Andrew Markwick, QuintilesIMS Investor Relations ( andrew.markwick@quintilesims.com ) +1.973.257.7144 Tor Constantino, QuintilesIMS Media Relations ( tor.constantino@quintilesims.com ) +1.484.567.6

QuintilesIMS Announces Pricing on Upsizing Offering of Senior Notes

DANBURY, Conn. & RESEARCH TRIANGLE PARK, N.C. February 23, 2017 Quintiles IMS Holdings, Inc. ( QuintilesIMS ) (NYSE: Q)

today announced the pricing of the offering of 1.425 billion in gross proceeds of senior notes to be issued by its wholly owned subsidiary, Quintiles IMS Incorporated (the Issuer ). The offering was upsized from the previously

announced 850 million aggregate principal amount. As a result of the upsize, while the Issuer still intends to refinance all of the outstanding term B loans under its senior secured credit facility with an extended and repriced term B loan

facility as previously announced, it has elected to no longer upsize the term B loan facility. The net proceeds from the notes offering, together with proceeds from the previously announced proposed refinancing, will be used to refinance certain of

the Issuer s existing indebtedness, to pay fees and expenses related to the notes offering and the refinancing and for other general corporate purposes, which may include share repurchases, including the repurchase of shares from affiliates and

significant shareholders, and future acquisitions.

The notes will bear interest at a rate of 3.25% and will pay interest semi-annually in arrears on

March 15th and September 15th of each year beginning on September 15, 2017. The notes will mature on March 15, 2025. The issuance of

the senior notes is expected to occur on or about February 28, 2017, subject to customary closing conditions.

Certain statements in this press

release are forward-looking statements. These statements involve a number of risks, uncertainties and other factors including the failure to consummate the notes offering and the refinancing and potential changes in market conditions that could

cause actual results to differ materially.

This press release does not constitute an offer to sell or the solicitation of an offer to buy the notes. The

notes have not been, and will not be, registered under the Securities Act of 1933 and may not be offered or sold in the United States absent registration or an applicable exemption from the registration requirements of the Securities Act of 1933.

The notes are being offered only to qualified institutional buyers in the United States in reliance on Rule 144A under the Securities Act of 1933 and outside the United States only to non-U.S. investors

pursuant to Regulation S.

QuintilesIMS (NYSE: Q) is a leading integrated information and technology-enabled healthcare service provider worldwide, dedicated to helping its clients

improve their clinical, scientific and commercial results. Formed through the merger of Quintiles Transnational and IMS Health, QuintilesIMS s approximately 50,000 employees conduct operations in more than 100 countries. Companies seeking to

improve real-world patient outcomes through treatment innovations, care provision and access can leverage QuintilesIMS s broad range of healthcare information, technology

and service solutions to drive new insights and approaches. QuintilesIMS provides solutions that span clinical to commercial, bringing customers a unique opportunity to realize the full potential

of innovations and advanced healthcare outcomes.

As a global leader in protecting individual patient privacy, QuintilesIMS uses healthcare data to

deliver critical, real-world disease and treatment insights. Through a wide variety of privacy-enhancing technologies and safeguards, QuintilesIMS protects individual privacy while managing information to drive healthcare forward. These insights and

execution capabilities help biotech, medical device and pharmaceutical companies, medical researchers, government agencies, payers and other healthcare stakeholders in the development and approval of new therapies, and to identify unmet treatment

needs and understand the safety, effectiveness and value of pharmaceutical products in improving overall health outcomes.