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BIOTIME TO PRESENT SCiSTAR CLINICAL STUDY TOP-LINE DATA AT THE 26

Key Takeaway: TO PRESENT SCiSTAR CLINICAL STUDY TOP-LINE DATA AT THE 26TH ANNUAL AMERICAN SOCIETY FOR NEURAL THERAPY AND REPAIR CONFERENCE CA - April 26, 2019 - BioTime, Inc. (NYSE American and TASE: BTX), a clinical-stage biotechnology company developing new cellular therapies, announced to

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TO PRESENT SCiSTAR CLINICAL STUDY TOP-LINE DATA AT THE 26TH ANNUAL AMERICAN SOCIETY FOR NEURAL THERAPY AND REPAIR CONFERENCE
CA - April 26, 2019 - BioTime, Inc. (NYSE American and TASE: BTX), a clinical-stage biotechnology
company developing new cellular therapies, announced today that Edward D. Wirth, III, M.D., Ph.D., Chief Medical Officer of BioTime,
will present at the 26th Annual American Society for Neural Therapy and Repair (ASNTR) Annual Conference on
April 26th, 2019 at 10:30am EDT part of Session 6: "Spinal Cord Injury". Dr. Wirth's presentation
is entitled "Top-line 12-month Results from the SCiStar Study - A Phase 1/2a Trial of Human Embryonic Stem Cell-Derived
Oligodendrocyte Progenitor Cells (OPC1) in Patients with Subacute Cervical Spinal Cord Injury". ASNTR will be held April
25 - 27, 2019 at the Sheraton Sand Key Resort in Clearwater Beach, Florida.
believe the primary goals of the SCiStar Study, which were to observe the safety of OPC1 in cervical spinal cord injury patients
as well as other important metrics including related to the optimal timing of OPC1 injection, tolerability of the immunosuppression
regimen, engraftment of OPC1 cells, and rates of motor recovery observed among different study subpopulations, have all been successfully
achieved," stated Dr. Wirth. "We now
are in the process of analyzing the full data set from the SCiStar Study to inform how best to proceed with this promising program.
We expect to propose a clinical plan to the U.S. Food and Drug Administration later this year and expect to share the outcome
of those discussions when they are available."
appreciate the support of the California Institute for Regenerative Medicine, the
world's largest institution dedicated to bringing the future of cellular medicine closer to reality, whose generous grant
funding to date of $14.3 million has helped advance the clinical development of our OPC1 program and generate these encouraging
clinical results in patients with traumatic spinal cord injuries," stated Brian M. Culley, Chief Executive Officer of BioTime.
"We look forward to continuing our partnership with CIRM and will support their mission to accelerate stem cell treatments
to patients with unmet medical needs and fast-track the development of the most promising stem cell technologies."
SCiStar Study is an open-label, single-arm trial testing three sequential escalating doses of OPC1 administered 21 to 42
days post-injury, at up to 20 million OPC1 cells in 25 subjects with subacute motor complete (AIS-A or AIS-B) cervical (C-4 to
C-7) acute spinal cord injuries (SCI). These individuals have essentially lost all movement below their injury site and experience
severe paralysis of the upper and lower limbs. AIS-A subjects have lost all motor and sensory function below their injury site,
while AIS-B subjects have lost all motor function but may have retained some minimal sensory function below their injury site.
The primary endpoint in the SCiStar study was safety as assessed by the frequency and severity
of adverse events related to OPC1, the injection procedure, and immunosuppression with short-term, low-dose tacrolimus. Secondary
outcome measures included neurological functions as measured by upper extremity motor scores and motor level on International
Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) examinations at 30, 60, 90, 180, 270, and 365 days after
are a summary of key findings from the SCiStar Study. A copy of Dr. Wirth's presentation will be available on the Events
section of BioTime's website concurrent with his presentation at ASNTR.
Magnetic resonance imaging (MRI) scans at 12 months post-injection of OPC1 has shown no evidence of adverse changes in any of the 25 SCiStar study subjects treated with OPC1.
To date, there have been no unexpected serious adverse events (SAEs) related to the OPC1 cells.
No concerning safety issues and no intraoperative complications have been noted
No SCiStar study subjects had worsening of neurological function post-injection
No adverse findings observed on follow-up MRI scans
Immunosuppression with tacrolimus ( an immunosuppressive drug utilized mainly after allogeneic organ transplant to lower the risk of organ rejection) was well-tolerated
Three subjects (Cohort 1) received a sub-therapeutic dose of 2M cells to evaluate the initial safety of injecting OPC1 into lesions in the cervical spinal cord. All other subjects (Cohorts 2-5) received 10M or 20M cells.
At 12 months, 95% (21/22) of SCiStar study subjects in Cohorts 2-5 recovered at least one motor level on at least one side and 32% (7/22) of these subjects recovered two or more motor levels on at least one side. The average improvement in upper extremity motor score as measured by the ISNCSCI scale for these subjects was 8.9 points.
