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Krystal Biotech to Announce Interim Clinical Update from Highest Dose Cohort of Phase 1 CORAL-1 Study Evaluating KB407 in Patients with Cystic Fibrosis

Key Takeaway: Krystal Biotech, Inc. announced it will hold an investor conference call on January 8, 2026, to provide an interim update from its Phase 1 CORAL-1 study evaluating KB407 for cystic fibrosis. The update will focus on molecular assessments related to KB407 transduction and CFTR protein expression in patients receiving the highest dose. This follows the company's ongoing commitment to develop genetic medicines for unmet medical needs.
Price reaction · baseline $249.39 (2026-01-06 close) · hit after-hours · 2 other KRYS headline(s) in the window, move may be shared
day 0 close · peak
-1.2%

Market Sentiment Analysis

POSITIVE FACTORS

  • Krystal Biotech is advancing its clinical program with KB407 targeting cystic fibrosis.
  • The upcoming interim update will provide key insights from the highest dose cohort.
  • The company has established itself with its first commercial product, VYJUVEK®.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Best trade, last catalyst
+100%
120-day peak, hindsight
Typical move
4.2%
average across 5 past catalysts
Lead asset
KB707
Phase 1 · Cancer

Full Press Release Details

PITTSBURGH, Jan. 07, 2026 (GLOBE NEWSWIRE) -- Krystal Biotech, Inc. (the “Company”) (NASDAQ: KRYS) today announced that it will host an investor conference call and webcast tomorrow, Thursday, January 8, 2026, at 4:30 pm ET, to disclose an interim clinical update from CORAL-1, the Company’s multi-center, dose escalation Phase 1 study evaluating KB407 in patients with cystic fibrosis. The interim clinical update will focus on results from patients in the highest dose cohort of CORAL-1 and include molecular assessments of KB407 transduction and wild-type cystic fibrosis transmembrane conductance regulator (CFTR) protein expression following inhaled administration of KB407.
Investors and the general public can access the live webcast at: https://www.webcaster5.com/Webcast/Page/3018/53466. For those unable to listen to the live webcast, an archived version will also be available on the Investors section of the Company’s website for at least 30 days.
About Krystal Biotech, Inc.
Krystal Biotech, Inc. (NASDAQ: KRYS) is a fully integrated, commercial-stage, global biotechnology company focused on the discovery, development and commercialization of genetic medicines to treat diseases with high unmet medical needs. VYJUVEK®, the Company’s first commercial product, is the first-ever redosable gene therapy and the first genetic medicine approved in the United States, Europe, and Japan for the treatment of dystrophic epidermolysis bullosa. The Company is rapidly advancing a robust preclinical and clinical pipeline of investigational genetic medicines in respiratory, oncology, dermatology, ophthalmology, and aesthetics. Krystal Biotech is headquartered in Pittsburgh, Pennsylvania. For more information, please visit http://www.krystalbio.com, and follow @KrystalBiotech on LinkedIn and X (formerly Twitter).
Investors and Media:

Frequently Asked Questions

When will Krystal Biotech host the investor conference call?

Krystal Biotech will host the investor conference call on January 8, 2026, at 4:30 pm ET.

What is the focus of the CORAL-1 study update?

The interim update will concentrate on results from the highest dose cohort of CORAL-1.

How can I access the live webcast of the conference?

The live webcast can be accessed at https://www.webcaster5.com/Webcast/Page/3018/53466.

What is VYJUVEK®?

VYJUVEK® is Krystal Biotech's first commercial product and a redosable gene therapy.

Where is Krystal Biotech located?

Krystal Biotech is headquartered in Pittsburgh, Pennsylvania.

Last updated: Jan 7, 2026