platform for immuno-oncology

and infectious disease, currently in Phase 1 clinical development for the treatment of non-small cell lung cancer; (iv) ANP1, an auditory

neuronal progenitor cell therapy for the potential treatment of auditory neuropathy; and (v) PNC1, a photoreceptor neural cell therapy

for the treatment of vision loss due to photoreceptor dysfunction or damage. For more information, please visit www.lineagecell.com

or follow the company on Twitter @LineageCell.

cautions you that all statements, other than statements of historical facts, contained in this press release, are forward-looking statements.

Forward-looking statements, in some cases, can be identified by terms such as "believe," "aim," "may,"

"will," "estimate," "continue," "anticipate," "design," "intend,"

"expect," "could," "can," "plan," "potential," "predict," "seek,"

"should," "would," "contemplate," "project," "target," "tend to,"

or the negative version of these words and similar expressions. Such statements include, but are not limited to, statements relating

to: the collaboration and license agreement with Roche and Genentech, activities expected to occur thereunder, the potential to receive

upfront, milestone and royalty consideration payable to Lineage thereunder; the potential benefits of treatment with OpRegen; the power

and efficiency of Lineage's platform and its competitive advantages; the ability of Lineage's resources to support multiple

years of progress; the potential future achievements of Lineage's clinical and preclinical programs; the timing of potential FDA

interactions, and of anticipated clinical trials and clinical data updates; and plans and expectations of Lineage's products in

development. Forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause Lineage's

actual results, performance or achievements to be materially different from future results, performance or achievements expressed or

implied by the forward-looking statements in this press release, including, but not limited to, the risk that positive findings in early

clinical and/or nonclinical studies of a product candidate may not be predictive of success in subsequent clinical and/or nonclinical

studies of that candidate; the risk that competing alternative therapies may adversely impact the commercial potential of OpRegen; the

risk that Roche and Genentech may not be successful in completing further clinical trials for OpRegen and/or obtaining regulatory approval

for OpRegen in any particular jurisdiction; the risk that Lineage may not be able to manufacture sufficient clinical quantities of its

product candidates in accordance with current good manufacturing practice; risks and uncertainties inherent in Lineage's business

and other risks discussed in Lineage's filings with the Securities and Exchange Commission (SEC). Lineage's forward-looking

statements are based upon its current expectations and involve assumptions that may never materialize or may prove to be incorrect. All

forward-looking statements are expressly qualified in their entirety by these cautionary statements. Further information regarding these

and other risks is included under the heading "Risk Factors" in Lineage's periodic reports with the SEC, including

Lineage's most recent Annual Report on Form 10-K and Quarterly Report on Form 10-Q filed with the SEC and its other reports, which

are available from the SEC's website. You are cautioned not to place undue reliance on forward-looking statements, which speak

only as of the date on which they were made. Lineage undertakes no obligation to update such statements to reflect events that occur

or circumstances that exist after the date on which they were made, except as required by law.

Cell Therapeutics, Inc. IR

(ir@lineagecell.com)

(jfrantz@soleburytrout.com

Partners - Media Relations

Johnson or David Schull