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Kalaris to Present Phase 1 Clinical Data for TH103 at the Macula Society Annual Meeting

Key Takeaway: Kalaris Therapeutics will present Phase 1 clinical data for TH103 at the Macula Society Annual Meeting from February 25-28, 2026. The therapy, engineered for enhanced VEGF inhibition, targets treatment-naive patients with neovascular age-related macular degeneration. Key details include safety and efficacy outcomes from the study, presented by Dr. Dean Eliott.
Price reaction · baseline $9.45 (2026-01-28 close) · hit after-hours · clean, no other KLRS news in the window
day 0 close · peak
-2.6%

Market Sentiment Analysis

POSITIVE FACTORS

  • Kalaris is presenting promising Phase 1 clinical data.
  • TH103 shows potential for enhanced VEGF inhibition.
  • The presentation will be attended by leading retinal specialists.
  • The Macula Society Annual Meeting is a prestigious event.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Cash runway
~24 mo
Low dilution risk
Lead asset
Posoleucel
Phase 2 · Adenovirus Infection

Full Press Release Details

BERKELEY HEIGHTS, N.J., Jan. 28, 2026 (GLOBE NEWSWIRE) -- Kalaris Therapeutics, Inc. (NASDAQ: KLRS) (“Kalaris”), a clinical-stage biopharmaceutical company developing differentiated therapies for retinal diseases, today announced that clinical data from its Phase 1 study of TH103 will be presented at the 49th Annual Meeting of the Macula Society, taking place February 25-28 in San Diego, California.
TH103 is a novel investigational therapy engineered by VEGF scientific pioneer Dr. Napoleone Ferrara to achieve enhanced VEGF inhibition and increased intraocular retention. The presentation will include safety, tolerability, pharmacokinetics and early efficacy outcomes following intravitreal administration of TH103 in patients with treatment-naive neovascular age-related macular degeneration. The data will be presented during a scientific session attended by leading retinal specialists and clinical investigators.
Presentation Details:
• Title: First-in-Human Evaluation of TH103, a Dual-Targeting VEGF and HSPG Inhibitor: Phase 1 Single Ascending Dose Study in Treatment-Naïve Neovascular AMD
• Speaker: Dean Eliott, MD, S.E. Gragoudas Professor of Ophthalmology, Harvard Medical School, Director Emeritus of Retina Service, Massachusetts Eye & Ear Infirmary
• Date: Thursday, February 26, 2026
• Time: 8:15 am PT
• Session: Neovascular AMD I: Clinical Trials
• Location: Southpointe Ballroom, Hotel Del Coronado, San Diego, CA
The Macula Society Annual Meeting is a highly selective, invitation-only forum where internationally recognized retinal experts convene to present and critically evaluate emerging clinical data and novel therapeutic strategies in retinal vascular and macular disease.
About Kalaris
Kalaris Therapeutics is a clinical-stage biopharmaceutical company dedicated to the development and commercialization of treatments for prevalent retinal diseases. Founded by renowned scientist Dr. Napoleone Ferrara, whose pioneering research led to the development of anti-VEGF therapy, the company is committed to advancing novel therapeutic approaches for patients with sight-threatening retinal conditions with major unmet medical needs.
For more information, visit www.kalaristx.com .

Frequently Asked Questions

What is TH103?

TH103 is a novel investigational therapy designed for enhanced VEGF inhibition.

When will Kalaris present the Phase 1 data?

The data will be presented on February 26, 2026.

Where is the Macula Society Annual Meeting held?

It will take place at the Hotel Del Coronado in San Diego, California.

Who is presenting the data?

Dr. Dean Eliott will present the data during the session.

What conditions does TH103 target?

TH103 targets treatment-naive neovascular age-related macular degeneration.

Last updated: Jan 28, 2026