Notably, no SCiStar study subjects saw decreased motor function following administration of OPC1 and subjects either retained for 12 months the motor function recovery seen through 6 months or experienced further motor function recovery from 6 to 12 months.
is an oligodendrocyte progenitor cell (OPC) therapy currently being tested in a Phase I/IIa clinical trial known as SCiStar for
the treatment of acute spinal cord injuries. OPCs are naturally-occurring precursors to the cells which provide electrical insulation
for nerve axons in the form of a myelin sheath. SCI occurs when the spinal cord is subjected to a severe crush or contusion injury
and typically results in severe functional impairment, including limb paralysis, aberrant pain signaling, and loss of bladder
control and other body functions. The clinical development of the OPC1 program has been
partially funded by a $14.3 million grant from the California Institute for Regenerative Medicine. OPC1 has received Regenerative
Medicine Advanced Therapy (RMAT) designation for the treatment of acute SCI and has been granted Orphan Drug designation from
the U.S. Food and Drug Administration (FDA).
is a clinical-stage biotechnology company developing new cellular therapies for degenerative retinal diseases, neurological conditions
associated with demyelination, and aiding the body in detecting and combating cancer. BioTime's programs are based on its
proprietary cell-based therapy platform and associated development and manufacturing capabilities. With this platform BioTime
develops and manufactures specialized, terminally-differentiated human cells from its pluripotent and progenitor cell starting
materials. These differentiated cells are developed either to replace or support cells that are dysfunctional or absent due to
degenerative disease or traumatic injury, or administered as a means of helping the body mount an effective immune response to
cancer. BioTime's clinical assets include (i) OpRegen , a retinal pigment epithelium transplant therapy in
Phase I/IIa development for the treatment of dry age-related macular degeneration, the leading cause of blindness in the developed
world; (ii) OPC1, an oligodendrocyte progenitor cell therapy in Phase I/IIa development for the treatment of acute spinal cord
injuries; and (iii) VAC2, an allogeneic cancer immunotherapy of antigen-presenting dendritic cells currently in Phase I development
for the treatment of non-small cell lung cancer. For more information, please visit www.biotimeinc.com.
cautions you that all statements, other than statements of historical facts, contained in this press release, are forward-looking
statements. Forward-looking statements, in some cases, can be identified by terms such as "believe," "may,"
"will," "estimate," "continue," "anticipate," "design," "intend,"
"expect," "could," "plan," "potential," "predict," "seek,"
"should," "would," "contemplate," project," "target," "tend to,"
or the negative version of these words and similar expressions. Such statements include, but are not limited to, statements relating
to the timing of when we propose a clinical plan to the U.S. Food and Drug Administration and the sharing of the outcome of those
discussions when they are available, and that MRI results are supportive evidence showing that OPC1 cells have durably engrafted
to help prevent cavitation at the injury site. Forward-looking statements involve known and unknown risks, uncertainties and other
factors that may cause BioTime's actual results, performance or achievements to be materially different from future results,
performance or achievements expressed or implied by the forward-looking statements in this press release, including, without limitation,
risk and uncertainties related to: BioTime's ability to raise additional capital when and as needed, to advance its product
candidates; BioTime's ability to develop and commercialize product candidates; the failure or delay in starting, conducting
and completing clinical trials or obtaining FDA or foreign regulatory approval for BioTime's product candidates in a timely
manner; the therapeutic potential of BioTime's product candidates, and the disease indications for which BioTime intends
to develop its product candidates; BioTime's ability to conduct and design successful clinical trials, to enroll a sufficient
number of patients, to meet established clinical endpoints, to avoid undesirable side effects and other safety concerns, and to
demonstrate sufficient efficacy of its product candidates; developments by BioTime competitors that make BioTime's product
candidates less competitive or obsolete; BioTime's ability to manufacture its product candidates for clinical development
and, if approved, for commercialization, and the timing and costs of such manufacture; the performance of third parties in connection
with the development and manufacture of BioTime's product candidates, including third parties conducting clinical trials
as well as third-party suppliers and manufacturers; the potential of BioTime's cell therapy platform, and BioTime's
plans to apply its platform to research, develop and commercialize our product candidates; BioTime's ability, and the ability
of its licensors, to obtain, maintain, defend and enforce intellectual property rights protecting BioTime's product candidates,
and BioTime's ability to develop and commercialize its product candidates without infringing the proprietary rights of third
parties; BioTime's ability to recruit and retain key personnel; and BioTime's ability to successfully integrate the
operations of Asterias into BioTime. BioTime's forward-looking statements are based upon its current expectations and involve
assumptions that may never materialize or may prove to be incorrect. All forward-looking statements are expressly qualified in
their entirety by these cautionary statements. For a detailed description of BioTime's risks and uncertainties, you are
encouraged to review its documents filed with the SEC including its recent filings on Form 8-K, Form 10-K and Form 10-Q. You are
cautioned not to place undue reliance on forward-looking statements, which speak only as of the date on which they were made.
BioTime undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the
date on which they were made, except as required by law.
Last updated: Apr 26, 2019