Kairos Pharma Ltd. Announces Peer Reviewed Publication Highlighting Potentially Groundbreaking Discovery in Overcoming Drug Resistance in Non-Small Cell Lung Cancer

Pharma Ltd. Announces Peer Reviewed Publication Highlighting Potentially Groundbreaking Discovery in Overcoming Drug Resistance in Non-Small

ANGELES - March 20, 2025 - Kairos Pharma, Ltd. (NYSE American: KAPA), a clinical-stage biopharmaceutical company, announces

a peer-reviewed publication highlighting a potentially significant breakthrough in addressing drug resistance to EGFR-targeted therapies

for non-small cell lung cancer (NSCLC) patients. Recent findings published in Drug Resistance Updates highlight the critical role

of CD105 (endoglin) in mediating resistance to osimertinib, a frontline treatment for EGFR-mutant NSCLC. The study, entitled "CD105

blockade restores osimertinib sensitivity in drug-resistant EGFR-mutant non-small cell lung cancer" demonstrated that CD105 expression

is upregulated as a mechanism of therapy resistance, correlating with poor prognosis in patients.

believe our latest findings represent a paradigm shift in overcoming resistance to EGFR-targeted therapies in NSCLC," said Neil

Bhowmick, Ph.D., Kairos Pharm Chief Scientific Officer. "Revealing this mechanism-of-action underscores our commitment to advancing

precision oncology and bringing innovative therapies to patients in need."

preclinical models, targeting CD105 with ENV105 (carotuximab), a CD105-neutralizing antibody successfully restored treatment sensitivity

to EGFR-targeted therapies. Notably, combining osimertinib with ENV105 reinstated susceptibility to EGFR inhibition through metabolic

reprogramming and enhanced chromatin accessibility. These findings confirm the efficacy of this novel combination therapy strategy in

overcoming drug resistance in this model of non-small cell lung cancer.

John Yu, CEO stated, "These findings in lung cancer corroborate data in prostate cancer, breast cancer and colon cancer, that point

to CD105 being a central mechanism of cancer drug resistance." We believe ENV105 can reverse this resistance in cancer models,

and our clinical trials are designed to definitively demonstrate its potential impact."

global NSCLC treatment market is projected to reach $45 billion by 2030, driven by advancements in targeted therapies. However, drug

resistance remains a major challenge. The ability of ENV105 to enhance EGFR-targeted therapy effectiveness positions it as a high-value

asset in next-generation oncology treatment. Kairos Pharma is currently evaluating this transformative cancer therapy in ongoing clinical

trials for EGFR-driven lung cancer patients. The study can be accessed here.

in Los Angeles, California, Kairos Pharma Ltd. (NYSE American: KAPA) is at the forefront of oncology therapeutics, utilizing structural

biology to overcome drug resistance and immune suppression in cancer. Our lead candidate, ENV105, is an antibody that targets CD105 -

a protein identified as a key driver of resistance to various cancer treatments. Elevation of CD105 in response to standard therapy results

in resistance and disease relapse. ENV105 aims to reverse drug resistance by targeting CD105 and restore the effectiveness of standard

therapies across multiple cancer types. Currently, ENV105 is in a Phase 2 clinical trial for castrate-resistant prostate cancer and a

Phase 1 trial for lung cancer aimed at addressing significant unmet medical needs. For more information, visit kairospharma.com.

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of our Phase 1 and Phase 2 clinical trials; our success in completing newly initiated clinical trials, commence new trials, and obtain

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