Kairos Pharma Presents Preclinical Data on its Investigational Compounds KROS 101 and KROS 401 Further Supporting Both Compounds' Potential as Therapeutics for Melanoma and Glioblastoma

Pharma Presents Preclinical Data on its Investigational Compounds KROS 101 and KROS 401 Further Supporting Both Compounds' Potential

as Therapeutics for Melanoma and Glioblastoma

ANGELES - February 26, 2025 - Kairos Pharma, Ltd. (NYSE American: KAPA), a clinical-stage biopharmaceutical company,

announced that the company presented preclinical data on its investigational compounds KROS 101 and KROS 401 during the American Association

for Cancer Research Immuno-Oncology (AACR IO) conference held in Los Angeles from February 23-26, 2025. The data highlighted positive

preclinical outcomes with the Company's glucocorticoid-induced tumor necrosis factor receptor (GITR) agonist KROS101 in melanoma

and glioblastoma as well as its peptide inhibitor for macrophages KROS 401 in glioma animal models.

the presentation, titled "KROS 101: A Next Generation GITR agonist boosting anti-tumor T cell responses and reprogramming

the tumor environment," study authors demonstrated that KROS significantly inhibited tumor growth in a preclinical melanoma model.

The same team of scientists also showed that KROS 101 increased the proliferation of helper and cytotoxic T cells (CD4+ and CD8+), while

decreasing T reg cell growth in a melanoma model. Further, T cells treated with KROS 101 showed cytotoxicity against glioblastoma cell

lines and glioma cancer cells, which study authors, Admasu, et. al., concluded KROS 101 demonstrated potent anti-tumor activity compared

to a previously used antibody against the GITR receptor TRX518 that was in clinical trials. Most importantly, the authors demonstrated

KROS 101 but not TRX518 to prevent the exhaustion of T cells in the tumor.

second presentation, titled "Targeting M2 macrophage polarization: The anti-tumor effects of IL-4/IL-13 blocking peptide and iron

oxide nanoparticles," demonstrated the Company's peptide inhibitor KROS 401 may effectively reprogram macrophages -

types of white blood cell of the innate immune system that engulf and digest pathogens, such as cancer cells, microbes, cellular debris

and foreign substances - to inhibit tumor growth. The preclinical study demonstrated that KROS 401 exhibited an anti-tumor effect

in glioma-bearing mice following a decrease in M2 macrophages, which are known to facilitate tumor growth.

John Yu, CEO of Kairos Pharma and co-inventor, commented, "We continue to receive validation of our preclinical data demonstrating

our KROS platform's development of anti-tumor therapies. KROS 101 addresses an Achille's heel of all T cell immunotherapies

and that is the development of exhaustion in anti-tumor T cells. KROS 101 appears to prevent the development of exhaustion by T cells

enabling them to continue to kill tumor cells."

Ram Murali, VP of Research and Development stated, "KROS 401 is designed to reverse the M1 to M2 transition of macrophages in the

tumor microenviroment. What this translates to is changing pro-tumor macrophages into anti-tumor macrophages. This leads to tumor-killing

activity by both macrophages and T cells."

American Association for Cancer Research Immuno-Oncology (AACR IO) encompasses the very best of basic, translational, and clinical research

in immunology, inflammation, and immunotherapies for cancer, including immuno-oncology (IO) drugs, inflammatory modulators, vaccines,

and cellular therapies. The cutting-edge AACR IO 2025 program will appeal to a wide audience of basic scientists, translational researchers,

clinical investigators, regulators, industry, investors, and lay press. A mix of keynote lectures, major symposia, spotlight sessions,

educational sessions, special sessions, and poster sessions with exhibits will cover the spectrum of the IO field-including late-breaking

clinical trials sessions highlighting new agents and IO combinations, and the results of practice-changing clinical trials.

in Los Angeles, California, Kairos Pharma Ltd. (NYSE American: KAPA) is at the forefront of oncology therapeutics, utilizing structural

biology to overcome drug resistance and immune suppression in cancer. Our lead candidate, ENV105, is an antibody that targets CD105 -

a protein identified as a key driver of resistance to various cancer treatments. Elevation of CD105 in response to standard therapy results

in resistance and disease relapse. ENV105 aims to reverse drug resistance by targeting CD105 and restore the effectiveness of standard

therapies across multiple cancer types. Currently, ENV105 is in a Phase 2 clinical trial for castrate-resistant prostate cancer and a

Phase 1 trial for lung cancer aimed at addressing significant unmet medical needs. For more information, visit kairospharma.com.

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